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Your search keyword '"Grigore, Liliana"' showing total 16 results
Start Over Author "Grigore, Liliana" Publisher med univ innsbruck, dept neurol, innsbruck, austria.
16 results on '"Grigore, Liliana"'

1. Association of Intima-Media Thickness Measured at the Common Carotid Artery With Incident Carotid Plaque : Individual Participant Data Meta-Analysis of 20 Prospective Studies

Author

Tschiderer, Lena, Seekircher, Lisa, Izzo, Raffaele, Mancusi, Costantino V., Manzi, Maria, Baldassarre, Damiano, Amato, Mauro, Tremoli, Elena, Veglia, Fabrizio, Tuomainen, Tomi-Pekka, Kauhanen, Jussi, Voutilainen, Ari, Iglseder, Bernhard, Lind, Lars, Rundek, Tatjana, Desvarieux, Moise, Kato, Akihiko, de Groot, Eric, Asci, Guelay, Ok, Ercan, Agewall, Stefan, Beulens, Joline W. J. D., Byrne, Christopher C., Calder, Philip C., Gerstein, Hertzel, Gresele, Paolo, Klingenschmid, Gerhard, Nagai, Michiaki H., Olsen, Michael, Parraga, Grace S., Safarova, Maya, Sattar, Naveed, Skilton, Michael, Stehouwer, Coen D. A., Uthoff, Heiko A., van Agtmael, Michiel A., van der Heijden, Amber A., Zozulinska-Ziolkiewicz, Dorota, Park, Hyun-Woong, Lee, Moo-Sik, Bae, Jang-Ho, Beloqui, Oscar F., Landecho, Manuel, Plichart, Matthieu, Ducimetiere, Pierre, Empana, Jean Philippe, Bokemark, Lena, Bergstroem, Goeran, Schmidt, Caroline, Castelnuovo, Samuela, Calabresi, Laura D., Norata, Giuseppe, Grigore, Liliana, Catapano, Alberico, Zhao, Dong, Wang, Miao, Liu, Jing, Ikram, M. Arfan, Kavousi, Maryam L., Bots, Michiel J., Sweeting, Michael W., Lorenz, Matthias, Willeit, Peter, Tschiderer, Lena, Seekircher, Lisa, Izzo, Raffaele, Mancusi, Costantino V., Manzi, Maria, Baldassarre, Damiano, Amato, Mauro, Tremoli, Elena, Veglia, Fabrizio, Tuomainen, Tomi-Pekka, Kauhanen, Jussi, Voutilainen, Ari, Iglseder, Bernhard, Lind, Lars, Rundek, Tatjana, Desvarieux, Moise, Kato, Akihiko, de Groot, Eric, Asci, Guelay, Ok, Ercan, Agewall, Stefan, Beulens, Joline W. J. D., Byrne, Christopher C., Calder, Philip C., Gerstein, Hertzel, Gresele, Paolo, Klingenschmid, Gerhard, Nagai, Michiaki H., Olsen, Michael, Parraga, Grace S., Safarova, Maya, Sattar, Naveed, Skilton, Michael, Stehouwer, Coen D. A., Uthoff, Heiko A., van Agtmael, Michiel A., van der Heijden, Amber A., Zozulinska-Ziolkiewicz, Dorota, Park, Hyun-Woong, Lee, Moo-Sik, Bae, Jang-Ho, Beloqui, Oscar F., Landecho, Manuel, Plichart, Matthieu, Ducimetiere, Pierre, Empana, Jean Philippe, Bokemark, Lena, Bergstroem, Goeran, Schmidt, Caroline, Castelnuovo, Samuela, Calabresi, Laura D., Norata, Giuseppe, Grigore, Liliana, Catapano, Alberico, Zhao, Dong, Wang, Miao, Liu, Jing, Ikram, M. Arfan, Kavousi, Maryam L., Bots, Michiel J., Sweeting, Michael W., Lorenz, Matthias, and Willeit, Peter

Abstract

Background: The association between common carotid artery intima-media thickness (CCA-IMT) and incident carotid plaque has not been characterized fully. We therefore aimed to precisely quantify the relationship between CCA-IMT and carotid plaque development. Methods and Results: We undertook an individual participant data meta-analysis of 20 prospective studies from the Proof-ATHERO (Prospective Studies of Atherosclerosis) consortium that recorded baseline CCA-IMT and incident carotid plaque involving 21 494 individuals without a history of cardiovascular disease and without preexisting carotid plaque at baseline. Mean baseline age was 56 years (SD, 9 years), 55% were women, and mean baseline CCA-IMT was 0.71 mm (SD, 0.17 mm). Over a median follow-up of 5.9 years (5th-95th percentile, 1.9-19.0 years), 8278 individuals developed first-ever carotid plaque. We combined study-specific odds ratios (ORs) for incident carotid plaque using random-effects meta-analysis. Baseline CCA-IMT was approximately log-linearly associated with the odds of developing carotid plaque. The age-, sex-, and trial arm-adjusted OR for carotid plaque per SD higher baseline CCA-IMT was 1.40 (95% CI, 1.31-1.50; I-2=63.9%). The corresponding OR that was further adjusted for ethnicity, smoking, diabetes, body mass index, systolic blood pressure, low- and high-density lipoprotein cholesterol, and lipid-lowering and antihypertensive medication was 1.34 (95% CI, 1.24-1.45; I-2=59.4%; 14 studies; 16 297 participants; 6381 incident plaques). We observed no significant effect modification across clinically relevant subgroups. Sensitivity analysis restricted to studies defining plaque as focal thickening yielded a comparable OR (1.38 [95% CI, 1.29-1.47]; I-2=57.1%; 14 studies; 17 352 participants; 6991 incident plaques). Conclusions: Our large-scale individual participant data meta-analysis demonstrated that CCA-IMT is associated with the long-term risk of developing first-ever carotid plaque, independent

Published
2023
Full Text
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2. Association of Intima-Media Thickness Measured at the Common Carotid Artery With Incident Carotid Plaque : Individual Participant Data Meta-Analysis of 20 Prospective Studies

Author

Tschiderer, Lena, Seekircher, Lisa, Izzo, Raffaele, Mancusi, Costantino V., Manzi, Maria, Baldassarre, Damiano, Amato, Mauro, Tremoli, Elena, Veglia, Fabrizio, Tuomainen, Tomi-Pekka, Kauhanen, Jussi, Voutilainen, Ari, Iglseder, Bernhard, Lind, Lars, Rundek, Tatjana, Desvarieux, Moise, Kato, Akihiko, de Groot, Eric, Asci, Guelay, Ok, Ercan, Agewall, Stefan, Beulens, Joline W. J. D., Byrne, Christopher C., Calder, Philip C., Gerstein, Hertzel, Gresele, Paolo, Klingenschmid, Gerhard, Nagai, Michiaki H., Olsen, Michael, Parraga, Grace S., Safarova, Maya, Sattar, Naveed, Skilton, Michael, Stehouwer, Coen D. A., Uthoff, Heiko A., van Agtmael, Michiel A., van der Heijden, Amber A., Zozulinska-Ziolkiewicz, Dorota, Park, Hyun-Woong, Lee, Moo-Sik, Bae, Jang-Ho, Beloqui, Oscar F., Landecho, Manuel, Plichart, Matthieu, Ducimetiere, Pierre, Empana, Jean Philippe, Bokemark, Lena, Bergstroem, Goeran, Schmidt, Caroline, Castelnuovo, Samuela, Calabresi, Laura D., Norata, Giuseppe, Grigore, Liliana, Catapano, Alberico, Zhao, Dong, Wang, Miao, Liu, Jing, Ikram, M. Arfan, Kavousi, Maryam L., Bots, Michiel J., Sweeting, Michael W., Lorenz, Matthias, Willeit, Peter, Tschiderer, Lena, Seekircher, Lisa, Izzo, Raffaele, Mancusi, Costantino V., Manzi, Maria, Baldassarre, Damiano, Amato, Mauro, Tremoli, Elena, Veglia, Fabrizio, Tuomainen, Tomi-Pekka, Kauhanen, Jussi, Voutilainen, Ari, Iglseder, Bernhard, Lind, Lars, Rundek, Tatjana, Desvarieux, Moise, Kato, Akihiko, de Groot, Eric, Asci, Guelay, Ok, Ercan, Agewall, Stefan, Beulens, Joline W. J. D., Byrne, Christopher C., Calder, Philip C., Gerstein, Hertzel, Gresele, Paolo, Klingenschmid, Gerhard, Nagai, Michiaki H., Olsen, Michael, Parraga, Grace S., Safarova, Maya, Sattar, Naveed, Skilton, Michael, Stehouwer, Coen D. A., Uthoff, Heiko A., van Agtmael, Michiel A., van der Heijden, Amber A., Zozulinska-Ziolkiewicz, Dorota, Park, Hyun-Woong, Lee, Moo-Sik, Bae, Jang-Ho, Beloqui, Oscar F., Landecho, Manuel, Plichart, Matthieu, Ducimetiere, Pierre, Empana, Jean Philippe, Bokemark, Lena, Bergstroem, Goeran, Schmidt, Caroline, Castelnuovo, Samuela, Calabresi, Laura D., Norata, Giuseppe, Grigore, Liliana, Catapano, Alberico, Zhao, Dong, Wang, Miao, Liu, Jing, Ikram, M. Arfan, Kavousi, Maryam L., Bots, Michiel J., Sweeting, Michael W., Lorenz, Matthias, and Willeit, Peter

Abstract

Background: The association between common carotid artery intima-media thickness (CCA-IMT) and incident carotid plaque has not been characterized fully. We therefore aimed to precisely quantify the relationship between CCA-IMT and carotid plaque development. Methods and Results: We undertook an individual participant data meta-analysis of 20 prospective studies from the Proof-ATHERO (Prospective Studies of Atherosclerosis) consortium that recorded baseline CCA-IMT and incident carotid plaque involving 21 494 individuals without a history of cardiovascular disease and without preexisting carotid plaque at baseline. Mean baseline age was 56 years (SD, 9 years), 55% were women, and mean baseline CCA-IMT was 0.71 mm (SD, 0.17 mm). Over a median follow-up of 5.9 years (5th-95th percentile, 1.9-19.0 years), 8278 individuals developed first-ever carotid plaque. We combined study-specific odds ratios (ORs) for incident carotid plaque using random-effects meta-analysis. Baseline CCA-IMT was approximately log-linearly associated with the odds of developing carotid plaque. The age-, sex-, and trial arm-adjusted OR for carotid plaque per SD higher baseline CCA-IMT was 1.40 (95% CI, 1.31-1.50; I-2=63.9%). The corresponding OR that was further adjusted for ethnicity, smoking, diabetes, body mass index, systolic blood pressure, low- and high-density lipoprotein cholesterol, and lipid-lowering and antihypertensive medication was 1.34 (95% CI, 1.24-1.45; I-2=59.4%; 14 studies; 16 297 participants; 6381 incident plaques). We observed no significant effect modification across clinically relevant subgroups. Sensitivity analysis restricted to studies defining plaque as focal thickening yielded a comparable OR (1.38 [95% CI, 1.29-1.47]; I-2=57.1%; 14 studies; 17 352 participants; 6991 incident plaques). Conclusions: Our large-scale individual participant data meta-analysis demonstrated that CCA-IMT is associated with the long-term risk of developing first-ever carotid plaque, independent

