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9 results on '"Sahnane, Nora"'

1. Clinical Relevance and Interplay between miRNAs in Influencing Glioblastoma Multiforme Prognosis

Author

Epistolio, Samantha, primary, Dazio, Giulia, additional, Zaed, Ismail, additional, Sahnane, Nora, additional, Cipriani, Debora, additional, Polinelli, Francesco, additional, Barizzi, Jessica, additional, Spina, Paolo, additional, Stefanini, Federico Mattia, additional, Cerati, Michele, additional, Balbi, Sergio, additional, Mazzucchelli, Luca, additional, Sessa, Fausto, additional, Pesce, Gianfranco Angelo, additional, Reinert, Michael, additional, Cardia, Andrea, additional, Marchi, Francesco, additional, and Frattini, Milo, additional

Published
2024
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3. Identification of MGMT Downregulation Induced by miRNA in Glioblastoma and Possible Effect on Temozolomide Sensitivity

Author

Cardia, Andrea, primary, Epistolio, Samantha, additional, Zaed, Ismail, additional, Sahnane, Nora, additional, Cerutti, Roberta, additional, Cipriani, Debora, additional, Barizzi, Jessica, additional, Spina, Paolo, additional, Stefanini, Federico Mattia, additional, Cerati, Michele, additional, Balbi, Sergio, additional, Mazzucchelli, Luca, additional, Sessa, Fausto, additional, Pesce, Gianfranco Angelo, additional, Reinert, Michael, additional, Frattini, Milo, additional, and Marchi, Francesco, additional

Published
2023
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5. Methylation Drivers and Prognostic Implications in Sinonasal Poorly Differentiated Carcinomas

Author

Libera, Laura, primary, Ottini, Giorgia, additional, Sahnane, Nora, additional, Pettenon, Fabiana, additional, Turri-Zanoni, Mario, additional, Lambertoni, Alessia, additional, Chiaravalli, Anna Maria, additional, Leone, Federico, additional, Battaglia, Paolo, additional, Castelnuovo, Paolo, additional, Uccella, Silvia, additional, Furlan, Daniela, additional, Facco, Carla, additional, and Sessa, Fausto, additional

Published
2021
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6. MYD88L265P Detection in IgM Monoclonal Gammopathies: Methodological Considerations for Routine Implementation

Author

Ferrante, Martina, primary, Furlan, Daniela, additional, Zibellini, Silvia, additional, Borriero, Michela, additional, Candido, Chiara, additional, Sahnane, Nora, additional, Uccella, Silvia, additional, Genuardi, Elisa, additional, Alessandria, Beatrice, additional, Bianchi, Benedetta, additional, Mora, Barbara, additional, Grimaldi, Daniele, additional, Defrancesco, Irene, additional, Jiménez, Cristina, additional, Cavallo, Federica, additional, Ferrero, Dario, additional, Dogliotti, Irene, additional, Merli, Michele, additional, Varettoni, Marzia, additional, Ferrero, Simone, additional, and Drandi, Daniela, additional

Published
2021
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7. BRCA Methylation Testing Identifies a Subset of Ovarian Carcinomas without Germline Variants That Can Benefit from PARP Inhibitor

Author

Sahnane, Nora, primary, Carnevali, Ileana, additional, Formenti, Giorgio, additional, Casarin, Jvan, additional, Facchi, Sofia, additional, Bombelli, Raffaella, additional, Di Lauro, Eleonora, additional, Memoli, Domenico, additional, Salvati, Annamaria, additional, Rizzo, Francesca, additional, Sessa, Fausto, additional, and Tibiletti, Maria Grazia, additional

Published
2020
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9. MYD88 L265P Detection in IgM Monoclonal Gammopathies: Methodological Considerations for Routine Implementation.

Author

Ferrante M, Furlan D, Zibellini S, Borriero M, Candido C, Sahnane N, Uccella S, Genuardi E, Alessandria B, Bianchi B, Mora B, Grimaldi D, Defrancesco I, Jiménez C, Cavallo F, Ferrero D, Dogliotti I, Merli M, Varettoni M, Ferrero S, and Drandi D

Abstract

In IgM monoclonal gammopathies MYD88 L265P is a prognostic and predictive biomarker of therapy response. MYD88 L265P detection is mainly performed by allele-specific quantitative PCR (ASqPCR), however recently, droplet digital PCR (ddPCR) has been proved to be suitable for MYD88 L265P screening and minimal residual disease monitoring (MRD). This study compared ASqPCR and ddPCR to define the most sensitive method for MYD88 L265P detection in bone marrow (BM), peripheral blood (PB) sorted or unsorted CD19+ cells, and in plasma cell-free DNA (cfDNA). Overall, the analysis showed a good concordance rate (74%) between the two methods, especially in BM samples, while discordances (26%) were mostly in favor of ddPCR (ddPCR+ vs. ASqPCR-) and were particularly evident in samples with low mutational burden, such as PB and cfDNA. This study highlights ddPCR as a feasible approach for MYD88 L265P detection across different specimen types (including cfDNA). Interestingly, its high sensitivity makes CD19+ selection dispensable. On the other hand, our results showed that MYD88 L265P detection on PB samples, especially with ASqPCR, is suboptimal for screening and MRD analysis. Finally, significantly different MYD88 L265P mutational levels observed between Waldenström Macroglobulinemia and IgM monoclonal gammopathy of undetermined significance patients suggest the need for further studies in order to identify possible correlations between mutational levels and risk of progression to Waldenström.

Published
2021
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