1. Gender Differences in the Associations of Plasma Pyridoxal 5′-Phosphate with Plasma Polyunsaturated Fatty Acids among US Young and Middle-Aged Adults: NHANES 2003–2004
- Author
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Tan Li, Adriana Campa, Evelyn B. Enrione, Hyojung Kim, and Vijaya Narayanan
- Subjects
Adult ,Male ,Vitamin ,medicine.medical_specialty ,pyridoxal 5’-phosphate ,National Health and Nutrition Examination Survey ,pyridoxal 5′-phosphate ,lcsh:TX341-641 ,vitamin B6 ,Article ,Young Adult ,chemistry.chemical_compound ,Sex Factors ,Internal medicine ,gender ,medicine ,Humans ,NHANES ,Pyridoxal ,health care economics and organizations ,chemistry.chemical_classification ,Nutrition and Dietetics ,business.industry ,food and beverages ,Metabolism ,Middle Aged ,Nutrition Surveys ,polyunsaturated fatty acid ,Eicosapentaenoic acid ,United States ,Vitamin B 6 ,Cross-Sectional Studies ,Endocrinology ,Socioeconomic Factors ,chemistry ,Docosahexaenoic acid ,Pyridoxal Phosphate ,Vitamin B Complex ,Fatty Acids, Unsaturated ,Linear Models ,Female ,lipids (amino acids, peptides, and proteins) ,Arachidonic acid ,business ,lcsh:Nutrition. Foods and food supply ,Food Science ,Polyunsaturated fatty acid - Abstract
Vitamin B6-restricted diets and low plasma pyridoxal 5′-phosphate (PLP) status altered plasma polyunsaturated fatty acids (PUFA) compositions. Evidence suggests the role of gender in the metabolism of vitamin B6 and PUFA. However, no epidemiologic study examined the impact of gender on the relationship between vitamin B6 and PUFA status in adults. Thus, we investigated whether there were gender differences in the association of vitamin B6 intake and plasma PLP concentration with plasma PUFA concentrations and ratios (eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), arachidonic acid (AA), EPA + DHA, EPA/AA, (EPA + DHA)/AA) in US young/middle-aged adults. In total, 864 participants (20–59 years, 484 men, 380 women) from the National Health and Nutrition Examination Survey (NHANES) 2003–2004 were used for this cross-sectional study. Nutrient intakes were estimated from two 24 h recalls and supplement questionnaires, plasma PLP and PUFA were measured. Multivariate linear regression was utilized to obtain unstandardized (b) and standardized (β) coefficients. Covariates included demographic, socioeconomic, dietary variables, physical activity level, cigarette smoking status, alcohol consumption, prescription medication use, and BMI. There were significant interactions between gender and PLP on EPA (P-interaction = 0.004), DHA (P-interaction = 0.020), EPA + DHA (P-interaction = 0.010), EPA/AA (P-interaction = 0.002), (EPA + DHA)/AA (P-interaction = 0.004), whereas no interaction between gender and B6 intake existed. In gender-stratified analyses, in men, PLP was positively associated with EPA (β = 0.138, b = 0.104, p = 0.0004), DHA (β = 0.101, b = 0.058, p = 0.036), EPA + DHA (β = 0.125, b = 0.073, p = 0.005), EPA/AA (β = 0.144, b = 0.099, p = 0.0002), (EPA + DHA)/AA (β = 0.123, b = 0.068, p = 0.005). However, no associations between PLP and PUFA existed in women. In conclusion, gender differences were found in the relationships between plasma PLP and plasma EPA, DHA, EPA + DHA, EPA/AA, and (EPA + DHA)/AA, with significant direct associations in men only among US young/middle-aged adults.
- Published
- 2021
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