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Aim: Rheumatic diseases cause economic burden due to apparently costs along with indirect costs including productivity loss. This study aims to assess work productivity in axial spondyloarthritis (SpA), rheumatoid arthritis (RA), and psoriatic arthritis (PsA), and determine its relation with fatigue, disease activity, depression, and quality of life. Material and Method: This cross-sectional study included 42 SpA, 36 PsA, 34 RA patients, and 30 controls. The number of swollen and tender joints, erythrocyte sedimentation rate, and C-reactive protein were recorded. Disease activity was determined by the Bath Ankylosing Spondylitis Disease Activity Index for SpA, Disease Activity in Psoriatic Arthritis for PsA, and Disease Activity Score-28 for RA. The Stanford Health Assessment Questionnaire, Short Form-36, Fatigue Symptom Inventory, and Beck Depression Inventory were performed. Pain was measured using the Visual Analog Scale. The Work Productivity and Activity Impairment scale was administered for work productivity. Logistic regression analysis was used to determine factors affecting work productivity. Correlations were assessed by Spearman’s correlation coefficient. Results: The rate of employment was 83.3% in SpA, 52.8% in PsA, 61.8% in RA, and 93.3% in controls. The percentage of absenteeism was higher in SpA and PsA. Percentage of presenteeism, percent total work impairment caused by health problems, and percent activity impairment due to health problems were higher in SpA, PsA, and RA patients than controls (p