Published
2023
Full Text
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3. Association of Intima-Media Thickness Measured at the Common Carotid Artery With Incident Carotid Plaque : Individual Participant Data Meta-Analysis of 20 Prospective Studies

Author

Tschiderer, Lena, Seekircher, Lisa, Izzo, Raffaele, Mancusi, Costantino V., Manzi, Maria, Baldassarre, Damiano, Amato, Mauro, Tremoli, Elena, Veglia, Fabrizio, Tuomainen, Tomi-Pekka, Kauhanen, Jussi, Voutilainen, Ari, Iglseder, Bernhard, Lind, Lars, Rundek, Tatjana, Desvarieux, Moise, Kato, Akihiko, de Groot, Eric, Asci, Guelay, Ok, Ercan, Agewall, Stefan, Beulens, Joline W. J. D., Byrne, Christopher C., Calder, Philip C., Gerstein, Hertzel, Gresele, Paolo, Klingenschmid, Gerhard, Nagai, Michiaki H., Olsen, Michael, Parraga, Grace S., Safarova, Maya, Sattar, Naveed, Skilton, Michael, Stehouwer, Coen D. A., Uthoff, Heiko A., van Agtmael, Michiel A., van der Heijden, Amber A., Zozulinska-Ziolkiewicz, Dorota, Park, Hyun-Woong, Lee, Moo-Sik, Bae, Jang-Ho, Beloqui, Oscar F., Landecho, Manuel, Plichart, Matthieu, Ducimetiere, Pierre, Empana, Jean Philippe, Bokemark, Lena, Bergstroem, Goeran, Schmidt, Caroline, Castelnuovo, Samuela, Calabresi, Laura D., Norata, Giuseppe, Grigore, Liliana, Catapano, Alberico, Zhao, Dong, Wang, Miao, Liu, Jing, Ikram, M. Arfan, Kavousi, Maryam L., Bots, Michiel J., Sweeting, Michael W., Lorenz, Matthias, Willeit, Peter, Tschiderer, Lena, Seekircher, Lisa, Izzo, Raffaele, Mancusi, Costantino V., Manzi, Maria, Baldassarre, Damiano, Amato, Mauro, Tremoli, Elena, Veglia, Fabrizio, Tuomainen, Tomi-Pekka, Kauhanen, Jussi, Voutilainen, Ari, Iglseder, Bernhard, Lind, Lars, Rundek, Tatjana, Desvarieux, Moise, Kato, Akihiko, de Groot, Eric, Asci, Guelay, Ok, Ercan, Agewall, Stefan, Beulens, Joline W. J. D., Byrne, Christopher C., Calder, Philip C., Gerstein, Hertzel, Gresele, Paolo, Klingenschmid, Gerhard, Nagai, Michiaki H., Olsen, Michael, Parraga, Grace S., Safarova, Maya, Sattar, Naveed, Skilton, Michael, Stehouwer, Coen D. A., Uthoff, Heiko A., van Agtmael, Michiel A., van der Heijden, Amber A., Zozulinska-Ziolkiewicz, Dorota, Park, Hyun-Woong, Lee, Moo-Sik, Bae, Jang-Ho, Beloqui, Oscar F., Landecho, Manuel, Plichart, Matthieu, Ducimetiere, Pierre, Empana, Jean Philippe, Bokemark, Lena, Bergstroem, Goeran, Schmidt, Caroline, Castelnuovo, Samuela, Calabresi, Laura D., Norata, Giuseppe, Grigore, Liliana, Catapano, Alberico, Zhao, Dong, Wang, Miao, Liu, Jing, Ikram, M. Arfan, Kavousi, Maryam L., Bots, Michiel J., Sweeting, Michael W., Lorenz, Matthias, and Willeit, Peter

Abstract

Background: The association between common carotid artery intima-media thickness (CCA-IMT) and incident carotid plaque has not been characterized fully. We therefore aimed to precisely quantify the relationship between CCA-IMT and carotid plaque development. Methods and Results: We undertook an individual participant data meta-analysis of 20 prospective studies from the Proof-ATHERO (Prospective Studies of Atherosclerosis) consortium that recorded baseline CCA-IMT and incident carotid plaque involving 21 494 individuals without a history of cardiovascular disease and without preexisting carotid plaque at baseline. Mean baseline age was 56 years (SD, 9 years), 55% were women, and mean baseline CCA-IMT was 0.71 mm (SD, 0.17 mm). Over a median follow-up of 5.9 years (5th-95th percentile, 1.9-19.0 years), 8278 individuals developed first-ever carotid plaque. We combined study-specific odds ratios (ORs) for incident carotid plaque using random-effects meta-analysis. Baseline CCA-IMT was approximately log-linearly associated with the odds of developing carotid plaque. The age-, sex-, and trial arm-adjusted OR for carotid plaque per SD higher baseline CCA-IMT was 1.40 (95% CI, 1.31-1.50; I-2=63.9%). The corresponding OR that was further adjusted for ethnicity, smoking, diabetes, body mass index, systolic blood pressure, low- and high-density lipoprotein cholesterol, and lipid-lowering and antihypertensive medication was 1.34 (95% CI, 1.24-1.45; I-2=59.4%; 14 studies; 16 297 participants; 6381 incident plaques). We observed no significant effect modification across clinically relevant subgroups. Sensitivity analysis restricted to studies defining plaque as focal thickening yielded a comparable OR (1.38 [95% CI, 1.29-1.47]; I-2=57.1%; 14 studies; 17 352 participants; 6991 incident plaques). Conclusions: Our large-scale individual participant data meta-analysis demonstrated that CCA-IMT is associated with the long-term risk of developing first-ever carotid plaque, independent

Published
2023
Full Text
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4. Association of Intima-Media Thickness Measured at the Common Carotid Artery With Incident Carotid Plaque : Individual Participant Data Meta-Analysis of 20 Prospective Studies

Author

Tschiderer, Lena, Seekircher, Lisa, Izzo, Raffaele, Mancusi, Costantino V., Manzi, Maria, Baldassarre, Damiano, Amato, Mauro, Tremoli, Elena, Veglia, Fabrizio, Tuomainen, Tomi-Pekka, Kauhanen, Jussi, Voutilainen, Ari, Iglseder, Bernhard, Lind, Lars, Rundek, Tatjana, Desvarieux, Moise, Kato, Akihiko, de Groot, Eric, Asci, Guelay, Ok, Ercan, Agewall, Stefan, Beulens, Joline W. J. D., Byrne, Christopher C., Calder, Philip C., Gerstein, Hertzel, Gresele, Paolo, Klingenschmid, Gerhard, Nagai, Michiaki H., Olsen, Michael, Parraga, Grace S., Safarova, Maya, Sattar, Naveed, Skilton, Michael, Stehouwer, Coen D. A., Uthoff, Heiko A., van Agtmael, Michiel A., van der Heijden, Amber A., Zozulinska-Ziolkiewicz, Dorota, Park, Hyun-Woong, Lee, Moo-Sik, Bae, Jang-Ho, Beloqui, Oscar F., Landecho, Manuel, Plichart, Matthieu, Ducimetiere, Pierre, Empana, Jean Philippe, Bokemark, Lena, Bergstroem, Goeran, Schmidt, Caroline, Castelnuovo, Samuela, Calabresi, Laura D., Norata, Giuseppe, Grigore, Liliana, Catapano, Alberico, Zhao, Dong, Wang, Miao, Liu, Jing, Ikram, M. Arfan, Kavousi, Maryam L., Bots, Michiel J., Sweeting, Michael W., Lorenz, Matthias, Willeit, Peter, Tschiderer, Lena, Seekircher, Lisa, Izzo, Raffaele, Mancusi, Costantino V., Manzi, Maria, Baldassarre, Damiano, Amato, Mauro, Tremoli, Elena, Veglia, Fabrizio, Tuomainen, Tomi-Pekka, Kauhanen, Jussi, Voutilainen, Ari, Iglseder, Bernhard, Lind, Lars, Rundek, Tatjana, Desvarieux, Moise, Kato, Akihiko, de Groot, Eric, Asci, Guelay, Ok, Ercan, Agewall, Stefan, Beulens, Joline W. J. D., Byrne, Christopher C., Calder, Philip C., Gerstein, Hertzel, Gresele, Paolo, Klingenschmid, Gerhard, Nagai, Michiaki H., Olsen, Michael, Parraga, Grace S., Safarova, Maya, Sattar, Naveed, Skilton, Michael, Stehouwer, Coen D. A., Uthoff, Heiko A., van Agtmael, Michiel A., van der Heijden, Amber A., Zozulinska-Ziolkiewicz, Dorota, Park, Hyun-Woong, Lee, Moo-Sik, Bae, Jang-Ho, Beloqui, Oscar F., Landecho, Manuel, Plichart, Matthieu, Ducimetiere, Pierre, Empana, Jean Philippe, Bokemark, Lena, Bergstroem, Goeran, Schmidt, Caroline, Castelnuovo, Samuela, Calabresi, Laura D., Norata, Giuseppe, Grigore, Liliana, Catapano, Alberico, Zhao, Dong, Wang, Miao, Liu, Jing, Ikram, M. Arfan, Kavousi, Maryam L., Bots, Michiel J., Sweeting, Michael W., Lorenz, Matthias, and Willeit, Peter

Abstract

Background: The association between common carotid artery intima-media thickness (CCA-IMT) and incident carotid plaque has not been characterized fully. We therefore aimed to precisely quantify the relationship between CCA-IMT and carotid plaque development. Methods and Results: We undertook an individual participant data meta-analysis of 20 prospective studies from the Proof-ATHERO (Prospective Studies of Atherosclerosis) consortium that recorded baseline CCA-IMT and incident carotid plaque involving 21 494 individuals without a history of cardiovascular disease and without preexisting carotid plaque at baseline. Mean baseline age was 56 years (SD, 9 years), 55% were women, and mean baseline CCA-IMT was 0.71 mm (SD, 0.17 mm). Over a median follow-up of 5.9 years (5th-95th percentile, 1.9-19.0 years), 8278 individuals developed first-ever carotid plaque. We combined study-specific odds ratios (ORs) for incident carotid plaque using random-effects meta-analysis. Baseline CCA-IMT was approximately log-linearly associated with the odds of developing carotid plaque. The age-, sex-, and trial arm-adjusted OR for carotid plaque per SD higher baseline CCA-IMT was 1.40 (95% CI, 1.31-1.50; I-2=63.9%). The corresponding OR that was further adjusted for ethnicity, smoking, diabetes, body mass index, systolic blood pressure, low- and high-density lipoprotein cholesterol, and lipid-lowering and antihypertensive medication was 1.34 (95% CI, 1.24-1.45; I-2=59.4%; 14 studies; 16 297 participants; 6381 incident plaques). We observed no significant effect modification across clinically relevant subgroups. Sensitivity analysis restricted to studies defining plaque as focal thickening yielded a comparable OR (1.38 [95% CI, 1.29-1.47]; I-2=57.1%; 14 studies; 17 352 participants; 6991 incident plaques). Conclusions: Our large-scale individual participant data meta-analysis demonstrated that CCA-IMT is associated with the long-term risk of developing first-ever carotid plaque, independent

