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Your search keyword '"Royo, Jose Luís"' showing total 2 results
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2 results on '"Royo, Jose Luís"'

1. Mendelian Randomisation Confirms the Role of Y-Chromosome Loss in Alzheimer’s Disease Aetiopathogenesis in Men

Author

García-González, Pablo, primary, de Rojas, Itziar, additional, Moreno-Grau, Sonia, additional, Montrreal, Laura, additional, Puerta, Raquel, additional, Alarcón-Martín, Emilio, additional, Quintela, Inés, additional, Orellana, Adela, additional, Andrade, Victor, additional, Adami, Pamela V. Martino, additional, Heilmann-Heimbach, Stefanie, additional, Gomez-Garre, Pilar, additional, Periñán, María Teresa, additional, Alvarez, Ignacio, additional, Diez-Fairen, Monica, additional, Nuñez Llaves, Raul, additional, Olivé Roig, Claudia, additional, Garcia-Ribas, Guillermo, additional, Menéndez-González, Manuel, additional, Martínez, Carmen, additional, Aguilar, Miquel, additional, Buongiorno, Mariateresa, additional, Franco-Macías, Emilio, additional, Saez, Maria Eugenia, additional, Cano, Amanda, additional, Bullido, Maria J., additional, Real, Luis Miguel, additional, Rodríguez-Rodríguez, Eloy, additional, Royo, Jose Luís, additional, Álvarez, Victoria, additional, Pastor, Pau, additional, Piñol-Ripoll, Gerard, additional, Mir, Pablo, additional, Lara, Miguel Calero, additional, Padilla, Miguel Medina, additional, Sánchez-Juan, Pascual, additional, Carracedo, Angel, additional, Valero, Sergi, additional, Hernandez, Isabel, additional, Tàrraga, Lluis, additional, Ramirez, Alfredo, additional, Boada, Mercé, additional, and Ruiz, Agustín, additional

Published
2023
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2. Genomic Characterization of Host Factors Related to SARS-CoV-2 Infection in People with Dementia and Control Populations: The GR@ACE/DEGESCO Study.

Author

de Rojas I, Hernández I, Montrreal L, Quintela I, Calero M, Royo JL, Huerto Vilas R, González-Pérez A, Franco-Macías E, Macías J, Menéndez-González M, Frank-García A, Diez-Fairen M, Lage C, García-Madrona S, Aguilera N, García-González P, Puerta R, Sotolongo-Grau O, Alonso-Lana S, Rábano A, Arias Pastor A, Pastor AB, Corma-Gómez A, Martín Montes A, Martínez Rodríguez C, Buiza-Rueda D, Periñán MT, Rodriguez-Rodriguez E, Alvarez I, Rosas Allende I, Pineda JA, Bernal Sánchez-Arjona M, Fernández-Fuertes M, Mendoza S, Del Ser T, Gr Ace/Degesco Consortium, Garcia-Ribas G, Sánchez-Juan P, Pastor P, Bullido MJ, Álvarez V, Real LM, Mir P, Piñol-Ripoll G, García-Alberca JM, Medina M, Orellana A, Butler CR, Marquié M, Sáez ME, Carracedo Á, Tárraga L, Boada M, and Ruiz A

Abstract

Emerging studies have suggested several chromosomal regions as potential host genetic factors involved in the susceptibility to SARS-CoV-2 infection and disease outcome. We nested a COVID-19 genome-wide association study using the GR@ACE/DEGESCO study, searching for susceptibility factors associated with COVID-19 disease. To this end, we compared 221 COVID-19 confirmed cases with 17,035 individuals in whom the COVID-19 disease status was unknown. Then, we performed a meta-analysis with the publicly available data from the COVID-19 Host Genetics Initiative. Because the APOE locus has been suggested as a potential modifier of COVID-19 disease, we added sensitivity analyses stratifying by dementia status or by disease severity. We confirmed the existence of the 3p21.31 region ( LZTFL1, SLC6A20 ) implicated in the susceptibility to SARS-CoV-2 infection and TYK2 gene might be involved in COVID-19 severity. Nevertheless, no statistically significant association was observed in the COVID-19 fatal outcome or in the stratified analyses (dementia-only and non-dementia strata) for the APOE locus not supporting its involvement in SARS-CoV-2 pathobiology or COVID-19 prognosis.

Published
2021
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