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Sharpless asymmetric dihydroxylation is an important reaction in the enantioselective synthesis of chiral vicinal diols that involves the treatment of alkene with osmium tetroxide along with optically active quinine ligand. Sharpless introduced this methodology after considering the importance of enantioselectivity in the total synthesis of medicinally important compounds. Vicinal diols, produced as a result of this reaction, act as intermediates in the synthesis of different naturally occurring compounds. Hence, Sharpless asymmetric dihydroxylation plays an important role in synthetic organic chemistry due to its undeniable contribution to the synthesis of biologically active organic compounds. This review emphasizes the significance of Sharpless asymmetric dihydroxylation in the total synthesis of various natural products, published since 2020.

Hiyama cross-coupling is a versatile reaction in synthetic organic chemistry for the construction of carbon–carbon bonds. It involves the coupling of organosilicons with organic halides using transition metal catalysts in good yields and high enantioselectivities. In recent years, hectic progress has been made by researchers toward the synthesis of diversified natural products and pharmaceutical drugs using the Hiyama coupling reaction. This review emphasizes the recent synthetic developments and applications of Hiyama cross-coupling.

This review highlights the underexplored potential and promises of marine bioactive peptides (MBPs) with unique structural, physicochemical, and biological activities to fight against the current and future human pathologies. A particular focus is given to the marine environment as a significant source to obtain or extract high-value MBPs from touched/untouched sources. For instance, marine microorganisms, including microalgae, bacteria, fungi, and marine polysaccharides, are considered prolific sources of amino acids at large, and peptides/polypeptides in particular, with fundamental structural sequence and functional entities of a carboxyl group, amine, hydrogen, and a variety of R groups. Thus, MBPs with tunable features, both structural and functional entities, along with bioactive traits of clinical and therapeutic value, are of ultimate interest to reinforce biomedical settings in the 21st century. On the other front, as the largest biome globally, the marine biome is the so-called “epitome of untouched or underexploited natural resources” and a considerable source with significant potentialities. Therefore, considering their biological and biomedical importance, researchers around the globe are redirecting and/or regaining their interests in valorizing the marine biome-based MBPs. This review focuses on the widespread bioactivities of MBPs, FDA-approved MBPs in the market, sustainable development goals (SDGs), and legislation to valorize marine biome to underlying the impact role of bioactive elements with the related pathways. Finally, a detailed overview of current challenges, conclusions, and future perspectives is also given to satisfy the stimulating demands of the pharmaceutical sector of the modern world.

The present study was conducted to investigate the effects of Cuscuta reflexa extract (CRE) on the activities of germination enzymes, seed germination vigor, biomass production, physio-biochemical attributes, and seed yield of water-stressed wheat plants. Different levels of CRE (0, 10, 20, 30, 40, and 50%), including water soaking, were used as seed priming. Water stress negatively affected the seed germination, germination enzyme activities, growth, yield, and different physio-biochemical attributes of wheat plants. Low doses of CRE (10, 20, and 30%) ameliorated the adverse effects of water stress on seed germination attributes, and activities of germination enzymes, but negative impacts were recorded at higher doses (40 and 50%) of CRE. Water-stressed wheat plants grown from seeds pre-treated with low doses of CRE also showed better growth and yield as compared with non-treated ones, and that was associated with an improvement in water relations, photosynthetic pigments, nutrient acquisition, reduced lipid peroxidation, and better antioxidative defense mechanisms. The maximum increase in seed yield was 14.77 and 12.32%, found in plants grown from seeds treated with 20% and 10% CRE, respectively. In conclusion, it is suggested that using low doses of CRE as seed priming can contribute to better wheat yield under water stress, especially in semi-arid and arid areas.