Published
2023
Full Text
View/download PDF

5. Association of Intima-Media Thickness Measured at the Common Carotid Artery With Incident Carotid Plaque : Individual Participant Data Meta-Analysis of 20 Prospective Studies

Author

Tschiderer, Lena, Seekircher, Lisa, Izzo, Raffaele, Mancusi, Costantino V., Manzi, Maria, Baldassarre, Damiano, Amato, Mauro, Tremoli, Elena, Veglia, Fabrizio, Tuomainen, Tomi-Pekka, Kauhanen, Jussi, Voutilainen, Ari, Iglseder, Bernhard, Lind, Lars, Rundek, Tatjana, Desvarieux, Moise, Kato, Akihiko, de Groot, Eric, Asci, Guelay, Ok, Ercan, Agewall, Stefan, Beulens, Joline W. J. D., Byrne, Christopher C., Calder, Philip C., Gerstein, Hertzel, Gresele, Paolo, Klingenschmid, Gerhard, Nagai, Michiaki H., Olsen, Michael, Parraga, Grace S., Safarova, Maya, Sattar, Naveed, Skilton, Michael, Stehouwer, Coen D. A., Uthoff, Heiko A., van Agtmael, Michiel A., van der Heijden, Amber A., Zozulinska-Ziolkiewicz, Dorota, Park, Hyun-Woong, Lee, Moo-Sik, Bae, Jang-Ho, Beloqui, Oscar F., Landecho, Manuel, Plichart, Matthieu, Ducimetiere, Pierre, Empana, Jean Philippe, Bokemark, Lena, Bergstroem, Goeran, Schmidt, Caroline, Castelnuovo, Samuela, Calabresi, Laura D., Norata, Giuseppe, Grigore, Liliana, Catapano, Alberico, Zhao, Dong, Wang, Miao, Liu, Jing, Ikram, M. Arfan, Kavousi, Maryam L., Bots, Michiel J., Sweeting, Michael W., Lorenz, Matthias, Willeit, Peter, Tschiderer, Lena, Seekircher, Lisa, Izzo, Raffaele, Mancusi, Costantino V., Manzi, Maria, Baldassarre, Damiano, Amato, Mauro, Tremoli, Elena, Veglia, Fabrizio, Tuomainen, Tomi-Pekka, Kauhanen, Jussi, Voutilainen, Ari, Iglseder, Bernhard, Lind, Lars, Rundek, Tatjana, Desvarieux, Moise, Kato, Akihiko, de Groot, Eric, Asci, Guelay, Ok, Ercan, Agewall, Stefan, Beulens, Joline W. J. D., Byrne, Christopher C., Calder, Philip C., Gerstein, Hertzel, Gresele, Paolo, Klingenschmid, Gerhard, Nagai, Michiaki H., Olsen, Michael, Parraga, Grace S., Safarova, Maya, Sattar, Naveed, Skilton, Michael, Stehouwer, Coen D. A., Uthoff, Heiko A., van Agtmael, Michiel A., van der Heijden, Amber A., Zozulinska-Ziolkiewicz, Dorota, Park, Hyun-Woong, Lee, Moo-Sik, Bae, Jang-Ho, Beloqui, Oscar F., Landecho, Manuel, Plichart, Matthieu, Ducimetiere, Pierre, Empana, Jean Philippe, Bokemark, Lena, Bergstroem, Goeran, Schmidt, Caroline, Castelnuovo, Samuela, Calabresi, Laura D., Norata, Giuseppe, Grigore, Liliana, Catapano, Alberico, Zhao, Dong, Wang, Miao, Liu, Jing, Ikram, M. Arfan, Kavousi, Maryam L., Bots, Michiel J., Sweeting, Michael W., Lorenz, Matthias, and Willeit, Peter

Abstract

Background: The association between common carotid artery intima-media thickness (CCA-IMT) and incident carotid plaque has not been characterized fully. We therefore aimed to precisely quantify the relationship between CCA-IMT and carotid plaque development. Methods and Results: We undertook an individual participant data meta-analysis of 20 prospective studies from the Proof-ATHERO (Prospective Studies of Atherosclerosis) consortium that recorded baseline CCA-IMT and incident carotid plaque involving 21 494 individuals without a history of cardiovascular disease and without preexisting carotid plaque at baseline. Mean baseline age was 56 years (SD, 9 years), 55% were women, and mean baseline CCA-IMT was 0.71 mm (SD, 0.17 mm). Over a median follow-up of 5.9 years (5th-95th percentile, 1.9-19.0 years), 8278 individuals developed first-ever carotid plaque. We combined study-specific odds ratios (ORs) for incident carotid plaque using random-effects meta-analysis. Baseline CCA-IMT was approximately log-linearly associated with the odds of developing carotid plaque. The age-, sex-, and trial arm-adjusted OR for carotid plaque per SD higher baseline CCA-IMT was 1.40 (95% CI, 1.31-1.50; I-2=63.9%). The corresponding OR that was further adjusted for ethnicity, smoking, diabetes, body mass index, systolic blood pressure, low- and high-density lipoprotein cholesterol, and lipid-lowering and antihypertensive medication was 1.34 (95% CI, 1.24-1.45; I-2=59.4%; 14 studies; 16 297 participants; 6381 incident plaques). We observed no significant effect modification across clinically relevant subgroups. Sensitivity analysis restricted to studies defining plaque as focal thickening yielded a comparable OR (1.38 [95% CI, 1.29-1.47]; I-2=57.1%; 14 studies; 17 352 participants; 6991 incident plaques). Conclusions: Our large-scale individual participant data meta-analysis demonstrated that CCA-IMT is associated with the long-term risk of developing first-ever carotid plaque, independent

Published
2023
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6. Progression of conventional cardiovascular risk factors and vascular disease risk in individuals : insights from the PROG-IMT consortium

Author

Bahls, Martin, Lorenz, Matthias W., Doerr, Marcus, Gao, Lu, Kitagawa, Kazuo, Tuomainen, Tomi-Pekka, Agewall, Stefan, Berenson, Gerald, Catapano, Alberico L., Norata, Giuseppe D., Bots, Michiel L., van Gilst, Wiek, Asselbergs, Folkert W., Brouwers, Frank P., Uthoff, Heiko, Sander, Dirk, Poppert, Holger, Olsen, Michael Hecht, Empana, Jean Philippe, Schminke, Ulf, Baldassarre, Damiano, Veglia, Fabrizio, Franco, Oscar H., Kavousi, Maryam, de Groot, Eric, Mathiesen, Ellisiv B., Grigore, Liliana, Polak, Joseph F., Rundek, Tatjana, Stehouwer, Coen D. A., Skilton, Michael R., Hatzitolios, Apostolos, I, Savopoulos, Christos, Ntaios, George, Plichart, Matthieu, McLachlan, Stela, Lind, Lars, Willeit, Peter, Steinmetz, Helmuth, Desvarieux, Moise, Ikram, M. Arfan, Johnsen, Stein Harald, Schmidt, Caroline, Willeit, Johann, Ducimetiere, Pierre, Price, Jackie F., Bergstrom, Goran, Kauhanen, Jussi, Kiechl, Stefan, Sitzer, Matthias, Bickel, Horst, Sacco, Ralph L., Hofman, Albert, Voelzke, Henry, Thompson, Simon G., Bahls, Martin, Lorenz, Matthias W., Doerr, Marcus, Gao, Lu, Kitagawa, Kazuo, Tuomainen, Tomi-Pekka, Agewall, Stefan, Berenson, Gerald, Catapano, Alberico L., Norata, Giuseppe D., Bots, Michiel L., van Gilst, Wiek, Asselbergs, Folkert W., Brouwers, Frank P., Uthoff, Heiko, Sander, Dirk, Poppert, Holger, Olsen, Michael Hecht, Empana, Jean Philippe, Schminke, Ulf, Baldassarre, Damiano, Veglia, Fabrizio, Franco, Oscar H., Kavousi, Maryam, de Groot, Eric, Mathiesen, Ellisiv B., Grigore, Liliana, Polak, Joseph F., Rundek, Tatjana, Stehouwer, Coen D. A., Skilton, Michael R., Hatzitolios, Apostolos, I, Savopoulos, Christos, Ntaios, George, Plichart, Matthieu, McLachlan, Stela, Lind, Lars, Willeit, Peter, Steinmetz, Helmuth, Desvarieux, Moise, Ikram, M. Arfan, Johnsen, Stein Harald, Schmidt, Caroline, Willeit, Johann, Ducimetiere, Pierre, Price, Jackie F., Bergstrom, Goran, Kauhanen, Jussi, Kiechl, Stefan, Sitzer, Matthias, Bickel, Horst, Sacco, Ralph L., Hofman, Albert, Voelzke, Henry, and Thompson, Simon G.

