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2 results on '"Bertschi, Daniela A'

1. Long-Term Mortality after New-Onset Atrial Fibrillation in COVID-19

Author

Jurisic, Stjepan, Komminoth, Mathis; https://orcid.org/0000-0002-0024-6284, Todorov, Atanas, Bertschi, Daniela A; https://orcid.org/0009-0009-5983-1160, Jurisic, Martin, Vranjic, Ivica; https://orcid.org/0000-0002-2442-636X, Wiggli, Benedikt, Schmid, Hansruedi, Gebhard, Catherine; https://orcid.org/0000-0001-7240-5822, Gebhard, Caroline E; https://orcid.org/0000-0003-4975-2679, Heidecker, Bettina; https://orcid.org/0000-0002-3811-7920, Beer, Jürg-Hans; https://orcid.org/0000-0002-7199-0406, Patriki, Dimitri; https://orcid.org/0000-0001-6364-0927, Jurisic, Stjepan, Komminoth, Mathis; https://orcid.org/0000-0002-0024-6284, Todorov, Atanas, Bertschi, Daniela A; https://orcid.org/0009-0009-5983-1160, Jurisic, Martin, Vranjic, Ivica; https://orcid.org/0000-0002-2442-636X, Wiggli, Benedikt, Schmid, Hansruedi, Gebhard, Catherine; https://orcid.org/0000-0001-7240-5822, Gebhard, Caroline E; https://orcid.org/0000-0003-4975-2679, Heidecker, Bettina; https://orcid.org/0000-0002-3811-7920, Beer, Jürg-Hans; https://orcid.org/0000-0002-7199-0406, and Patriki, Dimitri; https://orcid.org/0000-0001-6364-0927

Abstract

Background: Atrial fibrillation (AF) has been described as a common cardiovascular manifestation in patients suffering from coronavirus disease 2019 (COVID-19) and has been suggested to be a potential risk factor for a poor clinical outcome. Methods: In this observational study, all patients hospitalized due to COVID-19 in 2020 in the Cantonal Hospital of Baden were included. We assessed clinical characteristics, in-hospital outcomes as well as long-term outcomes with a mean follow-up time of 278 (±90) days. Results: Amongst 646 patients diagnosed with COVID-19 (59% male, median age: 70 (IQR: 59-80)) in 2020, a total of 177 (27.4%) patients were transferred to the intermediate/intensive care unit (IMC/ICU), and 76 (11.8%) were invasively ventilated during their hospitalization. Ninety patients (13.9%) died. A total of 116 patients (18%) showed AF on admission of which 34 (29%) had new-onset AF. Patients with COVID-19 and newly diagnosed AF were more likely to require invasive ventilation (OR: 3.5; p = 0.01) but did not encounter an increased in-hospital mortality. Moreover, AF neither increased long-term mortality nor the number of rehospitalizations during follow-up after adjusting for confounders. Conclusions: In patients suffering from COVID-19, the new-onset of AF on admission was associated with an increased risk of invasive ventilation and transfer to the IMC/ICU but did not affect in-hospital or long-term mortality.

Published
2023

2. Omega-3 Fatty Acids and Markers of Thrombosis in Patients with Atrial Fibrillation.

Author

Reiner MF, Bertschi DA, Werlen L, Wiencierz A, Aeschbacher S, Lee P, Rodondi N, Moutzouri E, Bonati L, Reichlin T, Moschovitis G, Rutishauser J, Kühne M, Osswald S, Conen D, and Beer JH

Subjects
Humans, Cohort Studies, Cross-Sectional Studies, Fibrinolytic Agents, Docosahexaenoic Acids, Eicosapentaenoic Acid, Atrial Fibrillation complications, Atrial Fibrillation drug therapy, Fatty Acids, Omega-3, Thrombosis
Abstract

Omega-3 fatty acids ( n -3 FAs) are associated with a lower risk of ischemic stroke in patients with atrial fibrillation (AF). Antithrombotic mechanisms may in part explain this observation. Therefore, we examined the association of n -3 FAs with D-dimer and beta-thromboglobulin (BTG), markers for activated coagulation and platelets, respectively. The n -3 FAs eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), docosapentaenoic acid (DPA) and alpha-linolenic acid (ALA) were determined via gas chromatography in the whole blood of 2373 patients with AF from the Swiss Atrial Fibrillation cohort study (ClinicalTrials.gov Identifier: NCT02105844). In a cross-sectional analysis, we examined the association of total n -3 FAs (EPA + DHA + DPA + ALA) and the association of individual fatty acids with D-dimer in patients with detectable D-dimer values ( n = 1096) as well as with BTG ( n = 2371) using multiple linear regression models adjusted for confounders. Median D-dimer and BTG levels were 0.340 ug/mL and 448 ng/mL, respectively. Higher total n -3 FAs correlated with lower D-dimer levels (coefficient 0.94, 95% confidence interval (Cl) 0.90-0.98, p = 0.004) and lower BTG levels (coefficient 0.97, Cl 0.95-0.99, p = 0.003). Likewise, the individual n -3 FAs EPA, DHA, DPA and ALA showed an inverse association with D-dimer. Higher levels of DHA, DPA and ALA correlated with lower BTG levels, whereas EPA showed a positive association with BTG. In patients with AF, higher levels of n -3 FAs were associated with lower levels of D-dimer and BTG, markers for activated coagulation and platelets, respectively. These findings suggest that n-3 FAs may exert antithrombotic properties in patients with AF.

Published
2024
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