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1. Ischemia–Reperfusion Injury in Kidney Transplantation: Mechanisms and Potential Therapeutic Targets

Author

Lasorsa, Francesco, primary, Rutigliano, Monica, additional, Milella, Martina, additional, d’Amati, Antonio, additional, Crocetto, Felice, additional, Pandolfo, Savio Domenico, additional, Barone, Biagio, additional, Ferro, Matteo, additional, Spilotros, Marco, additional, Battaglia, Michele, additional, Ditonno, Pasquale, additional, and Lucarelli, Giuseppe, additional

Published
2024
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2. Testicular Cancer Treatments and Sexuality: A Narrative Review

Author

Raffo, Massimiliano, primary, Di Naro, Angelo, additional, Napolitano, Luigi, additional, Aveta, Achille, additional, Cilio, Simone, additional, Pandolfo, Savio Domenico, additional, Manfredi, Celeste, additional, Lonati, Chiara, additional, and Suardi, Nazareno Roberto, additional

Published
2024
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3. Tissue-Based Genomic Testing in Prostate Cancer: 10-Year Analysis of National Trends on the Use of Prolaris, Decipher, ProMark, and Oncotype DX

Author

Bologna, Eugenio, primary, Ditonno, Francesco, additional, Licari, Leslie Claire, additional, Franco, Antonio, additional, Manfredi, Celeste, additional, Mossack, Spencer, additional, Pandolfo, Savio Domenico, additional, De Nunzio, Cosimo, additional, Simone, Giuseppe, additional, Leonardo, Costantino, additional, and Franco, Giorgio, additional

Published
2024
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4. Outcomes and Techniques of Robotic-Assisted Partial Nephrectomy (RAPN) for Renal Hilar Masses: A Comprehensive Systematic Review

Author

Pandolfo, Savio Domenico, primary, Wu, Zhenjie, additional, Campi, Riccardo, additional, Bertolo, Riccardo, additional, Amparore, Daniele, additional, Mari, Andrea, additional, Verze, Paolo, additional, Manfredi, Celeste, additional, Franco, Antonio, additional, Ditonno, Francesco, additional, Cerrato, Clara, additional, Ferro, Matteo, additional, Lasorsa, Francesco, additional, Contieri, Roberto, additional, Napolitano, Luigi, additional, Tufano, Antonio, additional, Lucarelli, Giuseppe, additional, Cilio, Simone, additional, Perdonà, Sisto, additional, Siracusano, Salvatore, additional, Autorino, Riccardo, additional, and Aveta, Achille, additional

Published
2024
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5. Carbapenem-Resistant Enterobacteriaceae in Urinary Tract Infections: From Biological Insights to Emerging Therapeutic Alternatives

Author

Bologna, Eugenio, primary, Licari, Leslie Claire, additional, Manfredi, Celeste, additional, Ditonno, Francesco, additional, Cirillo, Luigi, additional, Fusco, Giovanni Maria, additional, Abate, Marco, additional, Passaro, Francesco, additional, Di Mauro, Ernesto, additional, Crocetto, Felice, additional, Pandolfo, Savio Domenico, additional, Aveta, Achille, additional, Cilio, Simone, additional, Di Filippo, Isabella, additional, Barone, Biagio, additional, Franco, Antonio, additional, Arcaniolo, Davide, additional, La Rocca, Roberto, additional, Pinchera, Biagio, additional, and Napolitano, Luigi, additional

Published
2024
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6. Complement System and the Kidney: Its Role in Renal Diseases, Kidney Transplantation and Renal Cell Carcinoma

Author

Lasorsa, Francesco, primary, Rutigliano, Monica, additional, Milella, Martina, additional, Ferro, Matteo, additional, Pandolfo, Savio Domenico, additional, Crocetto, Felice, additional, Simone, Simona, additional, Gesualdo, Loreto, additional, Battaglia, Michele, additional, Ditonno, Pasquale, additional, and Lucarelli, Giuseppe, additional

Published
2023
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7. The Role of miRNA in Testicular Cancer: Current Insights and Future Perspectives

Author

Ditonno, Francesco, primary, Franco, Antonio, additional, Manfredi, Celeste, additional, Fasanella, Daniela, additional, Abate, Marco, additional, La Rocca, Roberto, additional, Crocerossa, Fabio, additional, Iossa, Vincenzo, additional, Falagario, Ugo Giovanni, additional, Cirillo, Luigi, additional, Altieri, Vincenzo Maria, additional, Di Mauro, Ernesto, additional, Crocetto, Felice, additional, Barone, Biagio, additional, Cilio, Simone, additional, Pandolfo, Savio Domenico, additional, Aveta, Achille, additional, Mirone, Vincenzo, additional, Franzese, Corrado Aniello, additional, Arcaniolo, Davide, additional, and Napolitano, Luigi, additional

Published
2023
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8. Cancer Stem Cells in Renal Cell Carcinoma: Origins and Biomarkers

Author

Lasorsa, Francesco, primary, Rutigliano, Monica, additional, Milella, Martina, additional, Ferro, Matteo, additional, Pandolfo, Savio Domenico, additional, Crocetto, Felice, additional, Autorino, Riccardo, additional, Battaglia, Michele, additional, Ditonno, Pasquale, additional, and Lucarelli, Giuseppe, additional

Published
2023
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9. Urinary MicroRNAs as Biomarkers of Urological Cancers: A Systematic Review

Author

Aveta, Achille, primary, Cilio, Simone, additional, Contieri, Roberto, additional, Spena, Gianluca, additional, Napolitano, Luigi, additional, Manfredi, Celeste, additional, Franco, Antonio, additional, Crocerossa, Fabio, additional, Cerrato, Clara, additional, Ferro, Matteo, additional, Del Giudice, Francesco, additional, Verze, Paolo, additional, Lasorsa, Francesco, additional, Salonia, Andrea, additional, Nair, Rajesh, additional, Walz, Jochen, additional, Lucarelli, Giuseppe, additional, and Pandolfo, Savio Domenico, additional

Published
2023
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11. Urinary Micro-RNAs As Biomarkers of Urological Cancers: A Systematic Review

Author

Aveta, Achille, primary, Cilio, Simone, additional, Contieri, Roberto, additional, Spena, Gianluca, additional, Napolitano, Luigi, additional, Manfredi, Celeste, additional, Franco, Antonio, additional, Crocerossa, Fabio, additional, Cerrato, Clara, additional, Ferro, Matteo, additional, Del Giudice, Francesco Paolo, additional, Verze, Paolo, additional, Lasorsa, Francesco, additional, Salonia, Andrea, additional, Nair, Rajesh, additional, Walz, Jochen, additional, Lucarelli, Giuseppe, additional, and Pandolfo, Savio Domenico, additional

Published
2023
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12. Cytoreductive Nephrectomy and Metastatic Renal Cell Carcinoma: State of the Art and Future Perspectives

Author

Napolitano, Luigi, primary, Manfredi, Celeste, additional, Cirillo, Luigi, additional, Fusco, Giovanni Maria, additional, