Search

Your search keyword '"Riner, Andrea N."' showing total 8 results
Start Over Author "Riner, Andrea N." Publisher mdpi ag
8 results on '"Riner, Andrea N."'

8. Translocation of Oral Microbiota into the Pancreatic Ductal Adenocarcinoma Tumor Microenvironment.

Author

McKinley KNL, Herremans KM, Riner AN, Vudatha V, Freudenberger DC, Hughes SJ, Triplett EW, and Trevino JG

Abstract

Oral dysbiosis has long been associated with pancreatic ductal adenocarcinoma (PDAC). In this work, we explore the relationship between the oral and tumor microbiomes of patients diagnosed with PDAC. Salivary and tumor microbiomes were analyzed using a variety of sequencing methods, resulting in a high prevalence and relative abundance of oral bacteria, particularly Veillonella and Streptococcus , within tumor tissue. The most prevalent and abundant taxon found within both saliva and tumor tissue samples, Veillonella atypica , was cultured from patient saliva, sequenced and annotated, identifying genes that potentially contribute to tumorigenesis. High sequence similarity was observed between sequences recovered from patient matched saliva and tumor tissue, indicating that the taxa found in PDAC tumors may derive from the mouth. These findings may have clinical implications in the care and treatment of patients diagnosed with PDAC.

Published
2023
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results