Search

Your search keyword '"Zheng, Haixue"' showing total 18 results
Start Over Author "Zheng, Haixue" Publisher mdpi ag
18 results on '"Zheng, Haixue"'

2. The Accumulation of Phenyllactic Acid Impairs Host Glutamine Metabolism and Inhibits African Swine Fever Virus Replication: A Novel Target for the Development of Anti-ASFV Drugs

Author

Dai, Junfei, primary, Ma, Xusheng, additional, Wubshet, Ashenafi Kiros, additional, Li, Qian, additional, Shang, Xiaofen, additional, Luo, Zhikuan, additional, Liu, Jianan, additional, Li, Zhiyu, additional, Li, Mingxia, additional, Song, Yujie, additional, Guo, Lijun, additional, Zhang, Jie, additional, and Zheng, Haixue, additional

Published
2024
Full Text
View/download PDF

5. DDX20: A Multifunctional Complex Protein

Author

He, Lu, primary, Yang, Jinke, additional, Hao, Yu, additional, Yang, Xing, additional, Shi, Xijuan, additional, Zhang, Dajun, additional, Zhao, Dengshuai, additional, Yan, Wenqian, additional, Bie, Xintian, additional, Chen, Lingling, additional, Chen, Guohui, additional, Zhao, Siyue, additional, Liu, Xiangtao, additional, Zheng, Haixue, additional, and Zhang, Keshan, additional

Published
2023
Full Text
View/download PDF

11. Evaluation of Antibody Response in Sows after Vaccination with Senecavirus A Vaccine and the Effect of Maternal Antibody Transfer on Antibody Dynamics in Offspring

Author

Yang, Fan, primary, Zhu, Zixiang, additional, Liu, Huanan, additional, Cao, Weijun, additional, Zhang, Wei, additional, Wei, Ting, additional, Zheng, Min, additional, Zhang, Keshan, additional, Tian, Hong, additional, Zeng, Qiaoying, additional, Cai, Xuepeng, additional, and Zheng, Haixue, additional

Published
2021
Full Text
View/download PDF

12. Construction, Identification and Analysis of the Interaction Network of African Swine Fever Virus MGF360-9L with Host Proteins

Author

Yang, Bo, primary, Zhang, Dajun, additional, Shi, Xijuan, additional, Shen, Chaochao, additional, Hao, Yu, additional, Zhang, Ting, additional, Yang, Jinke, additional, Yuan, Xingguo, additional, Chen, Xuehui, additional, Zhao, Dengshuai, additional, Cui, Huimei, additional, Li, Dan, additional, Zhu, Zixiang, additional, Tian, Hong, additional, Yang, Fan, additional, Zheng, Haixue, additional, Zhang, Keshan, additional, and Liu, Xiangtao, additional

Published
2021
Full Text
View/download PDF

13. Molecular Mechanisms of Immune Escape for Foot-and-Mouth Disease Virus

Author

Yang, Bo, primary, Zhang, Xiaohui, additional, Zhang, Dajun, additional, Hou, Jing, additional, Xu, GuoWei, additional, Sheng, Chaochao, additional, Choudhury, Sk Mohiuddin, additional, Zhu, Zixiang, additional, Li, Dan, additional, Zhang, Keshan, additional, Zheng, Haixue, additional, and Liu, Xiangtao, additional

Published
2020
Full Text
View/download PDF

18. Seneca Valley Virus 3C pro Cleaves PABPC1 to Promote Viral Replication.

Author

Xue Q, Liu H, Zhu Z, Xue Z, Liu X, and Zheng H

Abstract

Seneca Valley Virus (SVV) is an oncolytic virus of the Picornaviridae family, which has emerged in recent years. The impact of SVV on host cell translation remains unknown. Here, we showed, for the first time, that SVV infection cleaved poly(A) binding protein cytoplasmic 1 (PABPC1). In SVV-infected cells, 50 kDa of the N terminal cleaved band and 25 kDa of the C terminal cleaved band of PABPC1 were detected. Further study showed that the viral protease, 3C pro induced the cleavage of PABPC1 by its protease activity. The SVV strains with inactive point mutants of 3C pro (H48A, C160A or H48A/C160A) can not be rescued by reverse genetics, suggesting that sites 48 and 160 of 3C pro were essential for SVV replication. SVV 3C pro induced the cleavage of PABPC1 at residue 437. A detailed data analysis showed that SVV infection and the overexpression of 3C pro decreased the protein synthesis rates. The protease activity of 3C pro was essential for inhibiting the protein synthesis. Our results also indicated that PABPC1 inhibited SVV replication. These data reveal a novel antagonistic mechanism and pathogenesis mediated by SVV and highlight the importance of 3C pro on SVV replication.

Published
2020
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results