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3. The METTL3 RNA Methyltransferase Regulates Transcriptional Networks in Prostate Cancer

Author

Haigh, Daisy B., primary, Woodcock, Corinne L., additional, Lothion-Roy, Jennifer, additional, Harris, Anna E., additional, Metzler, Veronika M., additional, Persson, Jenny L., additional, Robinson, Brian D., additional, Khani, Francesca, additional, Alsaleem, Mansour, additional, Ntekim, Atara, additional, Madhusudan, Srinivasan, additional, Davis, Melissa B., additional, Laursen, Kristian B., additional, Gudas, Lorraine J., additional, Rutland, Catrin S., additional, Toss, Michael S., additional, Archer, Nathan, additional, Bodi, Zsuzsanna, additional, Rakha, Emad A., additional, Fray, Rupert G., additional, Jeyapalan, Jennie N., additional, and Mongan, Nigel P., additional

Published
2022
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5. Fluorescent Molecularly Imprinted Polymer Layers against Sialic Acid on Silica-Coated Polystyrene Cores—Assessment of the Binding Behavior to Cancer Cells

Author

Beyer, Sarah, primary, Kimani, Martha, additional, Zhang, Yuecheng, additional, Verhassel, Alejandra, additional, Sternbæk, Louise, additional, Wang, Tianyan, additional, Persson, Jenny L., additional, Härkönen, Pirkko, additional, Johansson, Emil, additional, Caraballo, Remi, additional, Elofsson, Mikael, additional, Gawlitza, Kornelia, additional, Rurack, Knut, additional, Ohlsson, Lars, additional, El-Schich, Zahra, additional, Wingren, Anette Gjörloff, additional, and Stollenwerk, Maria M., additional

Published
2022
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6. Sialic Acid as a Biomarker Studied in Breast Cancer Cell Lines In Vitro Using Fluorescent Molecularly Imprinted Polymers

Author

El-Schich, Zahra, Zhang, Yuecheng, Göransson, Tommy, Dizeyi, Nishtman, Persson, Jenny L., Johansson, Emil, Caraballo, Remi, Elofsson, Mikael, Shinde, Sudhirkumar, Sellergren, Börje, and Wingren, Anette Gjörloff

Subjects
lcsh:T, Cell- och molekylärbiologi, lcsh:Technology, Sialic acid, lcsh:QC1-999, Analytical Chemistry, lcsh:Chemistry, Breast cancer, breast cancer, Epithelial cell adhesion molecule, lcsh:Biology (General), lcsh:QD1-999, sialic acid, lcsh:TA1-2040, Molecularly imprinted polymers, Analytisk kemi, Nanoparticles, molecularly imprinted polymers, nanoparticles, epithelial cell adhesion molecule, lcsh:Engineering (General). Civil engineering (General), lcsh:QH301-705.5, Cell and Molecular Biology, lcsh:Physics
Abstract

Sialylations are post-translational modifications of proteins and lipids that play important roles in many cellular events, including cell-cell interactions, proliferation, and migration. Tumor cells express high levels of sialic acid (SA), which are often associated with the increased invasive potential in clinical tumors, correlating with poor prognosis. To overcome the lack of natural SA-receptors, such as antibodies and lectins with high enough specificity and sensitivity, we have used molecularly imprinted polymers (MIPs), or “plastic antibodies”, as nanoprobes. Because high expression of epithelial cell adhesion molecule (EpCAM) in primary tumors is often associated with proliferation and a more aggressive phenotype, the expression of EpCAM and CD44 was initially analyzed. The SA-MIPs were used for the detection of SA on the cell surface of breast cancer cells. Lectins that specifically bind to the a-2,3 SA and a-2,6 SA variants were used for analysis of SA expression, with both flow cytometry and confocal microscopy. Here we show a correlation of EpCAM and SA expression when using the SA-MIPs for detection of SA. We also demonstrate the binding pattern of the SA-MIPs on the breast cancer cell lines using confocal microscopy. Pre-incubation of the SA-MIPs with SA-derivatives as inhibitors could reduce the binding of the SA-MIPs to the tumor cells, indicating the specificity of the SA-MIPs. In conclusion, the SA-MIPs may be a new powerful tool in the diagnostic analysis of breast cancer cells.

Published
2021

7. JAK3 Is Expressed in the Nucleus of Malignant T Cells in Cutaneous T Cell Lymphoma (CTCL)

Author

Vadivel, Chella Krishna, primary, Gluud, Maria, additional, Torres-Rusillo, Sara, additional, Boding, Lasse, additional, Willerslev-Olsen, Andreas, additional, Buus, Terkild B., additional, Nielsen, Tea Kirkegaard, additional, Persson, Jenny L., additional, Bonefeld, Charlotte M., additional, Geisler, Carsten, additional, Krejsgaard, Thorbjorn, additional, Fuglsang, Anja T., additional, Odum, Niels, additional, and Woetmann, Anders, additional

Published
2021
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8. Establishment of Prostate Tumor Growth and Metastasis Is Supported by Bone Marrow Cells and Is Mediated by PIP5K1α Lipid Kinase

Author

Karlsson, Richard, primary, Larsson, Per, additional, Miftakhova, Regina, additional, Syed Khaja, Azharuddin Sajid, additional, Sarwar, Martuza, additional, Semenas, Julius, additional, Chen, Sa, additional, Hedblom, Andreas, additional, Wang, Tianyan, additional, Ekström-Holka, Kristina, additional, Simoulis, Athanasios, additional, Kumar, Anjani, additional, Ødum, Niels, additional, Grundström, Thomas, additional, and Persson, Jenny L., additional

Published
2020
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9. MicroRNAs in the Pathogenesis, Diagnosis, Prognosis and Targeted Treatment of Cutaneous T-Cell Lymphomas

Author

Gluud, Maria, primary, Willerslev-Olsen, Andreas, additional, Gjerdrum, Lise Mette Rahbek, additional, Lindahl, Lise M., additional, Buus, Terkild B., additional, Andersen, Mads Hald, additional, Bonefeld, Charlotte Menne, additional, Krejsgaard, Thorbjorn, additional, Litvinov, Ivan V., additional, Iversen, Lars, additional, Becker, Jürgen C., additional, Persson, Jenny L., additional, Koralov, Sergei B., additional, Litman, Thomas, additional, Geisler, Carsten, additional, Woetmann, Anders, additional, and Odum, Niels, additional

Published
2020
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