1. [Metalloproteinases. Structure and function].
- Author
-
Lipka D and Boratyński J
- Subjects
- 4-Aminobenzoic Acid metabolism, Animals, Apoptosis physiology, Arthritis drug therapy, Arthritis enzymology, Autoimmune Diseases enzymology, Cell Movement physiology, Chloroquine metabolism, Drug Combinations, Enzyme Activation, Extracellular Matrix metabolism, Humans, Matrix Metalloproteinase Inhibitors, Matrix Metalloproteinases classification, Membrane Proteins metabolism, Models, Molecular, Neoplasms drug therapy, Neoplasms enzymology, Neovascularization, Physiologic physiology, Pantothenic Acid metabolism, Pyridoxine metabolism, Quinacrine metabolism, Tissue Inhibitor of Metalloproteinases chemistry, Tissue Inhibitor of Metalloproteinases metabolism, Matrix Metalloproteinases chemistry, Matrix Metalloproteinases metabolism
- Abstract
Matrix metalloproteinases (MMPs) belong to a large family of multidomain zinc endopeptidases. They are one of the most important proteolitic enzymes which digest components of the extracellular matrix and abundant macromolecules on cell surface and take part in many physiological processes, such as apoptosis or angiogenesis. MMPs are also engaged in the pathogenesis of many diseases such as arthritis and cancer. The development of effective inhibitors and discovery of their mechanisms of action can have significant influence on therapeutic strategy.
- Published
- 2008