Abstract

Aims Averaged measurements, but not the progression based on multiple assessments of carotid intima-media thickness, (cIMT) are predictive of cardiovascular disease (CVD) events in individuals. Whether this is true for conventional risk factors is unclear. Methods and results An individual participant meta-analysis was used to associate the annualised progression of systolic blood pressure, total cholesterol, low-density lipoprotein cholesterol and high-density lipoprotein cholesterol with future cardiovascular disease risk in 13 prospective cohort studies of the PROG-IMT collaboration (n = 34,072). Follow-up data included information on a combined cardiovascular disease endpoint of myocardial infarction, stroke, or vascular death. In secondary analyses, annualised progression was replaced with average. Log hazard ratios per standard deviation difference were pooled across studies by a random effects meta-analysis. In primary analysis, the annualised progression of total cholesterol was marginally related to a higher cardiovascular disease risk (hazard ratio (HR) 1.04, 95% confidence interval (CI) 1.00 to 1.07). The annualised progression of systolic blood pressure, low-density lipoprotein cholesterol and high-density lipoprotein cholesterol was not associated with future cardiovascular disease risk. In secondary analysis, average systolic blood pressure (HR 1.20 95% CI 1.11 to 1.29) and low-density lipoprotein cholesterol (HR 1.09, 95% CI 1.02 to 1.16) were related to a greater, while high-density lipoprotein cholesterol (HR 0.92, 95% CI 0.88 to 0.97) was related to a lower risk of future cardiovascular disease events. Conclusion Averaged measurements of systolic blood pressure, low-density lipoprotein cholesterol and high-density lipoprotein cholesterol displayed significant linear relationships with the risk of future cardiovascular disease events. However, there was no clear association between the annualised progression of these conventional risk factors in ind

Published
2020
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7. Progression of conventional cardiovascular risk factors and vascular disease risk in individuals : insights from the PROG-IMT consortium

Author

Bahls, Martin, Lorenz, Matthias W., Doerr, Marcus, Gao, Lu, Kitagawa, Kazuo, Tuomainen, Tomi-Pekka, Agewall, Stefan, Berenson, Gerald, Catapano, Alberico L., Norata, Giuseppe D., Bots, Michiel L., van Gilst, Wiek, Asselbergs, Folkert W., Brouwers, Frank P., Uthoff, Heiko, Sander, Dirk, Poppert, Holger, Olsen, Michael Hecht, Empana, Jean Philippe, Schminke, Ulf, Baldassarre, Damiano, Veglia, Fabrizio, Franco, Oscar H., Kavousi, Maryam, de Groot, Eric, Mathiesen, Ellisiv B., Grigore, Liliana, Polak, Joseph F., Rundek, Tatjana, Stehouwer, Coen D. A., Skilton, Michael R., Hatzitolios, Apostolos, I, Savopoulos, Christos, Ntaios, George, Plichart, Matthieu, McLachlan, Stela, Lind, Lars, Willeit, Peter, Steinmetz, Helmuth, Desvarieux, Moise, Ikram, M. Arfan, Johnsen, Stein Harald, Schmidt, Caroline, Willeit, Johann, Ducimetiere, Pierre, Price, Jackie F., Bergstrom, Goran, Kauhanen, Jussi, Kiechl, Stefan, Sitzer, Matthias, Bickel, Horst, Sacco, Ralph L., Hofman, Albert, Voelzke, Henry, Thompson, Simon G., Bahls, Martin, Lorenz, Matthias W., Doerr, Marcus, Gao, Lu, Kitagawa, Kazuo, Tuomainen, Tomi-Pekka, Agewall, Stefan, Berenson, Gerald, Catapano, Alberico L., Norata, Giuseppe D., Bots, Michiel L., van Gilst, Wiek, Asselbergs, Folkert W., Brouwers, Frank P., Uthoff, Heiko, Sander, Dirk, Poppert, Holger, Olsen, Michael Hecht, Empana, Jean Philippe, Schminke, Ulf, Baldassarre, Damiano, Veglia, Fabrizio, Franco, Oscar H., Kavousi, Maryam, de Groot, Eric, Mathiesen, Ellisiv B., Grigore, Liliana, Polak, Joseph F., Rundek, Tatjana, Stehouwer, Coen D. A., Skilton, Michael R., Hatzitolios, Apostolos, I, Savopoulos, Christos, Ntaios, George, Plichart, Matthieu, McLachlan, Stela, Lind, Lars, Willeit, Peter, Steinmetz, Helmuth, Desvarieux, Moise, Ikram, M. Arfan, Johnsen, Stein Harald, Schmidt, Caroline, Willeit, Johann, Ducimetiere, Pierre, Price, Jackie F., Bergstrom, Goran, Kauhanen, Jussi, Kiechl, Stefan, Sitzer, Matthias, Bickel, Horst, Sacco, Ralph L., Hofman, Albert, Voelzke, Henry, and Thompson, Simon G.

Abstract

Aims Averaged measurements, but not the progression based on multiple assessments of carotid intima-media thickness, (cIMT) are predictive of cardiovascular disease (CVD) events in individuals. Whether this is true for conventional risk factors is unclear. Methods and results An individual participant meta-analysis was used to associate the annualised progression of systolic blood pressure, total cholesterol, low-density lipoprotein cholesterol and high-density lipoprotein cholesterol with future cardiovascular disease risk in 13 prospective cohort studies of the PROG-IMT collaboration (n = 34,072). Follow-up data included information on a combined cardiovascular disease endpoint of myocardial infarction, stroke, or vascular death. In secondary analyses, annualised progression was replaced with average. Log hazard ratios per standard deviation difference were pooled across studies by a random effects meta-analysis. In primary analysis, the annualised progression of total cholesterol was marginally related to a higher cardiovascular disease risk (hazard ratio (HR) 1.04, 95% confidence interval (CI) 1.00 to 1.07). The annualised progression of systolic blood pressure, low-density lipoprotein cholesterol and high-density lipoprotein cholesterol was not associated with future cardiovascular disease risk. In secondary analysis, average systolic blood pressure (HR 1.20 95% CI 1.11 to 1.29) and low-density lipoprotein cholesterol (HR 1.09, 95% CI 1.02 to 1.16) were related to a greater, while high-density lipoprotein cholesterol (HR 0.92, 95% CI 0.88 to 0.97) was related to a lower risk of future cardiovascular disease events. Conclusion Averaged measurements of systolic blood pressure, low-density lipoprotein cholesterol and high-density lipoprotein cholesterol displayed significant linear relationships with the risk of future cardiovascular disease events. However, there was no clear association between the annualised progression of these conventional risk factors in ind

Published
2020
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8. Progression of conventional cardiovascular risk factors and vascular disease risk in individuals : insights from the PROG-IMT consortium

Author

Bahls, Martin, Lorenz, Matthias W., Doerr, Marcus, Gao, Lu, Kitagawa, Kazuo, Tuomainen, Tomi-Pekka, Agewall, Stefan, Berenson, Gerald, Catapano, Alberico L., Norata, Giuseppe D., Bots, Michiel L., van Gilst, Wiek, Asselbergs, Folkert W., Brouwers, Frank P., Uthoff, Heiko, Sander, Dirk, Poppert, Holger, Olsen, Michael Hecht, Empana, Jean Philippe, Schminke, Ulf, Baldassarre, Damiano, Veglia, Fabrizio, Franco, Oscar H., Kavousi, Maryam, de Groot, Eric, Mathiesen, Ellisiv B., Grigore, Liliana, Polak, Joseph F., Rundek, Tatjana, Stehouwer, Coen D. A., Skilton, Michael R., Hatzitolios, Apostolos, I, Savopoulos, Christos, Ntaios, George, Plichart, Matthieu, McLachlan, Stela, Lind, Lars, Willeit, Peter, Steinmetz, Helmuth, Desvarieux, Moise, Ikram, M. Arfan, Johnsen, Stein Harald, Schmidt, Caroline, Willeit, Johann, Ducimetiere, Pierre, Price, Jackie F., Bergstrom, Goran, Kauhanen, Jussi, Kiechl, Stefan, Sitzer, Matthias, Bickel, Horst, Sacco, Ralph L., Hofman, Albert, Voelzke, Henry, Thompson, Simon G., Bahls, Martin, Lorenz, Matthias W., Doerr, Marcus, Gao, Lu, Kitagawa, Kazuo, Tuomainen, Tomi-Pekka, Agewall, Stefan, Berenson, Gerald, Catapano, Alberico L., Norata, Giuseppe D., Bots, Michiel L., van Gilst, Wiek, Asselbergs, Folkert W., Brouwers, Frank P., Uthoff, Heiko, Sander, Dirk, Poppert, Holger, Olsen, Michael Hecht, Empana, Jean Philippe, Schminke, Ulf, Baldassarre, Damiano, Veglia, Fabrizio, Franco, Oscar H., Kavousi, Maryam, de Groot, Eric, Mathiesen, Ellisiv B., Grigore, Liliana, Polak, Joseph F., Rundek, Tatjana, Stehouwer, Coen D. A., Skilton, Michael R., Hatzitolios, Apostolos, I, Savopoulos, Christos, Ntaios, George, Plichart, Matthieu, McLachlan, Stela, Lind, Lars, Willeit, Peter, Steinmetz, Helmuth, Desvarieux, Moise, Ikram, M. Arfan, Johnsen, Stein Harald, Schmidt, Caroline, Willeit, Johann, Ducimetiere, Pierre, Price, Jackie F., Bergstrom, Goran, Kauhanen, Jussi, Kiechl, Stefan, Sitzer, Matthias, Bickel, Horst, Sacco, Ralph L., Hofman, Albert, Voelzke, Henry, and Thompson, Simon G.

Abstract

Aims Averaged measurements, but not the progression based on multiple assessments of carotid intima-media thickness, (cIMT) are predictive of cardiovascular disease (CVD) events in individuals. Whether this is true for conventional risk factors is unclear. Methods and results An individual participant meta-analysis was used to associate the annualised progression of systolic blood pressure, total cholesterol, low-density lipoprotein cholesterol and high-density lipoprotein cholesterol with future cardiovascular disease risk in 13 prospective cohort studies of the PROG-IMT collaboration (n = 34,072). Follow-up data included information on a combined cardiovascular disease endpoint of myocardial infarction, stroke, or vascular death. In secondary analyses, annualised progression was replaced with average. Log hazard ratios per standard deviation difference were pooled across studies by a random effects meta-analysis. In primary analysis, the annualised progression of total cholesterol was marginally related to a higher cardiovascular disease risk (hazard ratio (HR) 1.04, 95% confidence interval (CI) 1.00 to 1.07). The annualised progression of systolic blood pressure, low-density lipoprotein cholesterol and high-density lipoprotein cholesterol was not associated with future cardiovascular disease risk. In secondary analysis, average systolic blood pressure (HR 1.20 95% CI 1.11 to 1.29) and low-density lipoprotein cholesterol (HR 1.09, 95% CI 1.02 to 1.16) were related to a greater, while high-density lipoprotein cholesterol (HR 0.92, 95% CI 0.88 to 0.97) was related to a lower risk of future cardiovascular disease events. Conclusion Averaged measurements of systolic blood pressure, low-density lipoprotein cholesterol and high-density lipoprotein cholesterol displayed significant linear relationships with the risk of future cardiovascular disease events. However, there was no clear association between the annualised progression of these conventional risk factors in ind

Published
2020
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9. Progression of conventional cardiovascular risk factors and vascular disease risk in individuals : insights from the PROG-IMT consortium

