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Thalassemia represents one of the most common genetic disorders worldwide, characterized by defects in hemoglobin synthesis. The affected individuals suffer from malfunctioning of one or more of the four globin genes, leading to chronic hemolytic anemia, an imbalance in the hemoglobin chain ratio, iron overload, and ineffective erythropoiesis. Despite the challenges posed by this condition, recent years have witnessed significant advancements in diagnosis, therapy, and transfusion support, significantly improving the prognosis for thalassemia patients. This research empirically evaluates the efficacy of models constructed using classification methods and explores the effectiveness of relevant features that are derived using various machine-learning techniques. Five feature selection approaches, namely Chi-Square (χ2), Exploratory Factor Score (EFS), tree-based Recursive Feature Elimination (RFE), gradient-based RFE, and Linear Regression Coefficient, were employed to determine the optimal feature set. Nine classifiers, namely K-Nearest Neighbors (KNN), Decision Trees (DT), Gradient Boosting Classifier (GBC), Linear Regression (LR), AdaBoost, Extreme Gradient Boosting (XGB), Random Forest (RF), Light Gradient Boosting Machine (LGBM), and Support Vector Machine (SVM), were utilized to evaluate the performance. The χ2 method achieved accuracy, registering 91.56% precision, 91.04% recall, and 92.65% f-score when aligned with the LR classifier. Moreover, the results underscore that amalgamating over-sampling with Synthetic Minority Over-sampling Technique (SMOTE), RFE, and 10-fold cross-validation markedly elevates the detection accuracy for αT patients. Notably, the Gradient Boosting Classifier (GBC) achieves 93.46% accuracy, 93.89% recall, and 92.72% F1 score.

Wetlands provide vital ecological and socioeconomic services but face escalating pressures worldwide. This study undertakes an integrated spatiotemporal assessment of the multifaceted vulnerabilities shaping Khinjhir Lake, an ecologically significant wetland ecosystem in Pakistan, using advanced geospatial and machine learning techniques. Multi-temporal optical remote sensing data from 2000 to 2020 was analyzed through spectral water indices, land cover classification, change detection and risk mapping to examine moisture variability, land cover modifications, area changes and proximity-based threats over two decades. The random forest algorithm attained the highest accuracy (89.5%) for land cover classification based on rigorous k-fold cross-validation, with a training accuracy of 91.2% and a testing accuracy of 87.3%. This demonstrates the model’s effectiveness and robustness for wetland vulnerability modeling in the study area, showing 11% shrinkage in open water bodies since 2000. Inventory risk zoning revealed 30% of present-day wetland areas under moderate to high vulnerability. The cellular automata–Markov (CA–Markov) model predicted continued long-term declines driven by swelling anthropogenic pressures like the 29 million population growth surrounding Khinjhir Lake. The research demonstrates the effectiveness of integrating satellite data analytics, machine learning algorithms and spatial modeling to generate actionable insights into wetland vulnerability to guide conservation planning. The findings provide a robust baseline to inform policies aimed at ensuring the health and sustainable management and conservation of Khinjhir Lake wetlands in the face of escalating human and climatic pressures that threaten the ecological health and functioning of these vital ecosystems.

Remote sensing images are an essential tool for mapping the amount of flood inundation after flood events. For early flood estimation, flood mapping is a crucial component. This study used an integration of geospatial techniques to evaluate the flood extent in District Dera Ghazi Khan, Pakistan. The modified normalized difference water index (MNDWI) was utilized to estimate the flood extent using Landsat data. For a thorough flood investigation, pre-flood, during, and post-flood images were obtained. The analysis enabled us to delineate flood extent as well as flood duration. The result showed that the flood continued for nearly 5 weeks in the study area. This proposed geospatial technique provides a framework for the identification of inundated areas, which allows emergency responses to be focused on newly flooded areas. Hence, the current study offers a novel perspective on flood mapping and significantly contributes to flood monitoring.

