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1. Hypertriglyceridemia: Molecular and Genetic Landscapes

Author

Scicchitano, Pietro, primary, Amati, Francesca, additional, Ciccone, Marco Matteo, additional, D’Ascenzi, Flavio, additional, Imbalzano, Egidio, additional, Liga, Riccardo, additional, Paolillo, Stefania, additional, Pastore, Maria Concetta, additional, Rinaldi, Andrea, additional, Mattioli, Anna Vittoria, additional, and Cameli, Matteo, additional

Published
2024
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2. Myocardial Work Indices Predict Hospitalization in Patients with Advanced Heart Failure

Author

Mandoli, Giulia Elena, primary, Landra, Federico, additional, Chiantini, Benedetta, additional, Bonadiman, Lorenzo, additional, Pastore, Maria Concetta, additional, Focardi, Marta, additional, D’Ascenzi, Flavio, additional, Lisi, Matteo, additional, Diviggiano, Enrico Emilio, additional, Martini, Luca, additional, Bernazzali, Sonia, additional, Valente, Serafina, additional, Maccherini, Massimo, additional, Cameli, Matteo, additional, and Henein, Michael Y., additional

Published
2024
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3. Depression and Anxiety in Pediatric Patients with Beckwith–Wiedemann Syndrome: A Pilot Study

Author

D’Onofrio, Grazia, primary, Mastromatteo, Annalisa, additional, Di Francesco, Andrea, additional, Izzi, Antonio, additional, Marchello, Vincenzo, additional, Manuali, Aldo, additional, Recchia, Andreaserena, additional, Tonti, Maria Pia, additional, Russo, Maria Lazzarina, additional, Affatato, Maria Pia, additional, Rossato, Alessandra, additional, Giuntoli, Cecilia, additional, Palladino, Nicola, additional, Germano, Michele, additional, Pastore, Maria Rosa, additional, and Cassano, Lazzaro, additional

Published
2024
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4. Reverse Septal Movement: A Step Forward in the Comprehension of the Underlying Causes

Author

Diviggiano, Enrico Emilio, primary, Rosi, Sara, additional, Landra, Federico, additional, Marallo, Carmine, additional, Scoppa, Cristina, additional, Castellani, Debora, additional, Mandoli, Giulia Elena, additional, Pastore, Maria Concetta, additional, Cavigli, Luna, additional, D’Ascenzi, Flavio, additional, Cameli, Matteo, additional, and Focardi, Marta, additional

Published
2024
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5. Exercise Stress Echocardiography in Athletes: Applications, Methodology, and Challenges

Author

Palermi, Stefano, primary, Sperlongano, Simona, additional, Mandoli, Giulia Elena, additional, Pastore, Maria Concetta, additional, Lisi, Matteo, additional, Benfari, Giovanni, additional, Ilardi, Federica, additional, Malagoli, Alessandro, additional, Russo, Vincenzo, additional, Ciampi, Quirino, additional, Cameli, Matteo, additional, and D’Andrea, Antonello, additional

Published
2023
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6. Multimodality Imaging in Advanced Heart Failure for Diagnosis, Management and Follow-Up. A Comprehensive Review

Author

Pergola, Valeria, primary, Cameli, Matteo, additional, Mushtaq, Saima, additional, Mattesi, Giulia, additional, D’Andrea, Antonello, additional, Guaricci, Andrea Igoren, additional, Pastore, Maria Concetta, additional, Amato, Filippo, additional, Dellino, Carlo maria, additional, Motta, Raffaella, additional, Perazzolo Marra, Martina, additional, Pedrinelli, Roberto, additional, Dellegrottaglie, Santo, additional, Iliceto, Sabino, additional, Nodari, Savina, additional, Perrone Filardi, Pasquale, additional, and Pontone, Gianluca, additional

Published
2023
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7. Tricuspid Regurgitation Velocity and Mean Pressure Gradient for the Prediction of Pulmonary Hypertension According to the New Hemodynamic Definition

Author

Mandoli, Giulia Elena, primary, Landra, Federico, additional, Chiantini, Benedetta, additional, Sciaccaluga, Carlotta, additional, Pastore, Maria Concetta, additional, Focardi, Marta, additional, Cavigli, Luna, additional, D’Ascenzi, Flavio, additional, Bernazzali, Sonia, additional, Maccherini, Massimo, additional, Valente, Serafina, additional, Cameli, Matteo, additional, and Henein, Michael, additional

Published
2023
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8. ADONHERS (Aged DONor HEart Rescue by Stress Echo) National Protocol: Recipient’s Survival after 10-Year Follow-Up

Author

Mandoli, Giulia Elena, primary, Barilli, Maria, additional, Soviero, Davide, additional, Ghionzoli, Nicolò, additional, Landra, Federico, additional, Maccherini, Massimo, additional, Bernazzali, Sonia, additional, Natali, Benedetta Maria, additional, Focardi, Marta, additional, Cavigli, Luna, additional, D’Ascenzi, Flavio, additional, Pastore, Maria Concetta, additional, Sciaccaluga, Carlotta, additional, Bombardini, Tonino, additional, Valente, Serafina, additional, and Cameli, Matteo, additional

Published
2023
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9. Extracellular Release of Citrullinated Vimentin Directly Acts on Osteoclasts to Promote Bone Resorption in a Mouse Model of Periodontitis

Author

Shindo, Satoru, primary, Pierrelus, Roodelyne, additional, Ikeda, Atsushi, additional, Nakamura, Shin, additional, Heidari, Alireza, additional, Pastore, Maria Rita, additional, Leon, Elizabeth, additional, Ruiz, Sunniva, additional, Chheda, Harsh, additional, Khatiwala, Rhea, additional, Kumagai, Tomoki, additional, Tolson, George, additional, Elderbashy, Islam, additional, Ouhara, Kazuhisa, additional, Han, Xiaozhe, additional, Hernandez, Maria, additional, Vardar-Sengul, Saynur, additional, Shiba, Hideki, additional, and Kawai, Toshihisa, additional

Published
2023
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11. Post-Acute Sequelae of COVID-19: The Potential Role of Exercise Therapy in Treating Patients and Athletes Returning to Play

Author

Cavigli, Luna, primary, Fusi, Chiara, additional, Focardi, Marta, additional, Mandoli, Giulia Elena, additional, Pastore, Maria Concetta, additional, Cameli, Matteo, additional, Valente, Serafina, additional, Zorzi, Alessandro, additional, Bonifazi, Marco, additional, D’Andrea, Antonello, additional, and D’Ascenzi, Flavio, additional

Published
2022
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12. Bedside Ultrasound for Hemodynamic Monitoring in Cardiac Intensive Care Unit

Author

Pastore, Maria Concetta, primary, Ilardi, Federica, additional, Stefanini, Andrea, additional, Mandoli, Giulia Elena, additional, Palermi, Stefano, additional, Bandera, Francesco, additional, Benfari, Giovanni, additional, Esposito, Roberta, additional, Lisi, Matteo, additional, Pasquini, Annalisa, additional, Santoro, Ciro, additional, Valente, Serafina, additional, D’Andrea, Antonello, additional, and Cameli, Matteo, additional

Published
2022
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13. Left Atrial Remodeling in Response to Aortic Valve Replacement: Pathophysiology and Myocardial Strain Analysis

Author

Lisi, Matteo, primary, Pastore, Maria Concetta, additional, Fiorio, Alessio, additional, Cameli, Matteo, additional, Mandoli, Giulia Elena, additional, Righini, Francesca Maria, additional, Cavigli, Luna, additional, D’Ascenzi, Flavio, additional, Focardi, Marta, additional, Rubboli, Andrea, additional, Campo, Gianluca, additional, Mondillo, Sergio, additional, and Henein, Michael Y., additional

Published
2022
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14. Locally Secreted Semaphorin 4D Is Engaged in Both Pathogenic Bone Resorption and Retarded Bone Regeneration in a Ligature-Induced Mouse Model of Periodontitis

Author

Ishii, Takenobu, primary, Ruiz-Torruella, Montserrat, additional, Yamamoto, Kenta, additional, Yamaguchi, Tsuguno, additional, Heidari, Alireza, additional, Pierrelus, Roodelyne, additional, Leon, Elizabeth, additional, Shindo, Satoru, additional, Rawas-Qalaji, Mohamad, additional, Pastore, Maria Rita, additional, Ikeda, Atsushi, additional, Nakamura, Shin, additional, Mawardi, Hani, additional, Kandalam, Umadevi, additional, Hardigan, Patrick, additional, Witek, Lukasz, additional, Coelho, Paulo G., additional, and Kawai, Toshihisa, additional

Published
2022
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15. Dual-Function Semaphorin 4D Released by Platelets: Suppression of Osteoblastogenesis and Promotion of Osteoclastogenesis

Author

Shindo, Satoru, primary, Savitri, Irma Josefina, additional, Ishii, Takenobu, additional, Ikeda, Atsushi, additional, Pierrelus, Roodelyne, additional, Heidari, Alireza, additional, Okubo, Keisuke, additional, Nakamura, Shin, additional, Kandalam, Umadevi, additional, Rawas-Qalaji, Mohamad, additional, Leon, Elizabeth, additional, Pastore, Maria Rita, additional, Hardigan, Patrick, additional, and Kawai, Toshihisa, additional

Published
2022
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17. Biomarkers Predict In-Hospital Major Adverse Cardiac Events in COVID-19 Patients: A Multicenter International Study

Author

Henein, Michael Y., primary, Mandoli, Giulia Elena, additional, Pastore, Maria Concetta, additional, Ghionzoli, Nicolò, additional, Hasson, Fouhad, additional, Nisar, Muhammad K., additional, Islam, Mohammed, additional, Bandera, Francesco, additional, Marrocco-Trischitta, Massimiliano M., additional, Baroni, Irene, additional, Malagoli, Alessandro, additional, Rossi, Luca, additional, Biagi, Andrea, additional, Citro, Rodolfo, additional, Ciccarelli, Michele, additional, Silverio, Angelo, additional, Biagioni, Giulia, additional, Moutiris, Joseph A., additional, Vancheri, Federico, additional, Mazzola, Giovanni, additional, Geraci, Giulio, additional, Thomas, Liza, additional, Altman, Mikhail, additional, Pernow, John, additional, Ahmed, Mona, additional, Santoro, Ciro, additional, Esposito, Roberta, additional, Casas, Guillem, additional, Fernández-Galera, Rubén, additional, Gonzalez, Maribel, additional, Rodriguez Palomares, Jose, additional, Bytyçi, Ibadete, additional, Dini, Frank Lloyd, additional, Cameli, Paolo, additional, Franchi, Federico, additional, Bajraktari, Gani, additional, Badano, Luigi Paolo, additional, and Cameli, Matteo, additional

Published
2021
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19. Cardiac Imaging in Anderson-Fabry Disease: Past, Present and Future

Author

Esposito, Roberta, primary, Santoro, Ciro, additional, Mandoli, Giulia Elena, additional, Cuomo, Vittoria, additional, Sorrentino, Regina, additional, La Mura, Lucia, additional, Pastore, Maria Concetta, additional, Bandera, Francesco, additional, D’Ascenzi, Flavio, additional, Malagoli, Alessandro, additional, Benfari, Giovanni, additional, D’Andrea, Antonello, additional, and Cameli, Matteo, additional

Published
2021
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20. Multicentric Atrial Strain COmparison between Two Different Modalities: MASCOT HIT Study

