1. [Pharmacological prevention of cerebrovascular complications in cardiac patients after coronary artery bypass surgery].
- Author
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Efimova NIu, Chernov VI, Efimova IIu, Akhmedov ShD, Podoksenov IuK, and Lishmanov IuB
- Subjects
- Cerebrovascular Circulation drug effects, Cerebrovascular Circulation physiology, Cognition Disorders etiology, Cognition Disorders physiopathology, Drug Combinations, Female, Humans, Male, Middle Aged, Myocardial Ischemia complications, Benzamides therapeutic use, Cognition Disorders prevention & control, Coronary Artery Bypass adverse effects, Hexobendine therapeutic use, Myocardial Ischemia surgery, Theophylline analogs & derivatives, Theophylline therapeutic use
- Abstract
The aim of the study was to evaluate cognitive functions and cerebral perfusion in cardiac patients following coronary artery bypass graft surgery (CABG) and to investigate a potential of pharmacological prevention of neurocognitive deficit and cerebral perfusion disorders. Forty patients undergone CABG with cardiopulmonary bypass (CPB) were included in the study. For prevention of cerebral perfusion impairments and cognitive deficit, instenon ("Nycomed") was administered to 18 of the patients. The results revealed that the use of instenon allowed reducing a negative effect of CABG with CPB on neuropsychological state of the patients, thus preventing cerebral perfusion disturbances during surgery intervention.
- Published
- 2003