Author

Bahls, Martin, Lorenz, Matthias W., Doerr, Marcus, Gao, Lu, Kitagawa, Kazuo, Tuomainen, Tomi-Pekka, Agewall, Stefan, Berenson, Gerald, Catapano, Alberico L., Norata, Giuseppe D., Bots, Michiel L., van Gilst, Wiek, Asselbergs, Folkert W., Brouwers, Frank P., Uthoff, Heiko, Sander, Dirk, Poppert, Holger, Olsen, Michael Hecht, Empana, Jean Philippe, Schminke, Ulf, Baldassarre, Damiano, Veglia, Fabrizio, Franco, Oscar H., Kavousi, Maryam, de Groot, Eric, Mathiesen, Ellisiv B., Grigore, Liliana, Polak, Joseph F., Rundek, Tatjana, Stehouwer, Coen D. A., Skilton, Michael R., Hatzitolios, Apostolos, I, Savopoulos, Christos, Ntaios, George, Plichart, Matthieu, McLachlan, Stela, Lind, Lars, Willeit, Peter, Steinmetz, Helmuth, Desvarieux, Moise, Ikram, M. Arfan, Johnsen, Stein Harald, Schmidt, Caroline, Willeit, Johann, Ducimetiere, Pierre, Price, Jackie F., Bergstrom, Goran, Kauhanen, Jussi, Kiechl, Stefan, Sitzer, Matthias, Bickel, Horst, Sacco, Ralph L., Hofman, Albert, Voelzke, Henry, Thompson, Simon G., Bahls, Martin, Lorenz, Matthias W., Doerr, Marcus, Gao, Lu, Kitagawa, Kazuo, Tuomainen, Tomi-Pekka, Agewall, Stefan, Berenson, Gerald, Catapano, Alberico L., Norata, Giuseppe D., Bots, Michiel L., van Gilst, Wiek, Asselbergs, Folkert W., Brouwers, Frank P., Uthoff, Heiko, Sander, Dirk, Poppert, Holger, Olsen, Michael Hecht, Empana, Jean Philippe, Schminke, Ulf, Baldassarre, Damiano, Veglia, Fabrizio, Franco, Oscar H., Kavousi, Maryam, de Groot, Eric, Mathiesen, Ellisiv B., Grigore, Liliana, Polak, Joseph F., Rundek, Tatjana, Stehouwer, Coen D. A., Skilton, Michael R., Hatzitolios, Apostolos, I, Savopoulos, Christos, Ntaios, George, Plichart, Matthieu, McLachlan, Stela, Lind, Lars, Willeit, Peter, Steinmetz, Helmuth, Desvarieux, Moise, Ikram, M. Arfan, Johnsen, Stein Harald, Schmidt, Caroline, Willeit, Johann, Ducimetiere, Pierre, Price, Jackie F., Bergstrom, Goran, Kauhanen, Jussi, Kiechl, Stefan, Sitzer, Matthias, Bickel, Horst, Sacco, Ralph L., Hofman, Albert, Voelzke, Henry, and Thompson, Simon G.

Abstract

Aims Averaged measurements, but not the progression based on multiple assessments of carotid intima-media thickness, (cIMT) are predictive of cardiovascular disease (CVD) events in individuals. Whether this is true for conventional risk factors is unclear. Methods and results An individual participant meta-analysis was used to associate the annualised progression of systolic blood pressure, total cholesterol, low-density lipoprotein cholesterol and high-density lipoprotein cholesterol with future cardiovascular disease risk in 13 prospective cohort studies of the PROG-IMT collaboration (n = 34,072). Follow-up data included information on a combined cardiovascular disease endpoint of myocardial infarction, stroke, or vascular death. In secondary analyses, annualised progression was replaced with average. Log hazard ratios per standard deviation difference were pooled across studies by a random effects meta-analysis. In primary analysis, the annualised progression of total cholesterol was marginally related to a higher cardiovascular disease risk (hazard ratio (HR) 1.04, 95% confidence interval (CI) 1.00 to 1.07). The annualised progression of systolic blood pressure, low-density lipoprotein cholesterol and high-density lipoprotein cholesterol was not associated with future cardiovascular disease risk. In secondary analysis, average systolic blood pressure (HR 1.20 95% CI 1.11 to 1.29) and low-density lipoprotein cholesterol (HR 1.09, 95% CI 1.02 to 1.16) were related to a greater, while high-density lipoprotein cholesterol (HR 0.92, 95% CI 0.88 to 0.97) was related to a lower risk of future cardiovascular disease events. Conclusion Averaged measurements of systolic blood pressure, low-density lipoprotein cholesterol and high-density lipoprotein cholesterol displayed significant linear relationships with the risk of future cardiovascular disease events. However, there was no clear association between the annualised progression of these conventional risk factors in ind

Published
2020
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10. Progression of conventional cardiovascular risk factors and vascular disease risk in individuals : insights from the PROG-IMT consortium

Author

Bahls, Martin, Lorenz, Matthias W., Doerr, Marcus, Gao, Lu, Kitagawa, Kazuo, Tuomainen, Tomi-Pekka, Agewall, Stefan, Berenson, Gerald, Catapano, Alberico L., Norata, Giuseppe D., Bots, Michiel L., van Gilst, Wiek, Asselbergs, Folkert W., Brouwers, Frank P., Uthoff, Heiko, Sander, Dirk, Poppert, Holger, Olsen, Michael Hecht, Empana, Jean Philippe, Schminke, Ulf, Baldassarre, Damiano, Veglia, Fabrizio, Franco, Oscar H., Kavousi, Maryam, de Groot, Eric, Mathiesen, Ellisiv B., Grigore, Liliana, Polak, Joseph F., Rundek, Tatjana, Stehouwer, Coen D. A., Skilton, Michael R., Hatzitolios, Apostolos, I, Savopoulos, Christos, Ntaios, George, Plichart, Matthieu, McLachlan, Stela, Lind, Lars, Willeit, Peter, Steinmetz, Helmuth, Desvarieux, Moise, Ikram, M. Arfan, Johnsen, Stein Harald, Schmidt, Caroline, Willeit, Johann, Ducimetiere, Pierre, Price, Jackie F., Bergstrom, Goran, Kauhanen, Jussi, Kiechl, Stefan, Sitzer, Matthias, Bickel, Horst, Sacco, Ralph L., Hofman, Albert, Voelzke, Henry, Thompson, Simon G., Bahls, Martin, Lorenz, Matthias W., Doerr, Marcus, Gao, Lu, Kitagawa, Kazuo, Tuomainen, Tomi-Pekka, Agewall, Stefan, Berenson, Gerald, Catapano, Alberico L., Norata, Giuseppe D., Bots, Michiel L., van Gilst, Wiek, Asselbergs, Folkert W., Brouwers, Frank P., Uthoff, Heiko, Sander, Dirk, Poppert, Holger, Olsen, Michael Hecht, Empana, Jean Philippe, Schminke, Ulf, Baldassarre, Damiano, Veglia, Fabrizio, Franco, Oscar H., Kavousi, Maryam, de Groot, Eric, Mathiesen, Ellisiv B., Grigore, Liliana, Polak, Joseph F., Rundek, Tatjana, Stehouwer, Coen D. A., Skilton, Michael R., Hatzitolios, Apostolos, I, Savopoulos, Christos, Ntaios, George, Plichart, Matthieu, McLachlan, Stela, Lind, Lars, Willeit, Peter, Steinmetz, Helmuth, Desvarieux, Moise, Ikram, M. Arfan, Johnsen, Stein Harald, Schmidt, Caroline, Willeit, Johann, Ducimetiere, Pierre, Price, Jackie F., Bergstrom, Goran, Kauhanen, Jussi, Kiechl, Stefan, Sitzer, Matthias, Bickel, Horst, Sacco, Ralph L., Hofman, Albert, Voelzke, Henry, and Thompson, Simon G.

Abstract

Aims Averaged measurements, but not the progression based on multiple assessments of carotid intima-media thickness, (cIMT) are predictive of cardiovascular disease (CVD) events in individuals. Whether this is true for conventional risk factors is unclear. Methods and results An individual participant meta-analysis was used to associate the annualised progression of systolic blood pressure, total cholesterol, low-density lipoprotein cholesterol and high-density lipoprotein cholesterol with future cardiovascular disease risk in 13 prospective cohort studies of the PROG-IMT collaboration (n = 34,072). Follow-up data included information on a combined cardiovascular disease endpoint of myocardial infarction, stroke, or vascular death. In secondary analyses, annualised progression was replaced with average. Log hazard ratios per standard deviation difference were pooled across studies by a random effects meta-analysis. In primary analysis, the annualised progression of total cholesterol was marginally related to a higher cardiovascular disease risk (hazard ratio (HR) 1.04, 95% confidence interval (CI) 1.00 to 1.07). The annualised progression of systolic blood pressure, low-density lipoprotein cholesterol and high-density lipoprotein cholesterol was not associated with future cardiovascular disease risk. In secondary analysis, average systolic blood pressure (HR 1.20 95% CI 1.11 to 1.29) and low-density lipoprotein cholesterol (HR 1.09, 95% CI 1.02 to 1.16) were related to a greater, while high-density lipoprotein cholesterol (HR 0.92, 95% CI 0.88 to 0.97) was related to a lower risk of future cardiovascular disease events. Conclusion Averaged measurements of systolic blood pressure, low-density lipoprotein cholesterol and high-density lipoprotein cholesterol displayed significant linear relationships with the risk of future cardiovascular disease events. However, there was no clear association between the annualised progression of these conventional risk factors in ind

Published
2020
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11. Predictive value for cardiovascular events of common carotid intima media thickness and its rate of change in individuals at high cardiovascular risk - Results from the PROG-IMT collaboration

Author

Lorenz, Matthias W., Gao, Lu, Ziegelbauer, Kathrin, Norata, Giuseppe Danilo, Empana, Jean Philippe, Schmidtmann, Irene, Lin, Hung-Ju, McLachlan, Stela, Bokemark, Lena, Ronkainen, Kimmo, Amato, Mauro, Schminke, Ulf, Srinivasan, Sathanur R., Lind, Lars, Okazaki, Shuhei, Stehouwer, Coen D. A., Willeit, Peter, Polak, Joseph F., Steinmetz, Helmuth, Sander, Dirk, Poppert, Holger, Desvarieux, Moise, Ikram, M. Arfan, Johnsen, Stein Harald, Staub, Daniel, Sirtori, Cesare R., Igiseder, Bernhard, Beloqui, Oscar, Engstrom, Gunnar, Friera, Alfonso, Rozza, Francesco, Xie, Wuxiang, Parraga, Grace, Grigore, Liliana, Plichart, Matthieu, Blankenberg, Stefan, Su, Ta-Chen, Schmidt, Caroline, Tuomainen, Tomi-Pekka, Veglia, Fabrizio, Voelzke, Henry, Nijpels, Giel, Willeit, Johann, Sacco, Ralph L., Franco, Oscar H., Uthoff, Heiko, Hedblad, Bo, Suarez, Carmen, Izzo, Raffaele, Zhao, Dong, Wannarong, Thapat, Catapano, Alberico, Ducimetiere, Pierre, Espinola-Klein, Christine, Chien, Kuo-Liong, Price, Jackie F., Bergstrom, Goren, Kauhanen, Jussi, Tremoli, Elena, Doerr, Marcus, Berenson, Gerald, Kitagawa, Kazuo, Dekker, Jacqueline M., Kiechl, Stefan, Sitzer, Matthias, Bickel, Horst, Rundek, Tatjana, Hofman, Albert, Mathiesen, Ellisiv B., Castelnuovo, Samuela, Landecho, Manuel F., Rosvall, Maria, Gabriel, Rafael, de Luca, Nicola, Liu, Jing, Baldassarre, Damiano, Kavousi, Maryam, de Groot, Eric, Bots, Michiel L., Yanez, David N., Thompson, Simon G., Lorenz, Matthias W., Gao, Lu, Ziegelbauer, Kathrin, Norata, Giuseppe Danilo, Empana, Jean Philippe, Schmidtmann, Irene, Lin, Hung-Ju, McLachlan, Stela, Bokemark, Lena, Ronkainen, Kimmo, Amato, Mauro, Schminke, Ulf, Srinivasan, Sathanur R., Lind, Lars, Okazaki, Shuhei, Stehouwer, Coen D. A., Willeit, Peter, Polak, Joseph F., Steinmetz, Helmuth, Sander, Dirk, Poppert, Holger, Desvarieux, Moise, Ikram, M. Arfan, Johnsen, Stein Harald, Staub, Daniel, Sirtori, Cesare R., Igiseder, Bernhard, Beloqui, Oscar, Engstrom, Gunnar, Friera, Alfonso, Rozza, Francesco, Xie, Wuxiang, Parraga, Grace, Grigore, Liliana, Plichart, Matthieu, Blankenberg, Stefan, Su, Ta-Chen, Schmidt, Caroline, Tuomainen, Tomi-Pekka, Veglia, Fabrizio, Voelzke, Henry, Nijpels, Giel, Willeit, Johann, Sacco, Ralph L., Franco, Oscar H., Uthoff, Heiko, Hedblad, Bo, Suarez, Carmen, Izzo, Raffaele, Zhao, Dong, Wannarong, Thapat, Catapano, Alberico, Ducimetiere, Pierre, Espinola-Klein, Christine, Chien, Kuo-Liong, Price, Jackie F., Bergstrom, Goren, Kauhanen, Jussi, Tremoli, Elena, Doerr, Marcus, Berenson, Gerald, Kitagawa, Kazuo, Dekker, Jacqueline M., Kiechl, Stefan, Sitzer, Matthias, Bickel, Horst, Rundek, Tatjana, Hofman, Albert, Mathiesen, Ellisiv B., Castelnuovo, Samuela, Landecho, Manuel F., Rosvall, Maria, Gabriel, Rafael, de Luca, Nicola, Liu, Jing, Baldassarre, Damiano, Kavousi, Maryam, de Groot, Eric, Bots, Michiel L., Yanez, David N., and Thompson, Simon G.