Author

Cameli, Matteo, primary, Miglioranza, Marcelo Haertel, additional, Magne, Julien, additional, Mandoli, Giulia Elena, additional, Benfari, Giovanni, additional, Ancona, Roberta, additional, Sibilio, Gerolamo, additional, Reskovic Luksic, Vlatka, additional, Dejan, Dosen, additional, Griseli, Leonardo, additional, Van De Heyning, Caroline M., additional, Mortelmans, Philippe, additional, Michalski, Blazej, additional, Kupczynska, Karolina, additional, Di Giannuario, Giovanna, additional, Devito, Fiorella, additional, Dulgheru, Raluca, additional, Ilardi, Federica, additional, Salustri, Alessandro, additional, Abushahba, Galal, additional, Morrone, Doralisa, additional, Fabiani, Iacopo, additional, Penicka, Martin, additional, Katbeh, Asim, additional, Sammarco, Giuseppe, additional, Esposito, Roberta, additional, Santoro, Ciro, additional, Pastore, Maria Concetta, additional, Comenale Pinto, Salvatore, additional, Kalinin, Artem, additional, Pičkure, Žanna, additional, Ažman Juvan, Katja, additional, Zupan Mežnar, Anja, additional, Coisne, Augustine, additional, Coppin, Amandine, additional, Opris, Mihaela Maria, additional, Nistor, Dan Octavian, additional, Paakkanen, Riitta, additional, Biering-Sørensen, Tor, additional, Olsen, Flemming Javier, additional, Lapinskas, Tomas, additional, Vaškelyté, Jolanta Justina, additional, Galian-Gay, Laura, additional, Casas, Guillem, additional, Motoc, Andreea Iulia, additional, Papadopoulos, Constantinos Hristou, additional, Loizos, Savvas, additional, Ágoston, Gergely, additional, Szabó, Istvan, additional, Hristova, Krasimira, additional, Tsonev, Svetlin Netkov, additional, Galli, Elena, additional, Vinereanu, Dragos, additional, Mihaila Baldea, Sorina, additional, Muraru, Denisa, additional, Mondillo, Sergio, additional, Donal, Erwan, additional, Galderisi, Maurizio, additional, Cosyns, Bernard, additional, Edvardsen, Thor, additional, and Popescu, Bogdan A., additional

Published
2020
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21. Surface Pre-Reacted Glass-Ionomer Eluate Suppresses Osteoclastogenesis through Downregulation of the MAPK Signaling Pathway.

Author

Chandra J, Nakamura S, Shindo S, Leon E, Castellon M, Pastore MR, Heidari A, Witek L, Coelho PG, Nakatsuka T, and Kawai T

Abstract

Surface pre-reacted glass-ionomer (S-PRG) is a new bioactive filler utilized for the restoration of decayed teeth by its ability to release six bioactive ions that prevent the adhesion of dental plaque to the tooth surface. Since ionic liquids are reported to facilitate transepithelial penetration, we reasoned that S-PRG applied to root caries could impact the osteoclasts (OCs) in the proximal alveolar bone. Therefore, this study aimed to investigate the effect of S-PRG eluate solution on RANKL-induced OC-genesis and mineral dissolution in vitro. Using RAW264.7 cells as OC precursor cells (OPCs), TRAP staining and pit formation assays were conducted to monitor OC-genesis and mineral dissolution, respectively, while OC-genesis-associated gene expression was measured using quantitative real-time PCR (qPCR). Expression of NFATc1, a master regulator of OC differentiation, and the phosphorylation of MAPK signaling molecules were measured using Western blotting. S-PRG eluate dilutions at 1/200 and 1/400 showed no cytotoxicity to RAW264.7 cells but did significantly suppress both OC-genesis and mineral dissolution. The same concentrations of S-PRG eluate downregulated the RANKL-mediated induction of OCSTAMP and CATK mRNAs, as well as the expression of NFATc1 protein and the phosphorylation of ERK, JNK, and p38. These results demonstrate that S-PRG eluate can downregulate RANKL-induced OC-genesis and mineral dissolution, suggesting that its application to root caries might prevent alveolar bone resorption.

Published
2024
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22. The Role of Speckle Tracking Echocardiography in the Evaluation of Advanced-Heart-Failure Patients.

