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In recent years, the research and development of high-speed trains has advanced rapidly. The main development trends of high-speed trains are higher speeds, lower energy consumption, higher safety, and better environmental protection. The realization of a lightweight high-speed car body is one of the key features in the development trend of high-speed trains. Firstly, the basic dimensions of the car body’s geometric model are determined according to the external dimensions of the body of a CRH EMU, and the specific topology optimization design domain is selected to establish the finite element analysis model; secondly, the strength and modal analyses of the topology optimization design domain are carried out to check the accuracy of the design domain and provide a comparative analysis for subsequent design. Then, the variables, constraints, and objective functions of the topology optimization design are determined to establish the mathematical model of topology optimization, and the design domain is calculated for topology optimization under single and multiple conditions, respectively. Finally, based on the topology optimization calculation results, truss-type reconstruction modeling is carried out for the car body’s side walls, roof, underframe, end walls, and other parts. Compared with the conventional EMU body structure, the weight of the reconstructed body structure is reduced by about 18%. The results of the finite element analysis of the reconstructed car-body structure prove the reliability and safety of the structure, indicating that the reconstructed car-body scheme meets the corresponding performance indicators.

Precise characterization of biomolecular information such as molecular structures or intermolecular interactions provides essential mechanistic insights into the understanding of biochemical processes. As the resolution of imaging-based measurement techniques improves, so does the quantity of molecular information obtained using these methodologies. DNA (deoxyribonucleic acid) molecule have been used to build a variety of structures and dynamic devices on the nanoscale over the past 20 years, which has provided an accessible platform to manipulate molecules and resolve molecular information with unprecedented precision. In this review, we summarize recent progress related to obtaining precise molecular information using DNA nanotechnology. After a brief introduction to the development and features of structural and dynamic DNA nanotechnology, we outline some of the promising applications of DNA nanotechnology in structural biochemistry and in molecular biophysics. In particular, we highlight the use of DNA nanotechnology in determination of protein structures, protein–protein interactions, and molecular force.