Abstract

Aims: Carotid intima media thickness (CIMT) predicts cardiovascular (CVD) events, but the predictive value of CIMT change is debated. We assessed the relation between CIMT change and events in individuals at high cardiovascular risk. Methods and results: From 31 cohorts with two CIMT scans (total n = 89070) on average 3.6 years apart and clinical follow-up, subcohorts were drawn: (A) individuals with at least 3 cardiovascular risk factors without previous CVD events, (B) individuals with carotid plaques without previous CVD events, and (C) individuals with previous CVD events. Cox regression models were fit to estimate the hazard ratio (HR) of the combined endpoint (myocardial infarction, stroke or vascular death) per standard deviation (SD) of CIMT change, adjusted for CVD risk factors. These HRs were pooled across studies. In groups A, B and C we observed 3483, 2845 and 1165 endpoint events, respectively. Average common CIMT was 0.79mm (SD 0.16mm), and annual common CIMT change was 0.01mm (SD 0.07mm), both in group A. The pooled HR per SD of annual common CIMT change (0.02 to 0.43mm) was 0.99 (95% confidence interval: 0.95-1.02) in group A, 0.98 (0.93-1.04) in group B, and 0.95 (0.89-1.04) in group C. The HR per SD of common CIMT (average of the first and the second CIMT scan, 0.09 to 0.75mm) was 1.15 (1.07-1.23) in group A, 1.13 (1.05-1.22) in group B, and 1.12 (1.05-1.20) in group C. Conclusions: We confirm that common CIMT is associated with future CVD events in individuals at high risk. CIMT change does not relate to future event risk in high-risk individuals.

Published
2018
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12. Predictive value for cardiovascular events of common carotid intima media thickness and its rate of change in individuals at high cardiovascular risk - Results from the PROG-IMT collaboration

Author

Lorenz, Matthias W., Gao, Lu, Ziegelbauer, Kathrin, Norata, Giuseppe Danilo, Empana, Jean Philippe, Schmidtmann, Irene, Lin, Hung-Ju, McLachlan, Stela, Bokemark, Lena, Ronkainen, Kimmo, Amato, Mauro, Schminke, Ulf, Srinivasan, Sathanur R., Lind, Lars, Okazaki, Shuhei, Stehouwer, Coen D. A., Willeit, Peter, Polak, Joseph F., Steinmetz, Helmuth, Sander, Dirk, Poppert, Holger, Desvarieux, Moise, Ikram, M. Arfan, Johnsen, Stein Harald, Staub, Daniel, Sirtori, Cesare R., Igiseder, Bernhard, Beloqui, Oscar, Engstrom, Gunnar, Friera, Alfonso, Rozza, Francesco, Xie, Wuxiang, Parraga, Grace, Grigore, Liliana, Plichart, Matthieu, Blankenberg, Stefan, Su, Ta-Chen, Schmidt, Caroline, Tuomainen, Tomi-Pekka, Veglia, Fabrizio, Voelzke, Henry, Nijpels, Giel, Willeit, Johann, Sacco, Ralph L., Franco, Oscar H., Uthoff, Heiko, Hedblad, Bo, Suarez, Carmen, Izzo, Raffaele, Zhao, Dong, Wannarong, Thapat, Catapano, Alberico, Ducimetiere, Pierre, Espinola-Klein, Christine, Chien, Kuo-Liong, Price, Jackie F., Bergstrom, Goren, Kauhanen, Jussi, Tremoli, Elena, Doerr, Marcus, Berenson, Gerald, Kitagawa, Kazuo, Dekker, Jacqueline M., Kiechl, Stefan, Sitzer, Matthias, Bickel, Horst, Rundek, Tatjana, Hofman, Albert, Mathiesen, Ellisiv B., Castelnuovo, Samuela, Landecho, Manuel F., Rosvall, Maria, Gabriel, Rafael, de Luca, Nicola, Liu, Jing, Baldassarre, Damiano, Kavousi, Maryam, de Groot, Eric, Bots, Michiel L., Yanez, David N., Thompson, Simon G., Lorenz, Matthias W., Gao, Lu, Ziegelbauer, Kathrin, Norata, Giuseppe Danilo, Empana, Jean Philippe, Schmidtmann, Irene, Lin, Hung-Ju, McLachlan, Stela, Bokemark, Lena, Ronkainen, Kimmo, Amato, Mauro, Schminke, Ulf, Srinivasan, Sathanur R., Lind, Lars, Okazaki, Shuhei, Stehouwer, Coen D. A., Willeit, Peter, Polak, Joseph F., Steinmetz, Helmuth, Sander, Dirk, Poppert, Holger, Desvarieux, Moise, Ikram, M. Arfan, Johnsen, Stein Harald, Staub, Daniel, Sirtori, Cesare R., Igiseder, Bernhard, Beloqui, Oscar, Engstrom, Gunnar, Friera, Alfonso, Rozza, Francesco, Xie, Wuxiang, Parraga, Grace, Grigore, Liliana, Plichart, Matthieu, Blankenberg, Stefan, Su, Ta-Chen, Schmidt, Caroline, Tuomainen, Tomi-Pekka, Veglia, Fabrizio, Voelzke, Henry, Nijpels, Giel, Willeit, Johann, Sacco, Ralph L., Franco, Oscar H., Uthoff, Heiko, Hedblad, Bo, Suarez, Carmen, Izzo, Raffaele, Zhao, Dong, Wannarong, Thapat, Catapano, Alberico, Ducimetiere, Pierre, Espinola-Klein, Christine, Chien, Kuo-Liong, Price, Jackie F., Bergstrom, Goren, Kauhanen, Jussi, Tremoli, Elena, Doerr, Marcus, Berenson, Gerald, Kitagawa, Kazuo, Dekker, Jacqueline M., Kiechl, Stefan, Sitzer, Matthias, Bickel, Horst, Rundek, Tatjana, Hofman, Albert, Mathiesen, Ellisiv B., Castelnuovo, Samuela, Landecho, Manuel F., Rosvall, Maria, Gabriel, Rafael, de Luca, Nicola, Liu, Jing, Baldassarre, Damiano, Kavousi, Maryam, de Groot, Eric, Bots, Michiel L., Yanez, David N., and Thompson, Simon G.

Abstract

Aims: Carotid intima media thickness (CIMT) predicts cardiovascular (CVD) events, but the predictive value of CIMT change is debated. We assessed the relation between CIMT change and events in individuals at high cardiovascular risk. Methods and results: From 31 cohorts with two CIMT scans (total n = 89070) on average 3.6 years apart and clinical follow-up, subcohorts were drawn: (A) individuals with at least 3 cardiovascular risk factors without previous CVD events, (B) individuals with carotid plaques without previous CVD events, and (C) individuals with previous CVD events. Cox regression models were fit to estimate the hazard ratio (HR) of the combined endpoint (myocardial infarction, stroke or vascular death) per standard deviation (SD) of CIMT change, adjusted for CVD risk factors. These HRs were pooled across studies. In groups A, B and C we observed 3483, 2845 and 1165 endpoint events, respectively. Average common CIMT was 0.79mm (SD 0.16mm), and annual common CIMT change was 0.01mm (SD 0.07mm), both in group A. The pooled HR per SD of annual common CIMT change (0.02 to 0.43mm) was 0.99 (95% confidence interval: 0.95-1.02) in group A, 0.98 (0.93-1.04) in group B, and 0.95 (0.89-1.04) in group C. The HR per SD of common CIMT (average of the first and the second CIMT scan, 0.09 to 0.75mm) was 1.15 (1.07-1.23) in group A, 1.13 (1.05-1.22) in group B, and 1.12 (1.05-1.20) in group C. Conclusions: We confirm that common CIMT is associated with future CVD events in individuals at high risk. CIMT change does not relate to future event risk in high-risk individuals.

