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The Yellow River has a high sand content, and sand deposition in the pipelines behind the pumping station occurs from time to time. It is of great significance to reasonably predict the critical velocity of the small-angled V-inclined water transportation pipes. In this study, a Eulerian multiphase model was employed to simulate the solid–liquid two-phase flow. Based on the conservation of the sand transport rate, the critical velocity of the V-inclined pipe was predicted. The effects of simulated pipeline length, pipe inclination and particle size were investigated. The results show that when the simulated pipeline length reached a certain value, it did not affect the prediction of the critical velocity of the overall pipeline. The ±2∘ pipe inclination had a negligible effect on the critical velocity for transporting small-sized particles, but it led to the nonuniform and asymmetrical distribution of liquid velocity and sand deposition at the different cross-sections. As the particle size increased, the critical velocity also increased. However, the influence of particle size on the critical velocity is currently complicated, resulting in a large difference between numerical simulation and empirical formulas when transporting large-sized particles. Accurate prediction of critical velocity is important for long-distance water transportation pipelines to prevent sand deposition and reduce costs.