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As the foundation for digitalization, building information modeling (BIM) technology has been widely used in the field of architecture, engineering, construction, and facility management (AEC/FM). Unmanned aerial vehicle (UAV) oblique photogrammetry and laser scanning have become increasingly popular data acquisition techniques for surveying buildings and providing original data for BIM modeling. However, the geometric and topological reconstruction of solid walls, which are among the most important architectural structures in BIM, is still a challenging undertaking. Due to noise and missing data in 3D point clouds, current research mostly focuses on segmenting wall planar surfaces from unstructured 3D point clouds and fitting the plane parameters without considering the thickness or 3D shape of the wall. Point clouds acquired only from the indoor space are insufficient for modeling exterior walls. It is also important to maintain the topological relationships between wall objects to meet the needs of complex BIM modeling. Therefore, in this study, a geometry and topology modeling method is proposed for solid walls in BIM based on photogrammetric meshes and laser point clouds. The method uses a kinetic space-partitioning algorithm to generate the building footprint and indoor floor plan. It classifies interior and exterior wall segments and infers parallel line segments to extract wall centerlines. The topological relationships are reconstructed and maintained to build wall objects with consistency. Experimental results on two datasets, including both photogrammetric meshes and indoor laser point clouds, exhibit more than 90% completeness and correctness, as well as centimeter-level accuracy of the wall surfaces.

Hematopoietic progenitor kinase 1 (HPK1) is a negative regulator of T cell receptor, which has been regarded as a potential target for immunotherapy. Yu et al. observed the off-target effect of the high-throughput screening HPK1 kinase inhibitor hits on JAK1 kinase. The off-target effect is usually due to the lack of specificity of the drug, resulting in toxic side effects. Therefore, exploring the mechanisms to selectively inhibit HPK1 is critical for developing effective and safe inhibitors. In this study, two indazole compounds as HPK1 inhibitors with different selectivity towards JAK1 were used to investigate the selectivity mechanism using multiple computational methods, including conventional molecular dynamics simulations, binding free energy calculations and umbrella sampling simulations. The results indicate that the salt bridge between the inhibitor and residue Asp101 of HPK1 favors their selectivity towards HPK1 over JAK1. Information obtained from this study can be used to discover and design more potent and selective HPK1 inhibitors for immunotherapy.

Clinker bricks were popular as a facade material in the United States between the 1890s and the 1930s. However, this material was unknown to Chinese builders and was seldom found in Chinese modern architecture from 1840 to 1949. The Smart Memorial Gymnasium built in the years 1934–1937 in the Tiancizhuang Campus of Soochow University (Suzhou, China) is one of the rare examples of a building featuring clinker bricks in modern China. Notably, those clinker bricks were not imported but locally manufactured. Despite the heritage significance of the Smart Memorial Gymnasium as part of a major historical and cultural site protected at the national level in China, the history and characteristics of those historical bricks have remained virtually unexplored. This study first provides a historical analysis of those bricks, giving insights into the general knowledge of this construction material around that time based on British and American historical sources from the 19th and 20th centuries, with a focus on historical treaties and documents. This analysis sheds light on the raw materials mixtures of clinker bricks, their manufacturing processes, and their architectural applications at the time. Moreover, this study presents a physicochemical analysis of the clinker bricks employed at Soochow University, focusing on the correlation between historical studies and physicochemical characteristics, as well as the materials’ characteristics that respond to the natural environment. X-ray diffraction (XRD), Raman spectroscopy, scanning electron microscopy with energy dispersive spectroscopy (SEM-EDS), and total immersion tests were employed to investigate the physicochemical properties of the bricks at various locations of the Smart Memorial Gymnasium facades. Our findings deepen the knowledge and understanding of clinker bricks transferred from the West to China in the early 20th century. Additionally, our results reveal the chemical composition and physical characteristics of different types of clinker bricks used in the Smart Memorial Gymnasium, outlining practical implications and future research directions. Overall, this study lays a foundation for the heritage recognition and conservation of Chinese clinker bricks.