Published
2018
Full Text
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13. Predictive value for cardiovascular events of common carotid intima media thickness and its rate of change in individuals at high cardiovascular risk - Results from the PROG-IMT collaboration

Author

Lorenz, Matthias W., Gao, Lu, Ziegelbauer, Kathrin, Norata, Giuseppe Danilo, Empana, Jean Philippe, Schmidtmann, Irene, Lin, Hung-Ju, McLachlan, Stela, Bokemark, Lena, Ronkainen, Kimmo, Amato, Mauro, Schminke, Ulf, Srinivasan, Sathanur R., Lind, Lars, Okazaki, Shuhei, Stehouwer, Coen D. A., Willeit, Peter, Polak, Joseph F., Steinmetz, Helmuth, Sander, Dirk, Poppert, Holger, Desvarieux, Moise, Ikram, M. Arfan, Johnsen, Stein Harald, Staub, Daniel, Sirtori, Cesare R., Igiseder, Bernhard, Beloqui, Oscar, Engstrom, Gunnar, Friera, Alfonso, Rozza, Francesco, Xie, Wuxiang, Parraga, Grace, Grigore, Liliana, Plichart, Matthieu, Blankenberg, Stefan, Su, Ta-Chen, Schmidt, Caroline, Tuomainen, Tomi-Pekka, Veglia, Fabrizio, Voelzke, Henry, Nijpels, Giel, Willeit, Johann, Sacco, Ralph L., Franco, Oscar H., Uthoff, Heiko, Hedblad, Bo, Suarez, Carmen, Izzo, Raffaele, Zhao, Dong, Wannarong, Thapat, Catapano, Alberico, Ducimetiere, Pierre, Espinola-Klein, Christine, Chien, Kuo-Liong, Price, Jackie F., Bergstrom, Goren, Kauhanen, Jussi, Tremoli, Elena, Doerr, Marcus, Berenson, Gerald, Kitagawa, Kazuo, Dekker, Jacqueline M., Kiechl, Stefan, Sitzer, Matthias, Bickel, Horst, Rundek, Tatjana, Hofman, Albert, Mathiesen, Ellisiv B., Castelnuovo, Samuela, Landecho, Manuel F., Rosvall, Maria, Gabriel, Rafael, de Luca, Nicola, Liu, Jing, Baldassarre, Damiano, Kavousi, Maryam, de Groot, Eric, Bots, Michiel L., Yanez, David N., Thompson, Simon G., Lorenz, Matthias W., Gao, Lu, Ziegelbauer, Kathrin, Norata, Giuseppe Danilo, Empana, Jean Philippe, Schmidtmann, Irene, Lin, Hung-Ju, McLachlan, Stela, Bokemark, Lena, Ronkainen, Kimmo, Amato, Mauro, Schminke, Ulf, Srinivasan, Sathanur R., Lind, Lars, Okazaki, Shuhei, Stehouwer, Coen D. A., Willeit, Peter, Polak, Joseph F., Steinmetz, Helmuth, Sander, Dirk, Poppert, Holger, Desvarieux, Moise, Ikram, M. Arfan, Johnsen, Stein Harald, Staub, Daniel, Sirtori, Cesare R., Igiseder, Bernhard, Beloqui, Oscar, Engstrom, Gunnar, Friera, Alfonso, Rozza, Francesco, Xie, Wuxiang, Parraga, Grace, Grigore, Liliana, Plichart, Matthieu, Blankenberg, Stefan, Su, Ta-Chen, Schmidt, Caroline, Tuomainen, Tomi-Pekka, Veglia, Fabrizio, Voelzke, Henry, Nijpels, Giel, Willeit, Johann, Sacco, Ralph L., Franco, Oscar H., Uthoff, Heiko, Hedblad, Bo, Suarez, Carmen, Izzo, Raffaele, Zhao, Dong, Wannarong, Thapat, Catapano, Alberico, Ducimetiere, Pierre, Espinola-Klein, Christine, Chien, Kuo-Liong, Price, Jackie F., Bergstrom, Goren, Kauhanen, Jussi, Tremoli, Elena, Doerr, Marcus, Berenson, Gerald, Kitagawa, Kazuo, Dekker, Jacqueline M., Kiechl, Stefan, Sitzer, Matthias, Bickel, Horst, Rundek, Tatjana, Hofman, Albert, Mathiesen, Ellisiv B., Castelnuovo, Samuela, Landecho, Manuel F., Rosvall, Maria, Gabriel, Rafael, de Luca, Nicola, Liu, Jing, Baldassarre, Damiano, Kavousi, Maryam, de Groot, Eric, Bots, Michiel L., Yanez, David N., and Thompson, Simon G.

Abstract

Aims: Carotid intima media thickness (CIMT) predicts cardiovascular (CVD) events, but the predictive value of CIMT change is debated. We assessed the relation between CIMT change and events in individuals at high cardiovascular risk. Methods and results: From 31 cohorts with two CIMT scans (total n = 89070) on average 3.6 years apart and clinical follow-up, subcohorts were drawn: (A) individuals with at least 3 cardiovascular risk factors without previous CVD events, (B) individuals with carotid plaques without previous CVD events, and (C) individuals with previous CVD events. Cox regression models were fit to estimate the hazard ratio (HR) of the combined endpoint (myocardial infarction, stroke or vascular death) per standard deviation (SD) of CIMT change, adjusted for CVD risk factors. These HRs were pooled across studies. In groups A, B and C we observed 3483, 2845 and 1165 endpoint events, respectively. Average common CIMT was 0.79mm (SD 0.16mm), and annual common CIMT change was 0.01mm (SD 0.07mm), both in group A. The pooled HR per SD of annual common CIMT change (0.02 to 0.43mm) was 0.99 (95% confidence interval: 0.95-1.02) in group A, 0.98 (0.93-1.04) in group B, and 0.95 (0.89-1.04) in group C. The HR per SD of common CIMT (average of the first and the second CIMT scan, 0.09 to 0.75mm) was 1.15 (1.07-1.23) in group A, 1.13 (1.05-1.22) in group B, and 1.12 (1.05-1.20) in group C. Conclusions: We confirm that common CIMT is associated with future CVD events in individuals at high risk. CIMT change does not relate to future event risk in high-risk individuals.

Published
2018
Full Text
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14. Predictive value for cardiovascular events of common carotid intima media thickness and its rate of change in individuals at high cardiovascular risk - Results from the PROG-IMT collaboration

Author

Lorenz, Matthias W., Gao, Lu, Ziegelbauer, Kathrin, Norata, Giuseppe Danilo, Empana, Jean Philippe, Schmidtmann, Irene, Lin, Hung-Ju, McLachlan, Stela, Bokemark, Lena, Ronkainen, Kimmo, Amato, Mauro, Schminke, Ulf, Srinivasan, Sathanur R., Lind, Lars, Okazaki, Shuhei, Stehouwer, Coen D. A., Willeit, Peter, Polak, Joseph F., Steinmetz, Helmuth, Sander, Dirk, Poppert, Holger, Desvarieux, Moise, Ikram, M. Arfan, Johnsen, Stein Harald, Staub, Daniel, Sirtori, Cesare R., Igiseder, Bernhard, Beloqui, Oscar, Engstrom, Gunnar, Friera, Alfonso, Rozza, Francesco, Xie, Wuxiang, Parraga, Grace, Grigore, Liliana, Plichart, Matthieu, Blankenberg, Stefan, Su, Ta-Chen, Schmidt, Caroline, Tuomainen, Tomi-Pekka, Veglia, Fabrizio, Voelzke, Henry, Nijpels, Giel, Willeit, Johann, Sacco, Ralph L., Franco, Oscar H., Uthoff, Heiko, Hedblad, Bo, Suarez, Carmen, Izzo, Raffaele, Zhao, Dong, Wannarong, Thapat, Catapano, Alberico, Ducimetiere, Pierre, Espinola-Klein, Christine, Chien, Kuo-Liong, Price, Jackie F., Bergstrom, Goren, Kauhanen, Jussi, Tremoli, Elena, Doerr, Marcus, Berenson, Gerald, Kitagawa, Kazuo, Dekker, Jacqueline M., Kiechl, Stefan, Sitzer, Matthias, Bickel, Horst, Rundek, Tatjana, Hofman, Albert, Mathiesen, Ellisiv B., Castelnuovo, Samuela, Landecho, Manuel F., Rosvall, Maria, Gabriel, Rafael, de Luca, Nicola, Liu, Jing, Baldassarre, Damiano, Kavousi, Maryam, de Groot, Eric, Bots, Michiel L., Yanez, David N., Thompson, Simon G., Lorenz, Matthias W., Gao, Lu, Ziegelbauer, Kathrin, Norata, Giuseppe Danilo, Empana, Jean Philippe, Schmidtmann, Irene, Lin, Hung-Ju, McLachlan, Stela, Bokemark, Lena, Ronkainen, Kimmo, Amato, Mauro, Schminke, Ulf, Srinivasan, Sathanur R., Lind, Lars, Okazaki, Shuhei, Stehouwer, Coen D. A., Willeit, Peter, Polak, Joseph F., Steinmetz, Helmuth, Sander, Dirk, Poppert, Holger, Desvarieux, Moise, Ikram, M. Arfan, Johnsen, Stein Harald, Staub, Daniel, Sirtori, Cesare R., Igiseder, Bernhard, Beloqui, Oscar, Engstrom, Gunnar, Friera, Alfonso, Rozza, Francesco, Xie, Wuxiang, Parraga, Grace, Grigore, Liliana, Plichart, Matthieu, Blankenberg, Stefan, Su, Ta-Chen, Schmidt, Caroline, Tuomainen, Tomi-Pekka, Veglia, Fabrizio, Voelzke, Henry, Nijpels, Giel, Willeit, Johann, Sacco, Ralph L., Franco, Oscar H., Uthoff, Heiko, Hedblad, Bo, Suarez, Carmen, Izzo, Raffaele, Zhao, Dong, Wannarong, Thapat, Catapano, Alberico, Ducimetiere, Pierre, Espinola-Klein, Christine, Chien, Kuo-Liong, Price, Jackie F., Bergstrom, Goren, Kauhanen, Jussi, Tremoli, Elena, Doerr, Marcus, Berenson, Gerald, Kitagawa, Kazuo, Dekker, Jacqueline M., Kiechl, Stefan, Sitzer, Matthias, Bickel, Horst, Rundek, Tatjana, Hofman, Albert, Mathiesen, Ellisiv B., Castelnuovo, Samuela, Landecho, Manuel F., Rosvall, Maria, Gabriel, Rafael, de Luca, Nicola, Liu, Jing, Baldassarre, Damiano, Kavousi, Maryam, de Groot, Eric, Bots, Michiel L., Yanez, David N., and Thompson, Simon G.

Abstract

Aims: Carotid intima media thickness (CIMT) predicts cardiovascular (CVD) events, but the predictive value of CIMT change is debated. We assessed the relation between CIMT change and events in individuals at high cardiovascular risk. Methods and results: From 31 cohorts with two CIMT scans (total n = 89070) on average 3.6 years apart and clinical follow-up, subcohorts were drawn: (A) individuals with at least 3 cardiovascular risk factors without previous CVD events, (B) individuals with carotid plaques without previous CVD events, and (C) individuals with previous CVD events. Cox regression models were fit to estimate the hazard ratio (HR) of the combined endpoint (myocardial infarction, stroke or vascular death) per standard deviation (SD) of CIMT change, adjusted for CVD risk factors. These HRs were pooled across studies. In groups A, B and C we observed 3483, 2845 and 1165 endpoint events, respectively. Average common CIMT was 0.79mm (SD 0.16mm), and annual common CIMT change was 0.01mm (SD 0.07mm), both in group A. The pooled HR per SD of annual common CIMT change (0.02 to 0.43mm) was 0.99 (95% confidence interval: 0.95-1.02) in group A, 0.98 (0.93-1.04) in group B, and 0.95 (0.89-1.04) in group C. The HR per SD of common CIMT (average of the first and the second CIMT scan, 0.09 to 0.75mm) was 1.15 (1.07-1.23) in group A, 1.13 (1.05-1.22) in group B, and 1.12 (1.05-1.20) in group C. Conclusions: We confirm that common CIMT is associated with future CVD events in individuals at high risk. CIMT change does not relate to future event risk in high-risk individuals.