The substantial reliance of South Asia (SA) to rain-based agriculture makes the region susceptible to food scarcity due to droughts. Previously, most research on SA has emphasized the meteorological aspects with little consideration of agrarian drought impressions. The insufficient amount of in situ precipitation data across SA has also hindered thorough investigation in the agriculture sector. In recent times, models, satellite remote sensing, and reanalysis products have increased the amount of data. Hence, soil moisture, precipitation, terrestrial water storage (TWS), and vegetation condition index (VCI) products have been employed to illustrate SA droughts from 1982 to 2019 using a standardized index/anomaly approach. Besides, the relationships of these products towards crop production are evaluated using the annual national production of barley, maize, rice, and wheat by computing the yield anomaly index (YAI). Our findings indicate that MERRA-2, CPC, FLDAS (soil moisture), GPCC, and CHIRPS (precipitation) are alike and constant over the entire four regions of South Asia (northwest, southwest, northeast, and southeast). On the other hand, GLDAS and ERA5 remain poor when compared to other soil moisture products and identified drought conditions in regions one (northwest) and three (northeast). Likewise, TWS products such as MERRA-2 TWS and GRACE TWS (2002–2014) followed the patterns of ERA5 and GLDAS and presented divergent and inconsistent drought patterns. Furthermore, the vegetation condition index (VCI) remained less responsive in regions three (northeast) and four (southeast) only. Based on annual crop production data, MERRA-2, CPC, FLDAS, GPCC, and CHIRPS performed fairly well and indicated stronger and more significant associations (0.80 to 0.96) when compared to others. Thus, the current outcomes are imperative for gauging the deficient amount of data in the SA region, as they provide substitutes for agricultural drought monitoring.

Carbon dioxide (CO2) is the most important greenhouse gas and several satellites have been launched to monitor the atmospheric CO2 at regional and global scales. Evaluation of the measurements obtained from these satellites against accurate and precise instruments is crucial. In this work, aircraft measurements of CO2 were carried out over Qinhuangdao, China (39.9354°N, 119.6005°E), on 14, 16, and 19 March 2019 to validate the Greenhous gases Observing SATellite (GOSAT) and the Orbiting Carbon Observatory 2 (OCO-2) CO2 retrievals. The airborne in situ instruments were mounted on a research aircraft and the measurements were carried out between the altitudes of ~0.5 and 8.0 km to obtain the vertical profiles of CO2. The profiles captured a decrease in CO2 concentration from the surface to maximum altitude. Moreover, the vertical profiles from GEOS-Chem and the National Oceanic and Atmospheric Administration (NOAA) CarbonTracker were also compared with in situ and satellite datasets. The satellite and the model datasets captured the vertical structure of CO2 when compared with in situ measurements, which showed good agreement among the datasets. The dry-air column-averaged CO2 mole fractions (XCO2) retrieved from OCO-2 and GOSAT showed biases of 1.33 ppm (0.32%) and −1.70 ppm (−0.41%), respectively, relative to the XCO2 derived from in situ measurements.

A small library of truncated neomycin-conjugates is prepared by consecutive removal of 2,6-diaminoglucose rings, oxidation-reductive amination of ribose, oxidation-conjugation of aminopyridine/aminoquinoline and finally dimerization. The dimeric conjugates were evaluated for antibacterial activity with a unique hemocyanin-based biosensor. Based on the outcome of these results, a second-generation set of monomeric conjugates was prepared and found to display significant antibacterial activity, in particular with respect to kanamycin-resistant E. coli.

Reliable energy forecasting helps managers to prepare future budgets for their buildings. Therefore, a simple, easier, less time consuming and reliable forecasting model which could be used for different types of buildings is desired. In this paper, we have presented a forecasting model based on five years of real data sets for one dependent variable (the daily electricity consumption) and six explanatory variables (ambient temperature, solar radiation, relative humidity, wind speed, weekday index and building type). A single mathematical equation for forecasting daily electricity usage of university buildings has been developed using the Multiple Regression (MR) technique. Data of two such buildings, located at the Southwark Campus of London South Bank University in London, have been used for this study. The predicted test results of MR model are examined and judged against real electricity consumption data of both buildings for year 2011. The results demonstrate that out of six explanatory variables, three variables; surrounding temperature, weekday index and building type have significant influence on buildings energy consumption. The results of this model are associated with a Normalized Root Mean Square Error (NRMSE) of 12% for the administrative building and 13% for the academic building. Finally, some limitations of this study have also been discussed.