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Your search keyword '"Solovyeva, Valeriya"' showing total 28 results
Start Over Author "Solovyeva, Valeriya" Publisher mdpi ag
28 results on '"Solovyeva, Valeriya"'

18. Serum Cytokine Profile, Beta-Hexosaminidase A Enzymatic Activity and GM2 Ganglioside Levels in the Plasma of a Tay-Sachs Disease Patient after Cord Blood Cell Transplantation and Curcumin Administration: A Case Report

Author

Shaimardanova, Alisa A., primary, Chulpanova, Daria S., additional, Solovyeva, Valeriya V., additional, Garanina, Ekaterina E., additional, Salafutdinov, Ilnur I., additional, Laikov, Alexander Vladimirovich, additional, Kursenko, Vadim V., additional, Chakrabarti, Lisa, additional, Zakharova, Ekaterina Yu., additional, Bukina, Tatiana M., additional, Baydakova, Galina V., additional, and Rizvanov, Albert Anatolyevich, additional

Published
2021
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19. Proangiogenic Effect of 2A-Peptide Based Multicistronic Recombinant Constructs Encoding VEGF and FGF2 Growth Factors

Author

Gatina, Dilara Z., primary, Garanina, Ekaterina E., additional, Zhuravleva, Margarita N., additional, Synbulatova, Gulnaz E., additional, Mullakhmetova, Adelya F., additional, Solovyeva, Valeriya V., additional, Kiyasov, Andrey P., additional, Rutland, Catrin S., additional, Rizvanov, Albert A., additional, and Salafutdinov, Ilnur I., additional

Published
2021
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20. Cytochalasin B-Induced Membrane Vesicles from Human Mesenchymal Stem Cells Overexpressing IL2 Are Able to Stimulate CD8+ T-Killers to Kill Human Triple Negative Breast Cancer Cells

Author

Chulpanova, Daria S., primary, Gilazieva, Zarema E., additional, Kletukhina, Sevindzh K., additional, Aimaletdinov, Aleksandr M., additional, Garanina, Ekaterina E., additional, James, Victoria, additional, Rizvanov, Albert A., additional, and Solovyeva, Valeriya V., additional

Published
2021
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23. Human Mesenchymal Stem Cells Overexpressing Interleukin 2 Can Suppress Proliferation of Neuroblastoma Cells in Co-Culture and Activate Mononuclear Cells In Vitro

Author

Chulpanova, Daria S., primary, Solovyeva, Valeriya V., additional, James, Victoria, additional, Arkhipova, Svetlana S., additional, Gomzikova, Marina O., additional, Garanina, Ekaterina E., additional, Akhmetzyanova, Elvira R., additional, Tazetdinova, Leysan G., additional, Khaiboullina, Svetlana F., additional, and Rizvanov, Albert A., additional

Published
2020
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26. Recombinant Viruses for Cancer Therapy

Author

Chulpanova, Daria, primary, Solovyeva, Valeriya, additional, Kitaeva, Kristina, additional, Dunham, Stephen, additional, Khaiboullina, Svetlana, additional, and Rizvanov, Albert, additional

Published
2018
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27. Growth Factors and Their Application in the Therapy of Hereditary Neurodegenerative Diseases.

Author

Issa S, Fayoud H, Shaimardanova A, Sufianov A, Sufianova G, Solovyeva V, and Rizvanov A

Abstract

Hereditary neurodegenerative diseases (hNDDs) such as Alzheimer's, Parkinson's, Huntington's disease, and others are primarily characterized by their progressive nature, severely compromising both the cognitive and motor abilities of patients. The underlying genetic component in hNDDs contributes to disease risk, creating a complex genetic landscape. Considering the fact that growth factors play crucial roles in regulating cellular processes, such as proliferation, differentiation, and survival, they could have therapeutic potential for hNDDs, provided appropriate dosing and safe delivery approaches are ensured. This article presents a detailed overview of growth factors, and explores their therapeutic potential in treating hNDDs, emphasizing their roles in neuronal survival, growth, and synaptic plasticity. However, challenges such as proper dosing, delivery methods, and patient variability can hinder their clinical application.

Published
2024
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28. Serum Cytokine Profile, Beta-Hexosaminidase A Enzymatic Activity and GM 2 Ganglioside Levels in the Plasma of a Tay-Sachs Disease Patient after Cord Blood Cell Transplantation and Curcumin Administration: A Case Report.

Author

Shaimardanova AA, Chulpanova DS, Solovyeva VV, Garanina EE, Salafutdinov II, Laikov AV, Kursenko VV, Chakrabarti L, Zakharova EY, Bukina TM, Baydakova GV, and Rizvanov AA

Abstract

Tay-Sachs disease (TSD) is a progressive neurodegenerative disorder that occurs due to a deficiency of a β hexosaminidase A (HexA) enzyme, resulting in the accumulation of GM 2 gangliosides. In this work, we analyzed the effect of umbilical cord blood cell transplantation (UCBCT) and curcumin administration on the course of the disease in a patient with adult TSD. The patient's serum cytokine profile was determined using multiplex analysis. The level of GM 2 gangliosides in plasma was determined using mass spectrometry. The enzymatic activity of HexA in the plasma of the patient was assessed using a fluorescent substrate assay. The HexA α-subunit (HexA) concentration was determined using ELISA. It was shown that both UCBCT and curcumin administration led to a change in the patient's cytokine profile. The UCBCT resulted in an increase in the concentration of HexA in the patient's serum and in an improvement in the patient's neurological status. However, neither UCBCT nor curcumin were able to alter HexA activity and the level of GM 2 in patient's plasma. The data obtained indicate that UCBCT and curcumin administration can alter the immunity of a patient with TSD, reduce the level of inflammatory cytokines and thereby improve the patient's condition.

Published
2021
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