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4. The Management of Workplace Violence against Healthcare Workers: A Multidisciplinary Team for Total Worker Health® Approach in a Hospital

Author

Di Prinzio, Reparata Rosa, primary, Bondanini, Giorgia, additional, De Falco, Federica, additional, Vinci, Maria Rosaria, additional, Camisa, Vincenzo, additional, Santoro, Annapaola, additional, De Santis, Marcello, additional, Raponi, Massimiliano, additional, Dalmasso, Guendalina, additional, and Zaffina, Salvatore, additional

Published
2022
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5. Developing a Predictive Grading Model for Children with Gliomas Based on Diffusion Kurtosis Imaging Metrics: Accuracy and Clinical Correlations with Patient Survival

Author

Voicu, Ioan Paul, primary, Napolitano, Antonio, additional, Caulo, Massimo, additional, Dotta, Francesco, additional, Piccirilli, Eleonora, additional, Vinci, Maria, additional, Diomedi-Camassei, Francesca, additional, Lattavo, Lorenzo, additional, Carboni, Alessia, additional, Miele, Evelina, additional, Cacchione, Antonella, additional, Carai, Andrea, additional, Tomà, Paolo, additional, Mastronuzzi, Angela, additional, and Colafati, Giovanna Stefania, additional

Published
2022
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7. Pediatric Diffuse Midline Gliomas: An Unfinished Puzzle

Author

Di Ruscio, Valentina, primary, Del Baldo, Giada, additional, Fabozzi, Francesco, additional, Vinci, Maria, additional, Cacchione, Antonella, additional, de Billy, Emmanuel, additional, Megaro, Giacomina, additional, Carai, Andrea, additional, and Mastronuzzi, Angela, additional

Published
2022
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8. Molecular Landscape in Infant High-Grade Gliomas: A Single Center Experience

Author

Di Ruscio, Valentina, primary, Carai, Andrea, additional, Del Baldo, Giada, additional, Vinci, Maria, additional, Cacchione, Antonella, additional, Miele, Evelina, additional, Rossi, Sabrina, additional, Antonelli, Manila, additional, Barresi, Sabina, additional, Caulo, Massimo, additional, Colafati, Giovanna Stefania, additional, and Mastronuzzi, Angela, additional

Published
2022
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9. Highly Specific Memory B Cells Generation after the 2nd Dose of BNT162b2 Vaccine Compensate for the Decline of Serum Antibodies and Absence of Mucosal IgA

Author

Piano Mortari, Eva, primary, Russo, Cristina, additional, Vinci, Maria Rosaria, additional, Terreri, Sara, additional, Fernandez Salinas, Ane, additional, Piccioni, Livia, additional, Alteri, Claudia, additional, Colagrossi, Luna, additional, Coltella, Luana, additional, Ranno, Stefania, additional, Linardos, Giulia, additional, Agosta, Marilena, additional, Albano, Christian, additional, Agrati, Chiara, additional, Castilletti, Concetta, additional, Meschi, Silvia, additional, Romania, Paolo, additional, Roscilli, Giuseppe, additional, Pavoni, Emiliano, additional, Camisa, Vincenzo, additional, Santoro, Annapaola, additional, Brugaletta, Rita, additional, Magnavita, Nicola, additional, Ruggiero, Alessandra, additional, Cotugno, Nicola, additional, Amodio, Donato, additional, Ciofi Degli Atti, Marta Luisa, additional, Giorgio, Daniela, additional, Russo, Nicoletta, additional, Salvatori, Guglielmo, additional, Corsetti, Tiziana, additional, Locatelli, Franco, additional, Perno, Carlo Federico, additional, Zaffina, Salvatore, additional, and Carsetti, Rita, additional

Published
2021
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10. The Role of Glycemic Variability in Cardiovascular Disorders

Author

Alfieri, Valentina, primary, Myasoedova, Veronika A., additional, Vinci, Maria Cristina, additional, Rondinelli, Maurizio, additional, Songia, Paola, additional, Massaiu, Ilaria, additional, Cosentino, Nicola, additional, Moschetta, Donato, additional, Valerio, Vincenza, additional, Ciccarelli, Michele, additional, Marenzi, Giancarlo, additional, Genovese, Stefano, additional, and Poggio, Paolo, additional

Published
2021
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11. Effectiveness of psychological support to healthcare workers by the occupational health service: a pilot experience

