Search

Oxidation–reduction post-translational modifications (redox-PTMs) are chemical alterations to amino acids of proteins. Redox-PTMs participate in the regulation of protein conformation, localization and function, acting as signalling effectors that impact many essential biochemical processes in the cells. Crucially, the dysregulation of redox-PTMs of proteins has been implicated in the pathophysiology of numerous human diseases, including neurodegenerative diseases such as Alzheimer’s disease and Parkinson’s disease. This review aims to highlight the current gaps in knowledge in the field of redox-PTMs biology and to explore new methodological advances in proteomics and computational modelling that will pave the way for a better understanding of the role and therapeutic potential of redox-PTMs of proteins in neurodegenerative diseases. Here, we summarize the main types of redox-PTMs of proteins while providing examples of their occurrence in neurodegenerative diseases and an overview of the state-of-the-art methods used for their detection. We explore the potential of novel computational modelling approaches as essential tools to obtain insights into the precise role of redox-PTMs in regulating protein structure and function. We also discuss the complex crosstalk between various PTMs that occur in living cells. Finally, we argue that redox-PTMs of proteins could be used in the future as diagnosis and prognosis biomarkers for neurodegenerative diseases.

The integration of distributed generation (DG) into a power distribution network allows the establishment of a microgrid (MG) system when the main grid experiences a malfunction or is undergoing maintenance. In this case, the power-generating capacity of distributed generators may be less than the load demand. This study presents a strategy for the effective utilization of deployed active and reactive power sources under power mismatch conditions in the islanded distribution networks. Initially, the DGs’ and capacitors’ optimal placement and capacity were identified using the Jaya algorithm (JA) with the aim to reduce power losses in the grid-connected mode. Later, the DG and capacitor combination’s optimal power factor was determined to withstand the islanded distribution network’s highest possible power demand in the event of a power mismatch. To assess the optimal value of the DG–capacitor pair’s operating power factor (pfsource) for the islanded operation, an analytical approach has been proposed that determines the best trade-off between power losses and the under-utilization of accessible generation. The test results on 33-bus and 69-bus IEEE distribution networks demonstrate that holding the islanded network’s load power factor (pfload) equal to pfsource during the power imbalance conditions allows the installed distributed sources to effectively operate at full capacity. As expected, the proposed strategy will assist the utility companies in designing efficient energy management or load shedding schemes to effectively cope with the power mismatch conditions.

This paper reviews the optimization strategies for the optimal simultaneous allocation of distributed generation (DG) and shunts capacitor banks (SCBs) in electrical distribution networks. These optimization strategies aim to determine the optimal size, location, and combination of DGs and SCBs to constitute a techno-economic system while satisfying the constraints and energy demand of the load. The optimization strategies explicitly reviewed include the problem formulations, optimization techniques, restrictions posed for optimization problems, decision variables, and network operating modes typically assumed while allocating the DGs and SCBs. In addition, there is an attempt to highlight the limitations of the existing literature and future research directions. This study undertakes a comprehensive review of the literature that systematically considers the simultaneous application of DGs and SCBs to advance the existing literature, which lacks such a review. Expectedly, this review will serve as a principle platform for researchers intending to explore the subject area for further improvement.

Due to the lack of inertia and uncertainty in the selection of optimal Proportional Integral (PI) controller gains, the voltage and frequency variations are higher in the islanded mode of the operation of a Microgrid (MG) compared to the grid-connected mode. This study, as such, develops an optimal control strategy for the voltage and frequency regulation of Photovoltaic (PV) based MG systems operating in islanding mode using Grasshopper Optimization Algorithm (GOA). The intelligence of the GOA is utilized to optimize the PI controller parameters. This ensures an enhanced dynamic response and power quality of the studied MG system during Distributed Generators (DG) insertion and load change conditions. A droop control is also employed within the control architecture, alongside the voltage and current control loops, as a power-sharing controller. In order to validate the performance of the proposed control architecture, its effectiveness in regulating MG voltage, frequency, and power quality is compared with the precedent Artificial Intelligence (AI) based control architectures for the same control objectives. The effectiveness of the proposed GOA based parameter selection method is also validated by analyzing its performance with respect to the improved transient response and power quality of the studied MG system in comparison with that of the Particle Swarm Optimization (PSO) and Whales Optimization Algorithm (WOA) based parameter selection methods. The simulation results establish that the GOA provides a faster and better solution than PSO and WOA which resulted in a minimum voltage and frequency overshoot with minimum output current and Total Harmonic Distortion (THD).