Author

Martini L, Lisi M, Pastore MC, Righini FM, Rubboli A, Henein MY, and Cameli M

Abstract

Health care is currently showing a fall in heart failure (HF) incidence and prevalence, particularly in developed countries, but with only a subset receiving appropriate therapy to protect the heart against maladaptive processes such as fibrosis and hypertrophy. Appropriate markers of advanced HF remain unidentified, which would help in choosing the most suitable therapy and avoid major compliance problems. Speckle tracking echocardiography (STE) is a good choice, being a non-invasive imaging technique which is able to assess cardiac deformation in a variety of conditions. Several multicenter studies and meta-analyses have demonstrated the clinical application and accuracy of STE in early and late stages of HF, as well as its association with both left ventricular (LV) filling pressures and myocardial oxygen consumption. Furthermore, STE assists in assessing right ventricular free-wall longitudinal strain (RVFWLS), which is a solid predictor of right ventricle failure (RVF) following LV assist device (LVAD) implantation. However, STE is known for its limitations; despite these, it has been shown to explain symptoms and signs and also to be an accurate prognosticator. The aim of this review is to examine the advantages of STE in the early evaluation of myocardial dysfunction and its correlation with right heart catheterization (RHC) parameters, which should have significant clinical relevance in the management of HF patients.

Published
2024
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23. Atrial Fibrillation, Atrial Myopathy, and Thromboembolism: The Additive Value of Echocardiography and Possible New Horizons for Risk Stratification.

Author

Campora A, Lisi M, Pastore MC, Mandoli GE, Ferrari Chen YF, Pasquini A, Rubboli A, Henein MY, and Cameli M

Abstract

Atrial fibrillation (AF) is the most common cardiac sustained arrhythmia, and it is associated with increased stroke and dementia risk. While the established paradigm attributes these complications to blood stasis within the atria and subsequent thrombus formation with cerebral embolization, recent evidence suggests that atrial myopathy (AM) may play a key role. AM is characterized by structural and functional abnormalities of the atria, and can occur with or without AF. Moving beyond classifications based solely on episode duration, the 4S-AF characterization has offered a more comprehensive approach, incorporating patient's stroke risk, symptom severity, AF burden, and substrate assessment (including AM) for tailored treatment decisions. The "ABC" pathway emphasizes anticoagulation, symptom control, and cardiovascular risk modification and emerging evidence suggests broader benefits of early rhythm control strategies, potentially reducing stroke and dementia risk and improving clinical outcomes. However, a better integration of AM assessment into the current framework holds promise for further personalizing AF management and optimizing patient outcomes. This review explores the emerging concept of AM and its potential role as a risk factor for stroke and dementia and in AF patients' management strategies, highlighting the limitations of current risk stratification methods, like the CHA2DS2-VASc score. Echocardiography, particularly left atrial (LA) strain analysis, has shown to be a promising non-invasive tool for AM evaluation and recent studies suggest that LA strain analysis may be a more sensitive risk stratifier for thromboembolic events than AF itself, with some studies showing a stronger association between LA strain and thromboembolic events compared to traditional risk factors. Integrating it into routine clinical practice could improve patient management and targeted therapies for AF and potentially other thromboembolic events. Future studies are needed to explore the efficacy and safety of anticoagulation in AM patients with and without AF and to refine the diagnostic criteria for AM.

Published
2024
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24. Potential Role of Left Atrial Strain to Predict Atrial Fibrillation Recurrence after Catheter Ablation Therapy: A Clinical and Systematic Review.

Author

Barilli M, Mandoli GE, Sisti N, Dokollari A, Ghionzoli N, Soliman-Aboumarie H, D'Ascenzi F, Focardi M, Cavigli L, Pastore MC, and Cameli M

Abstract

Pulmonary vein isolation (PVI) with catheter ablation (CA) represents an effective therapy for atrial fibrillation (AF). Unfortunately, it is still not exempt from severe complications. The balance of risks and benefits should be assessed, and a patient-tailored approach is desirable. So far, several clinical and cardiac imaging parameters have been evaluated to investigate pre- and post-procedural features that could help clinicians in the selection of patients at high risk of a poor outcome after CA. This clinical and systematic review analyses the potential role of new LA parameters, such as LA reservoir strain, to predict AF recurrence after CA therapy. Notably, LA reservoir strain gains substantial clinical importance in patients with paroxysmal AF and when a low CHADS2-VASc score is retrieved. LA reservoir strain provides data concerning the risk of AF recurrence after PVI and, thus, in the management of long-term medical therapy in this patient's group.

