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OBJECTIVE To improve the algorithm of differential diagnosis and complex treatment of patients with CR. MATERIAL AND METHODS Forty-two patients with CR were divided into 2 groups. Patients of the first group (n=21) received basic treatment (NSAID, myorelaxants, local injections with glucocorticoids (on demand), B vitamins and non-pharmacological methods) and the anticholinesterase drug ipidacrine. The second group (n=21) had only basic treatment. The total duration of the study was 45 days. The effectiveness of treatment was evaluated with VAS, NDI, GROC and total duration of disability period. RESULTS A battery of tests for the diagnosis of CR that included Spurling test, motor strength deficiency, ULTT, pain pattern, shoulder adduction test (diagnostic complex SPASIBO), has been developed. A positive result of all 5 tests guarantees the 94.7% accuracy of CR diagnosis. The application of ipidacrine has allowed a significant (p

Non-steroidal anti-inflammatory drugs (NSAIDs) are widely used for treatment of pain, fever and inflammatory diseases. However, along with a high rate of efficacy, NSAIDs have been associated with an increased risk of gastrointestinal and cardiovascular complications related to the inhibition of the enzymes cyclooxygenase 1 and 2. The review addresses contemporary mechanisms of NSAID's side-effects and analyzes clinical trials of the efficacy and tolerability of aceclofenac, which is the most frequently prescribed NSAID, as in its traditional release form (100 mg 2 times a day) as well as in the controlled-release (200 mg a day) form.Нестероидные противовоспалительные средства (НПВС) широко используются во всем мире в лечении боли, гипертермии и воспаления. Однако наряду с высокой эффективностью применение НПВС ассоциировано с увеличением рисков гастроинтестинальных и кардиоваскулярных побочных эффектов в несколько раз, что связано с ингибированием активности циклооксигеназы 1-го и 2-го типа. В обзоре рассматриваются современные механизмы развития побочных эффектов на фоне приема НПВС, анализируются данные клинических исследований, в которых изучали эффективность и переносимость одного из наиболее распространенных препаратов из данной группы - ацеклофенака, используемого как в традиционной форме выпуска (100 мг 2 раза в день), так и в форме с контролируемым высвобождением действующего вещества (200 мг 1 раз в день).