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In the growing field of personalized medicine, non-invasive wearable devices and sensors are valuable diagnostic tools for the real-time monitoring of physiological and biokinetic signals. Among all the possible multiple (bio)-entities, pH is important in defining health-related biological information, since its variations or alterations can be considered the cause or the effect of disease and disfunction within a biological system. In this work, an innovative (bio)-electrochemical flexible pH sensor was proposed by realizing three electrodes (working, reference, and counter) directly on a polyimide (Kapton) sheet through the implementation of CO 2 laser writing, which locally converts the polymeric sheet into a laser-induced graphene material (LIG electrodes), preserving inherent mechanical flexibility of Kapton. A uniform distribution of nanostructured PEDOT:PSS was deposited via ultrasonic spray coating onto an LIG working electrode as the active material for pH sensing. With a pH-sensitive PEDOT coating, this flexible sensor showed good sensitivity defined through a linear Nernstian slope of (75.6 ± 9.1) mV/pH, across a pH range from 1 to 7. We demonstrated the capability to use this flexible pH sensor during dynamic experiments, and thus concluded that this device was suitable to guarantee an immediate response and good repeatability by measuring the same OCP values in correspondence with the same pH applied.