Author

Dalmasso, Guendalina, Di Prinzio, Reparata Rosa, Gilardi, F., De Falco, F., Vinci, Maria Rosaria, Camisa, Vincenzo, Santoro, A., Casasanta, D., Raponi, M., Giorgi, G., Magnavita, Nicola, Zaffina, Salvatore, Dalmasso G., Di Prinzio R. R., Vinci M. R., Camisa V., Magnavita N. (ORCID:0000-0002-0988-7344), Zaffina S. (ORCID:0000-0002-8858-5423), Dalmasso, Guendalina, Di Prinzio, Reparata Rosa, Gilardi, F., De Falco, F., Vinci, Maria Rosaria, Camisa, Vincenzo, Santoro, A., Casasanta, D., Raponi, M., Giorgi, G., Magnavita, Nicola, Zaffina, Salvatore, Dalmasso G., Di Prinzio R. R., Vinci M. R., Camisa V., Magnavita N. (ORCID:0000-0002-0988-7344), and Zaffina S. (ORCID:0000-0002-8858-5423)

Abstract

Work-related stress is a significant risk for healthcare workers (HCWs). This study aims aevaluating the effectiveness of an individual psychological support programme for hospital workersIn all, 35 workers participated (n). A control group of 245 workers (7n) was set. Occupationadistress was measured by the General Health Questionnaire, (GHQ-12), the quality of life by the Short Form-36 health survey, (SF-36), and sickness absence was recorded. Costs and benefits of the service were evaluated and the return on investment (ROI) was calculated. The level of distress was significantly reduced in the treated group at the end of the follow-up (p < 0.001). Quality of life had significantly improved (p < 0.003). A 60% reduction of sickness absence days (SADs) following the intervention was recorded. After the treatment, absenteeism in cases was significantly lower than in controls (p < 0.02). The individual improvement of mental health and quality of life was significantly correlated with the number of meetings with the psychologist (p < 0.01 and p < 0.03, respectively)The recovery of direct costs due to reduced sick leave absence was significantly higher than the costs of the programme; ROI was 2.73. The results must be examined with caution, given the very limited number of workers treated; this first study, however, encouraged us to continue the experience.

Published
2021

12. Effectiveness of Psychological Support to Healthcare Workers by the Occupational Health Service: A Pilot Experience

Author

Dalmasso, Guendalina, primary, Di Prinzio, Reparata Rosa, additional, Gilardi, Francesco, additional, De Falco, Federica, additional, Vinci, Maria Rosaria, additional, Camisa, Vincenzo, additional, Santoro, Annapaola, additional, Casasanta, Daniela, additional, Raponi, Massimiliano, additional, Giorgi, Gabriele, additional, Magnavita, Nicola, additional, and Zaffina, Salvatore, additional

Published
2021
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13. Junctional Adhesion Molecule-C Mediates the Recruitment of Embryonic-Endothelial Progenitor Cells to the Perivascular Niche during Tumor Angiogenesis

Author

Czabanka, Marcus, Petrilli, Lucia Lisa, Elvers-Hornung, Susanne, Bieback, Karen, Imhof, Beat Albert, Vajkoczy, Peter, and Vinci, Maria

Subjects
education, migration, Article, Tight Junctions, lcsh:Chemistry, Mice, Neoplasms, Cell Adhesion, Human Umbilical Vein Endothelial Cells, Animals, Humans, perivascular niche, lcsh:QH301-705.5, Endothelial Progenitor Cells, Neovascularization, Pathologic, Transendothelial and Transepithelial Migration, tumor angiogenesis, endothelial progenitors, humanities, Mice, Inbred C57BL, adhesion, jam-c, lcsh:Biology (General), lcsh:QD1-999, Junctional Adhesion Molecule C, embryonic structures, cardiovascular system, Female, 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit, circulatory and respiratory physiology
Abstract

The homing of Endothelial Progenitor Cells (EPCs) to tumor angiogenic sites has been described as a multistep process, involving adhesion, migration, incorporation and sprouting, for which the underlying molecular and cellular mechanisms are yet to be fully defined. Here, we studied the expression of Junctional Adhesion Molecule-C (JAM-C) by EPCs and its role in EPC homing to tumor angiogenic vessels. For this, we used mouse embryonic-Endothelial Progenitor Cells (e-EPCs), intravital multi-fluorescence microscopy techniques and the dorsal skin-fold chamber model. JAM-C was found to be expressed by e-EPCs and endothelial cells. Blocking JAM-C did not affect adhesion of e-EPCs to endothelial monolayers in vitro but, interestingly, it did reduce their adhesion to tumor endothelium in vivo. The most striking effect of JAM-C blocking was on tube formation on matrigel in vitro and the incorporation and sprouting of e-EPCs to tumor endothelium in vivo. Our results demonstrate that JAM-C mediates e-EPC recruitment to tumor angiogenic sites, i.e., coordinated homing of EPCs to the perivascular niche, where they cluster and interact with tumor blood vessels. This suggests that JAM-C plays a critical role in the process of vascular assembly and may represent a potential therapeutic target to control tumor angiogenesis.

