1. [Means for the inhibition of the nonimmune progression of nephritis].
- Author
-
Tareeva IE, Kutyrina IM, and Neverov NI
- Subjects
- Angiotensin-Converting Enzyme Inhibitors therapeutic use, Blood Pressure drug effects, Calcium Channel Blockers therapeutic use, Chronic Disease, Combined Modality Therapy, Disease Progression, Drug Therapy, Combination, Glomerulonephritis diet therapy, Glomerulonephritis drug therapy, Humans, Hypolipidemic Agents therapeutic use, Nephritis diet therapy, Proteinuria diet therapy, Proteinuria drug therapy, Nephritis drug therapy
- Abstract
Inhibition of non-immune progression of renal insufficiency for control of glomerulonephritis was attempted via hemodynamic, metabolic and hypolipidemic means. Hemodynamic correction was conducted using inhibitors of angiotensin-converting enzyme capoten and renitek. The action on metabolic factors of progression was realized by lovastatin mevakor. Capoten and renitek exhibited in 57 patients with chronic nephritis not only a hypotensive effect, but also reduced intraglomerular hypertension and proteinuria. A long-term (7-12 months) hypolipidemic therapy (diet and lovastatin) in 20 patients with chronic glomerulonephritis with nephrotic syndrome resulted in lowering of serum cholesterol concentrations and proteinuria, raised serum albumin. 9 patients achieved remission of nephrotic syndrome. The highest effect occurred in non-inflammatory nephropathy: membranous nephropathy, focal-segmental glomerulosclerosis, nephrosclerosis.
- Published
- 1995