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The development of cell-based biomaterial alternatives holds significant promise in tissue engineering applications, but it requires accurate mechanical assessment. Herein, we present the development of a novel 3D-printed confined compression apparatus, fabricated using clear resin, designed to cater to the unique demands of biomaterial developers. Our objective was to enhance the precision of force measurements and improve sample visibility during compression testing. We compared the performance of our innovative 3D-printed confined compression setup to a conventional setup by performing stress relaxation testing on hydrogels with variable degrees of crosslinking. We assessed equilibrium force, aggregate modulus, and peak force. This study demonstrates that our revised setup can capture a larger range of force values while simultaneously improving accuracy. We were able to detect significant differences in force and aggregate modulus measurements of hydrogels with variable degrees of crosslinking using our revised setup, whereas these were indistinguishable with the convectional apparatus. Further, by incorporating a clear resin in the fabrication of the compression chamber, we improved sample visibility, thus enabling real-time monitoring and informed assessment of biomaterial behavior under compressive testing.

Background. As artificial intelligence is expanding its applications in medicine, metabolic imaging is gaining the ability to retrieve data otherwise missed by even an experienced naked eye. Also, new radiopharmaceuticals and peptides aim to increase the specificity of positron emission tomography (PET) scans. Herein, a preliminary experience is reported regarding searching for a texture signature in routinely performed [F18]Fluciclovine imaging in prostate cancer. Materials and methods. Twenty-nine patients who underwent a PET/computed tomography (CT) scan with [18F]Fluciclovine because of biochemical prostate cancer relapse were retrospectively enrolled. First- and second-order radiomic features were manually extracted in lesions visually considered pathologic from the Local Image Features Extraction (LIFEx) platform. Statistical analysis was performed on a database of 29 lesions, one1 per patient. The dataset was split to have 20 lesions for the model training set and 9 lesions for the validation set. The Wilcoxon–Mann–Whitney test was used on the training set to select the most significant features (p-value < 0.05) predicting the dichotomous outcome in a univariate analysis. Results. The best model for predicting the outcome was found to be a multiple logistic linear regression model with two features as variables: an intensity histogram type and a gray-level size zone-based type. Conclusions. Texture analysis of [F18]Fluciclovine PET scans helps in defining prostate cancer relapse in a daily clinical setting.

The anterior cruciate ligament (ACL) is a commonly injured ligament in the knee. Bone tunnel widening is a known phenomenon after soft-tissue ACL reconstruction and etiology and the clinical relevance has not been fully elucidated. Osteoconductive compounds are biomaterials providing an appropriate scaffold for bone formation such as a demineralized bone matrix. Osteoinductive materials contain growth factors stimulating bone lineage cells and bone growth. A possible application of osteoinductive/osteoconductive (OIC) material is in ACL surgery. We hypothesized that OIC placed in ACL bone tunnels: (1) reduces tunnel widening, (2) improves graft maturation, and (3) reduces tunnel ganglion cyst formation. To test this hypothesis, this study evaluated the osteogenic effects of demineralized bone matrix (DBM) and platelet-rich plasma (PRP) on tunnel widening, graft maturation, and ganglion cyst formation. This was a randomized controlled clinical trial pilot study. A total of 26 patients that elected to have ACL reconstruction surgery were randomized between the OIC and control group. Measurements of tunnel expansion and graft-tunnel incorporation were conducted via the quantitative image analysis of MRI scans performed at six months after surgery for both groups. No patients had adverse post-operative reactions or infections. The use of OIC significantly reduced tunnel widening (p < 0.05) and improved graft maturation (p < 0.05). Patients treated with OIC had a significantly lower prevalence of ganglion cyst compared to the control group (p < 0.05). The use of OIC has measurable effects on the reduction of tunnel widening, improved graft maturation, and decreased size of ganglion cyst after ACL reconstruction. This study explored the utilization of biologics to minimize bone tunnel widening in ACL reconstruction surgery.