Published
2020

14. Return on investment (ROI) and development of a workplace disability management program in a hospital—a pilot evaluation study

Author

Camisa, Vincenzo, Gilardi, F., Di Brino, E., Santoro, A., Vinci, Maria Rosaria, Sannino, S., Bianchi, N., Mesolella, V., Macina, N., Focarelli, M., Brugaletta, R., Raponi, M., Ferri, L., Cicchetti, Americo, Magnavita, Nicola, Zaffina, Salvatore, Camisa V., Vinci M. R., Cicchetti A. (ORCID:0000-0002-4633-9195), Magnavita N. (ORCID:0000-0002-0988-7344), Zaffina S. (ORCID:0000-0002-8858-5423), Camisa, Vincenzo, Gilardi, F., Di Brino, E., Santoro, A., Vinci, Maria Rosaria, Sannino, S., Bianchi, N., Mesolella, V., Macina, N., Focarelli, M., Brugaletta, R., Raponi, M., Ferri, L., Cicchetti, Americo, Magnavita, Nicola, Zaffina, Salvatore, Camisa V., Vinci M. R., Cicchetti A. (ORCID:0000-0002-4633-9195), Magnavita N. (ORCID:0000-0002-0988-7344), and Zaffina S. (ORCID:0000-0002-8858-5423)

Abstract

The progressive ageing of the working population and the increase in related chronic diseases tend to affect working capacity. The aim of this study was to evaluate a Workplace Disability Management Program (WDMP) within a pediatric hospital. Absenteeism due to healthcare workers’ (HCWs) pre-and post-WDMP and the related costs were used for the program evaluation. The Return on Investment (ROI), the Break-Even Analysis (BEA) and the value of the average annual productivity of HCWs who took advantage of the Disability Management (DM) interventions to assess the economic impact of the program, were also used. The HCWs enrolled in the program were 131 (approximately 4% of hospital staff), of which 89.7% females and with an average age of 50.4 years (SD ± 8.99). Sick leave days of the HCWs involved decreased by 66.6% in the year following the end of WDMP compared to the previous one (p < 0.001). The total estimated cost reduction of absenteeism is 427,896 € over a year. ROI was equal to 27.66 €. BEA indicated that the break-even point was reached by implementing the program on 3.27 HCWs. The program evaluation demonstrated the particular effectiveness of the implemented WDMP model, acting positively on the variables that affect productivity and the limitation to work.

Published
2020

17. Return on Investment (ROI) and Development of a Workplace Disability Management Program in a Hospital—A Pilot Evaluation Study

Author

Camisa, Vincenzo, primary, Gilardi, Francesco, additional, Di Brino, Eugenio, additional, Santoro, Annapaola, additional, Vinci, Maria Rosaria, additional, Sannino, Serena, additional, Bianchi, Natalia, additional, Mesolella, Valentina, additional, Macina, Nadia, additional, Focarelli, Michela, additional, Brugaletta, Rita, additional, Raponi, Massimiliano, additional, Ferri, Livia, additional, Cicchetti, Americo, additional, Magnavita, Nicola, additional, and Zaffina, Salvatore, additional

Published
2020
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18. Differences in Mitochondrial Membrane Potential Identify Distinct Populations of Human Cardiac Mesenchymal Progenitor Cells

Author

Gambini, Elisa, primary, Martinelli, Ilenia, additional, Stadiotti, Ilaria, additional, Vinci, Maria Cristina, additional, Scopece, Alessandro, additional, Eramo, Luana, additional, Sommariva, Elena, additional, Resta, Jessica, additional, Benaouadi, Sabrina, additional, Cogliati, Elisa, additional, Paolin, Adolfo, additional, Parini, Angelo, additional, Pompilio, Giulio, additional, and Savagner, Frederique, additional

Published
2020
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19. Integration of Multiple Platforms for the Analysis of Multifluorescent Marking Technology Applied to Pediatric GBM and DIPG

Author

Pericoli, Giulia, primary, Petrini, Stefania, additional, Giorda, Ezio, additional, Ferretti, Roberta, additional, Ajmone-Cat, Maria Antonietta, additional, Court, Will, additional, Conti, Libenzio Adrian, additional, De Simone, Roberta, additional, Bencivenga, Paola, additional, Palma, Alessia, additional, Di Giannatale, Angela, additional, Jones, Chris, additional, Carai, Andrea, additional, Mastronuzzi, Angela, additional, de Billy, Emmanuel, additional, Locatelli, Franco, additional, and Vinci, Maria, additional

Published
2020
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22. Seasonal Influenza Vaccination in Health Care Workers. A Pre-Post Intervention Study in an Italian Paediatric Hospital

Author

Gilardi, Francesco, primary, Castelli Gattinara, Guido, additional, Vinci, Maria, additional, Ciofi Degli Atti, Marta, additional, Santilli, Veronica, additional, Brugaletta, Rita, additional, Santoro, Annapaola, additional, Montanaro, Rosina, additional, Lavorato, Luisa, additional, Raponi, Massimiliano, additional, and Zaffina, Salvatore, additional

Published
2018
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