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9 results on '"Terrazzano, Giuseppe"'

3. Adaptive and Innate Cytotoxic Effectors in Chronic Lymphocytic Leukaemia (CLL) Subjects with Stable Disease

Author

Rubino, Valentina, primary, Carriero, Flavia, additional, Palatucci, Anna Teresa, additional, Giovazzino, Angela, additional, Leone, Stefania, additional, Nicolella, Valerio, additional, Calabrò, Martina, additional, Montanaro, Rosangela, additional, Brancaleone, Vincenzo, additional, Pane, Fabrizio, additional, Chiurazzi, Federico, additional, Ruggiero, Giuseppina, additional, and Terrazzano, Giuseppe, additional

Published
2023
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4. Pro-Inflammatory and Immunological Profile of Dogs with Myxomatous Mitral Valve Disease

Author

Piantedosi, Diego, primary, Musco, Nadia, additional, Palatucci, Anna Teresa, additional, Carriero, Flavia, additional, Rubino, Valentina, additional, Pizzo, Francesco, additional, Nasir, Saad, additional, Molinaro, Giuseppe, additional, Ruggiero, Giuseppina, additional, Terrazzano, Giuseppe, additional, Lombardi, Pietro, additional, and Cortese, Laura, additional

Published
2022
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5. Superoxide Dismutase-1 Intracellular Content in T Lymphocytes Associates with Increased Regulatory T Cell Level in Multiple Sclerosis Subjects Undergoing Immune-Modulating Treatment

Author

Rubino, Valentina, primary, Palatucci, Anna Teresa, additional, La Rosa, Giuliana, additional, Giovazzino, Angela, additional, Aruta, Francesco, additional, Damiano, Simona, additional, Carriero, Flavia, additional, Santillo, Mariarosaria, additional, Iodice, Rosa, additional, Mondola, Paolo, additional, Ruggiero, Giuseppina, additional, and Terrazzano, Giuseppe, additional

Published
2021
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6. Clinical and Immunological Response in Dogs Naturally Infected by L. infantum Treated with a Nutritional Supplement

Author

Lombardi, Pietro, primary, Palatucci, Anna Teresa, additional, Giovazzino, Angela, additional, Mastellone, Vincenzo, additional, Ruggiero, Giuseppina, additional, Rubino, Valentina, additional, Musco, Nadia, additional, Crupi, Rosalia, additional, Cutrignelli, Monica Isabella, additional, Britti, Domenico, additional, Vassalotti, Giuseppe, additional, Terrazzano, Giuseppe, additional, and Cortese, Laura, additional

Published
2019
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8. Clinical and Immunological Response in Dogs Naturally Infected by L. infantum Treated with a Nutritional Supplement

Author

Domenico Britti, Monica Isabella Cutrignelli, Laura Cortese, Anna Teresa Palatucci, Giuseppina Ruggiero, Pietro Lombardi, Angela Giovazzino, Rosalia Crupi, Vincenzo Mastellone, Giuseppe Vassalotti, Giuseppe Terrazzano, Valentina Rubino, Nadia Musco, Lombardi, Pietro, Teresa Palatucci, Anna, Giovazzino, Angela, Mastellone, Vincenzo, Ruggiero, Giuseppina, Rubino, Valentina, Musco, Nadia, Crupi, Rosalia, Cutrignelli, MONICA ISABELLA, Britti, Domenico, Vassalotti, Giuseppe, Terrazzano, Giuseppe, and Cortese, Laura

Subjects
dogs, Leishmaniasi, T regulatory cells, Population, immunomodulation, Serology, T helper cells, Nutraceutical, lcsh:Zoology, Dog, Canine leishmaniasis, medicine, T regulatory cell, T helper cell, lcsh:QL1-991, education, Leishmaniasis, nutraceuticals, education.field_of_study, lcsh:Veterinary medicine, General Veterinary, biology, business.industry, Leishmaniasis, dogs, nutraceuticals immunomodulation, T helper cells, T regulatory cells, medicine.disease, biology.organism_classification, Visceral leishmaniasis, Immunology, lcsh:SF600-1100, Animal Science and Zoology, Sample collection, Leishmania infantum, business
Abstract

Simple Summary We evaluated the effects of a commercial nutraceutical supplementation in dogs naturally affected by Leishmania infantum. This nutraceutical supplement is proposed to be added to dog diet to foster physiological immune-response during chronic leishmaniasis. Parasite clearance is infrequently obtained by immune response in both the human and canine leishmaniasis. Pharmacological therapies frequently fail in the elimination of L. infantum that could have settled in deep organs, escaping immune responses and therapy. The conventional drug therapy improves clinical signs, reduces parasitemia as well as relapse of infection. This nutraceutical supplementation can improve the impaired immune response of the infected dogs to fight the disease. The use of nutraceuticals as immunomodulators in the treatment of visceral leishmaniasis has generated interest in the current approaches to treat the disease. In this clinical and immunological study, we investigated whether the administration of a nutritional supplement mediates the immune-modulatory response in canine leishmaniosis (CL) and improves the clinical outcome of the disease. With this purpose, we analysed T lymphocyte subsets in peripheral blood (PB) of 12 dogs naturally infected by Leishmania infantum, following treatment with a nutritional supplement. The regulatory T (Treg) cells and the T helper (Th) 1 population were specifically evaluated. The animals underwent complete clinical examination and blood sample collection for haematological, biochemical, serological and immunological analysis before treatment (T0), one month (T30) and 3 months (T90) after the onset of the nutraceutical supplementation. We observed that nutraceutical supplementation was associated with immunomodulation of Th1 response and significant clinical improvement of the animals. No side effects were observed. Therefore, a potential supportive role for the nutraceutical supplement during canine leishmaniasis is proposed.

Published
2019

9. Update of the Genetic Variability of Monkeypox Virus Clade IIb Lineage B.1.

Author

Scarpa F, Azzena I, Ciccozzi A, Branda F, Locci C, Perra M, Pascale N, Romano C, Ceccarelli G, Terrazzano G, Fiori PL, Ciccozzi M, Casu M, and Sanna D

Abstract

From 1 January 2022 to 31 May 2024, the World Health Organization (WHO) reported 97,745 laboratory-confirmed Mpox cases, including 203 deaths, across 116 countries. Despite a 2.3% decrease in new cases in May 2024 compared to April 2024, significant regional variations persist. The African Region reported the highest proportion of new cases, while other regions experienced mixed trends. Phylogenomic analyses of the Mpox virus Clade IIb lineage B.1 reveal stable genetic variability with minimal diversification. The Bayesian Skyline Plot indicates a generally stable viral population size with a modest peak in late 2023, followed by a decline. In general, the data indicate that the MPXV outbreak is primarily localized within a few consistent geographic clusters. The virus's evolution is relatively slow, as indicated by its stable genetic variability, and Clade IIb lineage B.1 does not currently show signs of rapid genetic changes or population growth. The current low level of genetic diversity should not lead to complacency. Ongoing genomic surveillance is essential for effective outbreak management and understanding. This monitoring is crucial for identifying any shifts in the virus's behavior or transmission, allowing for prompt public health responses and adjustments. In addition, continued vigilance is necessary to detect any new variants that might influence the outbreak's trajectory.

Published
2024
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