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In this article describe the clinical case of treatment of melanoma of the larynx mucous membrane.Presented the clinic, immunohistochemistrydiagnostics and methods of surgical treatment.

The article presents an original technique of voice restoration in patients who have undergone laryngopharyngectomy with resection of esophageal cervical part; analyses mechanism of phonation. Four cases of prosthetic reconstruction are reported. The necessity and feasibility of voice rehabilitation in patients with this severe condition are validated.

The expression of gene K51 in the cells of human normal epidermis and epithelial skin tumors was investigated using in situ hybridization method with radioactive probe. The K51 gene transcripts were detected in the epidermis, sebaceous and sweat glands of human embryo and adult skin. The level of gene expression was higher in the stratum granulosum than in the basal layer of the skin. K51 gene expression was also found in the basal cell and metatypical carcinomas, with the level of expression lower than in the neighbouring epidermis and higher than in the surrounding skin stromal cells. Thus, K51 gene is expressed in the skin epidermis of human embryo and adults but the level of its activity is dramatically decreased in the cells of skin epithelial tumors. This potentially may be important as a diagnostic test.