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2. Comparing TIMP-1 and Hsp70 in Blood and Saliva as Potential Prognostic Markers in HNSCC

Author

Rinecker, Jakob, primary, Roesch, Romina, additional, Krippgans, Sara, additional, Nieberler, Markus, additional, Stark, Leonhard, additional, Stangl, Stefan, additional, Haller, Bernhard, additional, Fritsche, Kristin, additional, Multhoff, Gabriele, additional, Knopf, Andreas, additional, Winter, Christof, additional, Wollenberg, Barbara, additional, and Wirth, Markus, additional

Published
2022
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3. Application of High-Z Gold Nanoparticles in Targeted Cancer Radiotherapy—Pharmacokinetic Modeling, Monte Carlo Simulation and Radiobiological Effect Modeling

Author

Li, Wei Bo, primary, Stangl, Stefan, additional, Klapproth, Alexander, additional, Shevtsov, Maxim, additional, Hernandez, Alicia, additional, Kimm, Melanie A., additional, Schuemann, Jan, additional, Qiu, Rui, additional, Michalke, Bernhard, additional, Bernal, Mario A., additional, Li, Junli, additional, Hürkamp, Kerstin, additional, Zhang, Yibao, additional, and Multhoff, Gabriele, additional

Published
2021
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4. Hsp70 in Liquid Biopsies—A Tumor-Specific Biomarker for Detection and Response Monitoring in Cancer

Author

Werner, Caroline, primary, Stangl, Stefan, additional, Salvermoser, Lukas, additional, Schwab, Melissa, additional, Shevtsov, Maxim, additional, Xanthopoulos, Alexia, additional, Wang, Fei, additional, Dezfouli, Ali Bashiri, additional, Thölke, Dennis, additional, Ostheimer, Christian, additional, Medenwald, Daniel, additional, Windberg, Martin, additional, Bache, Matthias, additional, Schlapschy, Martin, additional, Skerra, Arne, additional, and Multhoff, Gabriele, additional

Published
2021
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5. Exosomal Hsp70 in Liquid Biopsies - A Biomarker for Prediction and Response Monitoring in Cancer

Author

Werner, Caroline, primary, Stangl, Stefan, additional, Salvermoser, Lukas, additional, Schwab, Melissa, additional, Shevstov, Maxim, additional, Xanthopoulos, Alexia, additional, Wang, Fei, additional, Medenwald, Daniel, additional, Windberg, Martin, additional, Bache, Matthias, additional, Schlapschy, Martin, additional, Skerra, Arne, additional, and Multhoff, Gabriele, additional

Published
2021
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6. Time- and Dose-Dependent Effects of Ionizing Irradiation on the Membrane Expression of Hsp70 on Glioma Cells

Author

Fellinger, Helena, Stangl, Stefan, Hernandez, Alicia, Pieper, Marija, Shevstov, Maxim, and Multhoff, Gabriele

Subjects
immunology
Abstract

The major stress-inducible Hsp70 (HSPA1A) is overexpressed in highly aggressive tumor cells including glioblastoma multiforme and presented on their plasma membrane. Ionizing irradiation increases cytosolic and membrane-bound Hsp70 (mHsp70) on tumor cells. Depending on its intracellular or membrane localization, Hsp70 either promotes tumor growth or serves as a target for the innate immune system. To define the optimal window for a therapy with Hsp70-tageting NK cells the kinetics of the mHsp70 density on the plasma membrane of human glioma cells (U87) has been studied after radiotherapy by multiparameter flow cytometry. Cell cycle dependent alterations in the mHsp70 expression were excluded by seeding different cell numbers on day 0. Low dose irradiation (2 Gy) results in a slow upregulation of the mHsp70 density in U87 cells which peaks on day 4 and starts to decline from day 7 onwards. In contrast, higher radiation doses (4 Gy, 6 Gy) resulted in a faster upregulation of mHsp70 expression on days 2 and 1, respectively, followed by a decline from day 5 onwards. Functionally, elevated mHsp70 densities correlate with an improved lysis by Hsp70-targeting NK cells. In summary, the kinetics of changes in the mHsp70 density upon irradiation on tumor cells is time and dose-dependent.

Published
2019

7. Elevated Proportions of Activated Nk Cells at Diagnosis Predict a Favourable Prognosis in Glioblastoma Patients

Author

Lobinger, Dominik, primary, Gempt, Jens, additional, Sievert, Wolfgang, additional, Barz, Melanie, additional, Schmitt, Sven, additional, Nguyen, Huyen, additional, Stangl, Stefan, additional, Werner, Caroline, additional, Wang, Fei, additional, Wu, Zhiyuan, additional, Fan, Hengyi, additional, Zanth, Hannah, additional, Shevtsov, Maxim, additional, Pilz, Mathias, additional, Riederer, Isabelle, additional, Schwab, Melissa, additional, Schlegel, Juergen, additional, and Multhoff, Gabriele, additional

Published
2021
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8. Elevated Proportions of Activated NK Cells at Diagnosis Predict a Favourable Prognosis in Glioblastoma Patients

Author

Lobinger, Dominik, primary, Gempt, Jens, additional, Sievert, Wolfgang, additional, Barz, Melanie, additional, Schmitt, Sven, additional, Nguyen, Huyen, additional, Stangl, Stefan, additional, Werner, Caroline, additional, Wang, Fei, additional, Wu, Zhiyuan, additional, Fan, Hengyi, additional, Zanth, Hannah, additional, Shevtsov, Maxim, additional, Pilz, Matthias, additional, Riederer, Isabelle, additional, Schwab, Melissa, additional, Schlegel, Juergen, additional, and Multhoff, Gabriele, additional

Published
2020
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9. Gold Nanoparticle Mediated Multi-Modal CT Imaging of Hsp70 Membrane-Positive Tumors

Author

Kimm, Melanie A., primary, Shevtsov, Maxim, additional, Werner, Caroline, additional, Sievert, Wolfgang, additional, Zhiyuan, Wu, additional, Schoppe, Oliver, additional, Menze, Bjoern H., additional, Rummeny, Ernst J., additional, Proksa, Roland, additional, Bystrova, Olga, additional, Martynova, Marina, additional, Multhoff, Gabriele, additional, and Stangl, Stefan, additional

Published
2020
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10. Gold Nanoparticle Mediated Multi-Modal CT Imaging of 3 Hsp70 Membrane Positive Tumors

Author

Kimm, Melanie A., primary, Shevtsov, Maxim, additional, Werner, Caroline, additional, Sievert, Wolfgang, additional, Wu, Zhiyuan, additional, Schoppe, Oliver, additional, Menze, Bjoern H., additional, Rummeny, Ernst J., additional, Proksa, Roland, additional, Bystrova, Olga, additional, Martynova, Marina, additional, Multhoff, Gabriele, additional, and Stangl, Stefan, additional

Published
2020
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