1. Isoforms of Base Excision Repair Enzymes Produced by Alternative Splicing
- Author
-
Elizaveta O. Boldinova, Dmitry O. Zharkov, Alena V. Makarova, and Rafil Khairullin
- Subjects
0301 basic medicine ,Gene isoform ,DNA Repair ,DNA polymerase beta ,Review ,Biology ,Catalysis ,Inorganic Chemistry ,lcsh:Chemistry ,Mice ,03 medical and health sciences ,chemistry.chemical_compound ,alternative splicing ,0302 clinical medicine ,DNA-(Apurinic or Apyrimidinic Site) Lyase ,Animals ,Humans ,Protein Isoforms ,splice ,RNA, Messenger ,Physical and Theoretical Chemistry ,Molecular Biology ,lcsh:QH301-705.5 ,Spectroscopy ,chemistry.chemical_classification ,Organic Chemistry ,Alternative splicing ,apurinic/apyrimidinic endonuclease ,General Medicine ,Base excision repair ,Rats ,Computer Science Applications ,Cell biology ,DNA Repair Enzymes ,030104 developmental biology ,Enzyme ,chemistry ,lcsh:Biology (General) ,lcsh:QD1-999 ,DNA glycosylase ,DNA glycosylases ,030220 oncology & carcinogenesis ,Intracellular transport - Abstract
Transcripts of many enzymes involved in base excision repair (BER) undergo extensive alternative splicing, but functions of the corresponding alternative splice variants remain largely unexplored. In this review, we cover the studies describing the common alternatively spliced isoforms and disease-associated variants of DNA glycosylases, AP-endonuclease 1, and DNA polymerase beta. We also discuss the roles of alternative splicing in the regulation of their expression, catalytic activities, and intracellular transport.
- Published
- 2019