1. Alkaloids from Hippeastrum papilio
- Author
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Jaume Bastida, José Angelo S. Zuanazzi, Carles Codina, Francesc Viladomat, Strahil Berkov, and Jean Paulo de Andrade
- Subjects
Magnetic Resonance Spectroscopy ,medicine.drug_class ,Pharmaceutical Science ,Article ,Hippeastrum papilio ,Analytical Chemistry ,lcsh:QD241-441 ,Alkaloids ,lcsh:Organic chemistry ,Alzheimer Disease ,Drug Discovery ,Botany ,Alcaloides ,Liliaceae ,medicine ,Cholinesterases ,Humans ,galanthamine ,2D NMR ,Physical and Theoretical Chemistry ,11β-hydroxygalanthamine ,biology ,Amaril·lidàcies ,Galantamine ,Plant Extracts ,Hydrobromide ,Amaryllidaceae ,Organic Chemistry ,Leucojum ,Alzheimer's disease ,Acetilcolinesterasa ,biology.organism_classification ,Narcissus ,Plant Leaves ,Malaltia d'Alzheimer ,Acetylcholinesterase inhibitor ,Chemistry (miscellaneous) ,Lycoris ,Acetylcholinesterase ,Molecular Medicine ,Cholinesterase Inhibitors ,Chromatography, Thin Layer ,Ungernia - Abstract
Galanthamine, an acetylcholinesterase inhibitor marketed as a hydrobromide salt (Razadyne®, Reminyl®) for the treatment of Alzheimer's disease (AD), is obtained from Amaryllidaceae plants, especially those belonging to the genera Leucojum, Narcissus, Lycoris and Ungernia. The growing demand for galanthamine has prompted searches for new sources of this compound, as well as other bioactive alkaloids for the treatment of AD. In this paper we report the isolation of the new alkaloid 11β-hydroxygalanthamine, an epimer of the previously isolated alkaloid habranthine, which was identified using NMR techniques. It has been shown that 11β-hydroxygalanthamine has an important in vitro acetylcholinesterase inhibitory activity. Additionally, Hippeastrum papilio yielded substantial quantities of galanthamine.
- Published
- 2011
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