1. Comparison of CD163+ Macrophages and CD206+ Cells in Lesional Skin of CD30+ Lymphoproliferative Disorders of Lymphomatoid Papulosis and Primary Cutaneous Anaplastic Large-cell Lymphoma
- Author
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Aya Kakizaki, Kouetsu Ogasawara, Setsuya Aiba, Taku Fujimura, Sadanori Furudate, Mitsuko Kawano, and Yumi Kambayashi
- Subjects
Male ,Pathology ,medicine.medical_specialty ,CD30 ,Antigens, Differentiation, Myelomonocytic ,Ki-1 Antigen ,Lymphoproliferative disorders ,Receptors, Cell Surface ,Primary cutaneous anaplastic large cell lymphoma ,Dermatology ,Sensitivity and Specificity ,Sampling Studies ,Japan ,Lymphomatoid Papulosis ,Antigens, CD ,medicine ,Humans ,Lectins, C-Type ,Lymphomatoid papulosis ,Survival rate ,Tissue Embedding ,business.industry ,Macrophages ,Large cell ,Dendritic Cells ,General Medicine ,Prognosis ,medicine.disease ,Lymphoma ,Survival Rate ,Mannose-Binding Lectins ,Lymphoma, Large-Cell, Anaplastic ,Female ,business ,CD163 ,Biomarkers ,Mannose Receptor - Abstract
CD30+ lymphoproliferative disorders represent a spectrum of diseases from lymphomatoid papulosis (LyP) to primary cutaneous anaplastic large-cell lymphoma (PCALCL) (1, 2). LyP is characterized by recurrent papulonodular lesions, which undergo spontaneous regression (1, 2). Survival is unaffected by LyP, but patients are at risk of a second cutaneous or lymphoid malignancy (1). PCALCL has a favourable prognosis with a 5-year survival rate between 76% and 96%. In this report, we used immunohistochemical (IHC) staining of LyP type A and PCALCL specimens to examine for macrophage markers as well as dendritic cell (DC)-specific markers and their functional markers.
- Published
- 2015
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