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Oesophageal cancer is a malignant tumor with high morbidity and mortality. Surgical treatment, radiotherapy, and chemotherapy are the most common treatment methods for oesophageal cancer. However, traditional chemotherapy drugs have poor targeting performance and cause serious adverse drug reactions. In this study, a GSH-sensitive material, ATRA-SS-HA, was developed and self-assembled with curcumin, a natural polyphenol antitumor drug, into nanomicelles Cur@ATRA-SS-HA. The micelles had a suitable particle size, excellent drug loading, encapsulation rate, stability, biocompatibility, and stable release behaviour. In the tumor microenvironment, GSH induced disulfide bond rupture in Cur@ATRA-SS-HA and promoted the release of curcumin, improving tumor targeting. Following GSH-induced release, the curcumin IC50 value was significantly lower than that of free curcumin and better than that of 5-FU. In vivo pharmacokinetic experiments showed that the drug-loaded nanomicelles exhibited better metabolic behaviour than free drugs, which greatly increased the blood concentration of curcumin and increased the half-life of the drug. The design of the nanomicelle provides a novel clinical treatment for oesophageal cancer.

To facilitate the better use of RP-3 kerosene in compression ignition engines, the auto-ignition behaviors of RP-3 kerosene spray were experimentally investigated in an optical rapid compression machine. Results show that most of the tests have good ignitability and combustion performance. For all the successful ignited cases, the flame kernel was found to be formed before the steep rise of pressure, which explained that image-based ignition delay time is always shorter than the pressure-based ignition delay time. The effects of ambient environment, injection pressure, and injection delay time on the pressure history, ignition intensity, combustion duration, heat release rate, and other parameters were investigated individually. The ambient environment has a strong influence on ignition delay time by accelerating the chemical reactions, whereas the high injection pressure helps the better vaporization of fuel spray. The effect of injection delay time is non-monotonic as the trade-off relation between heat loss and blending of fuel and oxygen. The heat release rate histories under different conditions were compared and analyzed, and the two-stage heat release phenomenon was observed in the negative temperature coefficient region. The ignition intensity region was determined based on the measured ignition delay times of RP-3 kerosene spray, and multiple linear regression correlation was used to study the ignition delay time sensitivity to multi-factors.