Published
2018
Full Text
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15. Predictive value for cardiovascular events of common carotid intima media thickness and its rate of change in individuals at high cardiovascular risk - Results from the PROG-IMT collaboration

Author

Lorenz, Matthias W., Gao, Lu, Ziegelbauer, Kathrin, Norata, Giuseppe Danilo, Empana, Jean Philippe, Schmidtmann, Irene, Lin, Hung-Ju, McLachlan, Stela, Bokemark, Lena, Ronkainen, Kimmo, Amato, Mauro, Schminke, Ulf, Srinivasan, Sathanur R., Lind, Lars, Okazaki, Shuhei, Stehouwer, Coen D. A., Willeit, Peter, Polak, Joseph F., Steinmetz, Helmuth, Sander, Dirk, Poppert, Holger, Desvarieux, Moise, Ikram, M. Arfan, Johnsen, Stein Harald, Staub, Daniel, Sirtori, Cesare R., Igiseder, Bernhard, Beloqui, Oscar, Engstrom, Gunnar, Friera, Alfonso, Rozza, Francesco, Xie, Wuxiang, Parraga, Grace, Grigore, Liliana, Plichart, Matthieu, Blankenberg, Stefan, Su, Ta-Chen, Schmidt, Caroline, Tuomainen, Tomi-Pekka, Veglia, Fabrizio, Voelzke, Henry, Nijpels, Giel, Willeit, Johann, Sacco, Ralph L., Franco, Oscar H., Uthoff, Heiko, Hedblad, Bo, Suarez, Carmen, Izzo, Raffaele, Zhao, Dong, Wannarong, Thapat, Catapano, Alberico, Ducimetiere, Pierre, Espinola-Klein, Christine, Chien, Kuo-Liong, Price, Jackie F., Bergstrom, Goren, Kauhanen, Jussi, Tremoli, Elena, Doerr, Marcus, Berenson, Gerald, Kitagawa, Kazuo, Dekker, Jacqueline M., Kiechl, Stefan, Sitzer, Matthias, Bickel, Horst, Rundek, Tatjana, Hofman, Albert, Mathiesen, Ellisiv B., Castelnuovo, Samuela, Landecho, Manuel F., Rosvall, Maria, Gabriel, Rafael, de Luca, Nicola, Liu, Jing, Baldassarre, Damiano, Kavousi, Maryam, de Groot, Eric, Bots, Michiel L., Yanez, David N., Thompson, Simon G., Lorenz, Matthias W., Gao, Lu, Ziegelbauer, Kathrin, Norata, Giuseppe Danilo, Empana, Jean Philippe, Schmidtmann, Irene, Lin, Hung-Ju, McLachlan, Stela, Bokemark, Lena, Ronkainen, Kimmo, Amato, Mauro, Schminke, Ulf, Srinivasan, Sathanur R., Lind, Lars, Okazaki, Shuhei, Stehouwer, Coen D. A., Willeit, Peter, Polak, Joseph F., Steinmetz, Helmuth, Sander, Dirk, Poppert, Holger, Desvarieux, Moise, Ikram, M. Arfan, Johnsen, Stein Harald, Staub, Daniel, Sirtori, Cesare R., Igiseder, Bernhard, Beloqui, Oscar, Engstrom, Gunnar, Friera, Alfonso, Rozza, Francesco, Xie, Wuxiang, Parraga, Grace, Grigore, Liliana, Plichart, Matthieu, Blankenberg, Stefan, Su, Ta-Chen, Schmidt, Caroline, Tuomainen, Tomi-Pekka, Veglia, Fabrizio, Voelzke, Henry, Nijpels, Giel, Willeit, Johann, Sacco, Ralph L., Franco, Oscar H., Uthoff, Heiko, Hedblad, Bo, Suarez, Carmen, Izzo, Raffaele, Zhao, Dong, Wannarong, Thapat, Catapano, Alberico, Ducimetiere, Pierre, Espinola-Klein, Christine, Chien, Kuo-Liong, Price, Jackie F., Bergstrom, Goren, Kauhanen, Jussi, Tremoli, Elena, Doerr, Marcus, Berenson, Gerald, Kitagawa, Kazuo, Dekker, Jacqueline M., Kiechl, Stefan, Sitzer, Matthias, Bickel, Horst, Rundek, Tatjana, Hofman, Albert, Mathiesen, Ellisiv B., Castelnuovo, Samuela, Landecho, Manuel F., Rosvall, Maria, Gabriel, Rafael, de Luca, Nicola, Liu, Jing, Baldassarre, Damiano, Kavousi, Maryam, de Groot, Eric, Bots, Michiel L., Yanez, David N., and Thompson, Simon G.

Abstract

Aims: Carotid intima media thickness (CIMT) predicts cardiovascular (CVD) events, but the predictive value of CIMT change is debated. We assessed the relation between CIMT change and events in individuals at high cardiovascular risk. Methods and results: From 31 cohorts with two CIMT scans (total n = 89070) on average 3.6 years apart and clinical follow-up, subcohorts were drawn: (A) individuals with at least 3 cardiovascular risk factors without previous CVD events, (B) individuals with carotid plaques without previous CVD events, and (C) individuals with previous CVD events. Cox regression models were fit to estimate the hazard ratio (HR) of the combined endpoint (myocardial infarction, stroke or vascular death) per standard deviation (SD) of CIMT change, adjusted for CVD risk factors. These HRs were pooled across studies. In groups A, B and C we observed 3483, 2845 and 1165 endpoint events, respectively. Average common CIMT was 0.79mm (SD 0.16mm), and annual common CIMT change was 0.01mm (SD 0.07mm), both in group A. The pooled HR per SD of annual common CIMT change (0.02 to 0.43mm) was 0.99 (95% confidence interval: 0.95-1.02) in group A, 0.98 (0.93-1.04) in group B, and 0.95 (0.89-1.04) in group C. The HR per SD of common CIMT (average of the first and the second CIMT scan, 0.09 to 0.75mm) was 1.15 (1.07-1.23) in group A, 1.13 (1.05-1.22) in group B, and 1.12 (1.05-1.20) in group C. Conclusions: We confirm that common CIMT is associated with future CVD events in individuals at high risk. CIMT change does not relate to future event risk in high-risk individuals.

Published
2018
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16. Normative values for carotid intima media thickness and its progression : Are they transferrable outside of their cohort of origin?

Author

Liao, Ximing, Norata, Giuseppe D., Polak, Joseph F., Stehouwer, Coen D. A., Catapano, Alberico, Rundek, Tatjana, Ezhov, Marat, Sander, Dirk, Thompson, Simon G., Lorenz, Matthias W., Balakhonova, Tatyana, Safarova, Maya, Grigore, Liliana, Empana, Jean-Philippe, Lin, Hung-Ju, McLachlan, Stela, Bokemark, Lena, Ronkainen, Kimmo, Schminke, Ulf, Lind, Lars, Willeit, Peter, Yanez, David N., Steinmetz, Helmuth, Poppert, Holger, Desvarieux, Moise, Ikram, M. Arfan, Johnsen, Stein Harald, Iglseder, Bernhard, Friera, Alfonsa, Xie, Wuxiang, Plichart, Matthieu, Su, Ta-Chen, Srinivasan, Sathanur R., Schmidt, Caroline, Tuomainen, Tomi-Pekka, Volzke, Henry, Nijpels, Giel, Willeit, Johann, Franco, Oscar H., Suarez, Carmen, Zhao, Dong, Ducimetiere, Pierre, Chien, Kuo-Liong, Robertson, Christine, Bergstrom, Goran, Kauhanen, Jussi, Dorr, Marcus, Dekker, Jaqueline M., Kiechl, Stefan, Sitzer, Matthias, Bickel, Horst, Sacco, Ralph L., Hofman, Albert, Mathiesen, Ellisiv B., Gabriel, Rafael, Liu, Jing, Berenson, Gerald, Kavousi, Maryam, Price, Jackie F., Liao, Ximing, Norata, Giuseppe D., Polak, Joseph F., Stehouwer, Coen D. A., Catapano, Alberico, Rundek, Tatjana, Ezhov, Marat, Sander, Dirk, Thompson, Simon G., Lorenz, Matthias W., Balakhonova, Tatyana, Safarova, Maya, Grigore, Liliana, Empana, Jean-Philippe, Lin, Hung-Ju, McLachlan, Stela, Bokemark, Lena, Ronkainen, Kimmo, Schminke, Ulf, Lind, Lars, Willeit, Peter, Yanez, David N., Steinmetz, Helmuth, Poppert, Holger, Desvarieux, Moise, Ikram, M. Arfan, Johnsen, Stein Harald, Iglseder, Bernhard, Friera, Alfonsa, Xie, Wuxiang, Plichart, Matthieu, Su, Ta-Chen, Srinivasan, Sathanur R., Schmidt, Caroline, Tuomainen, Tomi-Pekka, Volzke, Henry, Nijpels, Giel, Willeit, Johann, Franco, Oscar H., Suarez, Carmen, Zhao, Dong, Ducimetiere, Pierre, Chien, Kuo-Liong, Robertson, Christine, Bergstrom, Goran, Kauhanen, Jussi, Dorr, Marcus, Dekker, Jaqueline M., Kiechl, Stefan, Sitzer, Matthias, Bickel, Horst, Sacco, Ralph L., Hofman, Albert, Mathiesen, Ellisiv B., Gabriel, Rafael, Liu, Jing, Berenson, Gerald, Kavousi, Maryam, and Price, Jackie F.

Abstract

Background The clinical use of carotid intima media thickness (cIMT) requires normal values, which may be subject to variation of geographical factors, ethnicity or measurement details. The influence of these factors has rarely been studied. The aim of this study was to determine whether normative cIMT values and their association with event risk are generalizable across populations. Design Meta-analysis of individual participant data. Method From 22 general population cohorts from Europe, North America and Asia we selected subjects free of cardiovascular disease. Percentiles of cIMT and cIMT progression were assessed separately for every cohort. Cox proportional hazards models for vascular events were used to estimate hazard ratios for cIMT in each cohort. The estimates were pooled across Europe, North America and Asia, with random effects meta-analysis. The influence of geography, ethnicity and ultrasound protocols on cIMT values and on the hazard ratios was examined by meta-regression. Results Geographical factors, ethnicity and the ultrasound protocol had influence neither on the percentiles of cIMT and its progression, nor on the hazard ratios of cIMT for vascular events. Heterogeneity for percentiles of cIMT and cIMT progression was too large to create meaningful normative values. Conclusions The distribution of cIMT values is too heterogeneous to define universal or regional population reference values. CIMT values vary widely between different studies regardless of ethnicity, geographic location and ultrasound protocol. Prediction of vascular events with cIMT values was more consistent across all cohorts, ethnicities and regions.

Published
2016
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