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Background: Candida auris is an emerging multidrug-resistant fungal pathogen that represents a current serious threat to healthcare settings. Objective: The objective was to determine the prevalence of C. auris in a Riyadh hospital since its initial detection in late 2019. Methods: Using an adapted risk assessment tool, we reviewed the charts and medical files of all suspected and confirmed cases of C. auris infections reported at King Khalid University Hospital, Riyadh, between November 2019 and December 2022. Anonymized data were retrieved in a pre-established datasheet and analyzed to determine the epidemiological characteristics of C. auris infections in our facility. We analyzed prevalence by age, gender, risk factors, and according to sampling source. Results: Of the 53 confirmed C. auris-positive cases during the study period, 33 (62%) were males. Their ages ranged between 15 and 98, with most positive cases occurring in those aged 50 and above. Only one of the confirmed cases was hospital-acquired. All patients had at least one risk factor, and urine samples yielded the greatest number of positive cases, while admission to healthcare facilities constituted the highest risk in our study. Conclusion: Establishing a local prevalence pattern could serve as a baseline/benchmark to compare with regional and international benchmarks.

Helicobacter pylori (H. pylori) is the most prevalent etiology of gastritis worldwide. H. pylori management depends mainly on antibiotics, especially the triple therapy formed of clarithromycin, amoxicillin, and proton pump inhibitors. Lately, many antibiotic-resistant strains have emerged, leading to a decrease in the eradication rates of H. pylori. Polaprezinc (PZN), a mucosal protective zinc-L-carnosine complex, may be a non-antibiotic agent to treat H. pylori without the risk of resistance. We performed a systematic review and meta-analysis to evaluate the efficacy and safety of a PZN-based regimen for the eradication of H. pylori. This study used a systematic review and meta-analysis synthesizing randomized controlled trials (RCTs) from WOS, SCOPUS, EMBASE, PubMed, and Google Scholar until 25 July 2022. We used the odds ratio (OR) for dichotomous outcomes presented with the corresponding 95% confidence interval (CI). We registered our protocol in PROSPERO with ID: CRD42022349231. We included 3 trials with a total of 396 participants who were randomized to either PZN plus triple therapy (n = 199) or triple therapy alone (control) (n = 197). Pooled OR found a statistical difference favoring the PZN arm in the intention to treat and per protocol H. pylori eradication rates (OR: 2.01 with 95% CI [1.27, 3.21], p = 0.003) and (OR: 2.65 with 95% CI [1.55, 4.54], p = 0.0004), respectively. We found no statistical difference between the two groups regarding the total adverse events (OR: 1.06 with 95% CI [0.55, 2.06], p = 0.85). PZN, when added to the triple therapy, yielded a better effect concerning the eradication rates of H. pylori with no difference in adverse event rates, and thus can be considered a valuable adjuvant for the management of H. pylori. However, the evidence is still scarce, and larger trials are needed to confirm or refute our findings.

The results show that Wood Chips of Acacia Nilotica trees available in Sudan lands can be successfully used in the gasification process and, on the same basis, as a bio-renewable energy resource. Simulation models were used to characterize the air gasification process integrated with a Regenerative Gas Turbine Unit. The results revealed that at a moisture content of 12%, gasification temperature of 1500 K, pressure of 20 bar, and air-like gasification medium, the biomass gasifier’s flow rate is higher at higher syngas rates. The results verified that there is an optimum ER for each syngas rate, in which the slow growth of the ER revealed the maximum gasifier biomass flow rate. For ER growth at lower levels, the specific fuel consumption (SFC) of the RGT Unit declines sharply from the maximum value reached at 0.27 kg/kW·h at an ER of 5% to the minimum value reached at 0.80 kg/kW·h at an ER of 25% for the lowest gasification temperature of 1000 K. Moreover, ER growths at low levels have a significant effect on the RGT plant’s performance, leading to increased RGT thermal efficiency. The increase in the biomass moisture content led to a sharp decrease in the RGT thermal efficiency. The RGT thermal efficiency remains high at higher gasification pressure. The results revealed that the syngas lower heating value remains high at lower produced syngas rates. At the optimum ER, the H2 mole fraction depicted a value of 1.25%, 0.85% of CO, and 10.50% of CH4 for a lower heating value of 38 MJ/kg syngas. It is shown that the gasification air entered into the gasifier decreases amid the increase in the biomass moisture content. At different syngas rates (3–10 kg/s) and optimum ER, the results predicted that the Wood Chip biomass flow rates decrease when the gasifier efficiency increases. The simulation model revealed that ER growths at lower levels have a significant effect on increasing the power of the RGT plant.