1. [An immunohistochemical study using monoclonal antibodies of the antigen of fat globule membranes in human milk].
- Author
-
Iakubovskaia RI, Baryshnikov AB, Karmakova TA, Kazachkina NI, Avdeev GI, Delektorskaia VV, Korotkova OV, Kadagidze ZG, Ermilova VD, and Zhordaniia KI
- Subjects
- Adult, Animals, Antibody Specificity immunology, Antigens, Surface analysis, Diagnosis, Differential, Embryo, Mammalian immunology, Female, Humans, Hybridomas immunology, Immunohistochemistry, Mice, Mucin-1, Neoplasms diagnosis, Antibodies, Monoclonal isolation & purification, Antigens, Neoplasm analysis, Membrane Glycoproteins analysis, Milk, Human immunology
- Abstract
Monoclonal antibodies (Mab) IKO-21 and IKO-25 obtained to the membrane antigen of the woman milk lipid globules were tested immuno- and cytochemically on the samples of human normal definitive and embryonal tissues and tumours. Mab IKO-21 are shown to react, apart from epithelial tissues, with a vascular endothelium and blood cells. Mab IKO-25 are specific to the epithelial tissue and malignant epithelial tumours. Their intensive reaction with the cells of malignant tumours of the mammary gland, lung, ovary and the type of their distribution in the organs and tissues enables their use in the differential diagnosis of malignant epithelial and non-epithelial tumours as for revealing metastases both in vitro and in vivo.
- Published
- 1991