The Smart Landing Gear system to be developed in the framework of the ANGELA project provides the strain measurements on landing gear structure at landings, and this system should be maintained efficiently under operational conditions. It is intended to assess the relevance of Fiber Bragg Gratings for in-flight testing. To assess the capabilities of the FBG bonding and to analyze the strain transmission conditions from the host structure to the FBG through the bonding layer during the operational phases of landing gears, a long-period cyclic loading test campaign on the bonding layer itself was performed. The primary objective of this fatigue-like test was to prove the ability of FBG sensors to withstand the operational life-cycle of landing gear while providing the same strain transfer function throughout the entire cycle; the secondary objective was to select the most suitable fiber-coating and bonding agents for this application. This document describes the execution and results of the fatigue-like test, intended as a preparatory test campaign to support the preliminary design activities of the Smart Landing System.

The current rapid technological change identifies the evolution of people’s transportation as one of the primary effects. Hybrid-electric propulsion reveals potential advantages, including fuel savings, lower pollution, and reduced noise emissions. It is becoming a viable alternative propulsion technology for ground and marine applications and the aviation sector. Hybrid-electric propulsion systems can meet the high demands of next-generation aircraft in terms of lower operating costs, economy, and fuel efficiency while maintaining high flight performance. Introducing similar disruptive technologies requires an evolution of the traditional certification approach and associated means of compliance. Even if it starts with evaluating a hybrid propulsion system, the proposed process can also be adopted in other areas where disruptive technologies need to be adopted, such as H2 fuel systems and active wings, to summarize some potential applications. The Certification Approach for Disruptive Technologies adopts a top–down process, reversing and mixing the usual certification approach currently used for aircraft. It is based on a safety assessment fully integrated into the system’s development. The result of this process will consist of a list of gaps in certification requirements, their classification based on gap solution impact, and proposals to close those gaps.

Breast implants are widely used for reconstructive and/or cosmetic purposes. Inflammations and infections of breast implants represent important complications in clinical practice. The proper management of complications is necessary: diagnostic imaging plays a key role in detecting sites of inflammation and/or infection. The present review aims to illustrate the radiological findings of these conditions with different imaging techniques, such as mammography (MX), ultrasound (US), magnetic resonance imaging (MRI), and nuclear medicine imaging. A knowledge of these findings is essential for radiologists and nuclear medicine physicians to provide helpful information for the clinical management of these complications.

Weight-on-Wheels (WoW) systems are aimed at indicating if the aircraft weight is loading onto the landing gear and its wheels, even partially. These systems are an integral part of the actuation system for safety-critical applications and shall provide reliable information on the actual operational status of the LG. That information reveals if the vehicle is in flight or on the ground. In this way, several kinds of accidents may be prevented, relating for instance, to the incorrect deployment of the landing gear, or even manoeuvres to a certain extent, therefore protecting the aircraft from dangerous damage. There are different architectures that have been proposed in the bibliography, some of them based on strain gauges deployed on the structure, or on proximity sensors installed on the wheels. Being this device and considered critical for safety, it is convenient to couple it with complementary measurements, recorded and processed by different sources. In general, it can be stated that such an intelligent sensor network may be seen as a fundamental support for proper landing gear deployment. The presented paper reports the results of a preliminary investigation performed by the authors to evaluate the possibility of deploying fibre optics on the landing gear structure as part of a WoW system to retrieve the required information. This choice would have a remarkable effect in terms of significant cabling reduction (a single array of sensing elements could be deployed over a single line), and cost abatement from both a manufacturing and operational point of view. There are many other benefits also when referring to an optical instead of a standard electrical sensor system. Due to its small size and ease of integration into different families of materials, it could be considered a system for monitoring the operating status of most actuators on board modern aircraft.

In aeronautics, hard landing is a critical condition as the aircraft approaches the runway with a vertical velocity that exceeds 2 m/s. Beyond that level, the energy that should be then absorbed by the whole structure could cause severe damage to the landing gear and the whole structural system. This document reports on the set-up, execution and results of a preparatory test campaign performed on a small landing gear (LG) demonstrator instrumented with a fibre-optic sensor system. In detail, a leaf spring landing gear was released from a drop tower to detect information about the strain state and the related acceleration history of some specific components during the impact. The objective of the present research is the development of a method for assessing whether hard landing is experienced, and to what extent. Deformation measurements through an integrated Fibre-Bragg Grating (FBG) network allowed retrieving impact velocity by a devoted, original algorithm. The proposed preliminary methodology is the base for assessing a more complex procedure to correlate structural response to the energy entering the structure during the touchdown event.