Published
2024
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25. Depression and Anxiety in Pediatric Patients with Beckwith-Wiedemann Syndrome: A Pilot Study.

Author

D'Onofrio G, Mastromatteo A, Di Francesco A, Izzi A, Marchello V, Manuali A, Recchia A, Tonti MP, Russo ML, Affatato MP, Rossato A, Giuntoli C, Palladino N, Germano M, Pastore MR, and Cassano L

Abstract

The study's aim was to determine the prevalence of depression and anxiety in children with Beckwith-Wiedemann syndrome (BWS) and their effects on social relationships and family acceptance. The Pediatric Symptom Checklist-35 items (PSC-35), Screen for Child Anxiety Related Emotional Disorders (SCARED), and the Vineland Adaptive Behavior Scale Second Edition (VABS-II) were administered to the children. The parental Acceptance Rejection/Control Questionnaire (PARQ/Control) and Zarit Burden Inventory (ZBI) were administered to parents. In total, 6 patients and 10 parents were included. Patients showed a significant presence of internalizing behavior in PSC-35 (mean, 7.66 ± 3.67), anxiety symptoms (SCARED: mean, 46.33 ± 17.50) and socialization difficulties (mean, 90.83 ± 10.09). Parents reported a perceived good acceptance (mean, 56.33 ± 1.03) and a moderate control (mean, 24.17 ± 1.83), but the burden level was ranked moderate to severe (mean, 59.33 ± 16.78). It was found that the severity of the burden level reported by parents was related to internalizing behavior (OR = 2.000; 95% CI = 0.479-3.521; p = 0.022) and anxiety symptoms (SCARED total score: OR = 3.000; 95% CI = 1.479-4.521; p = 0.005) of children. During psychological counseling in the context of BWS treatment, it is important to identify specific resources that can support patients and families in dealing with stress and identify any critical areas that could hinder the adaptation process.

Published
2024
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26. Multimodality Imaging in Advanced Heart Failure for Diagnosis, Management and Follow-Up: A Comprehensive Review.

Author

Pergola V, Cameli M, Mattesi G, Mushtaq S, D'Andrea A, Guaricci AI, Pastore MC, Amato F, Dellino CM, Motta R, Perazzolo Marra M, Dellegrottaglie S, Pedrinelli R, Iliceto S, Nodari S, Perrone Filardi P, Pontone G, and On Behalf Of The Cluster Imaging Of Italian Society Of Cardiology Sic

Abstract

Advanced heart failure (AHF) presents a complex landscape with challenges spanning diagnosis, management, and patient outcomes. In response, the integration of multimodality imaging techniques has emerged as a pivotal approach. This comprehensive review delves into the profound significance of these imaging strategies within AHF scenarios. Multimodality imaging, encompassing echocardiography, cardiac magnetic resonance imaging (CMR), nuclear imaging and cardiac computed tomography (CCT), stands as a cornerstone in the care of patients with both short- and long-term mechanical support devices. These techniques facilitate precise device selection, placement, and vigilant monitoring, ensuring patient safety and optimal device functionality. In the context of orthotopic cardiac transplant (OTC), the role of multimodality imaging remains indispensable. Echocardiography offers invaluable insights into allograft function and potential complications. Advanced methods, like speckle tracking echocardiography (STE), empower the detection of acute cell rejection. Nuclear imaging, CMR and CCT further enhance diagnostic precision, especially concerning allograft rejection and cardiac allograft vasculopathy. This comprehensive imaging approach goes beyond diagnosis, shaping treatment strategies and risk assessment. By harmonizing diverse imaging modalities, clinicians gain a panoramic understanding of each patient's unique condition, facilitating well-informed decisions. The aim is to highlight the novelty and unique aspects of recently published papers in the field. Thus, this review underscores the irreplaceable role of multimodality imaging in elevating patient outcomes, refining treatment precision, and propelling advancements in the evolving landscape of advanced heart failure management.

Published
2023
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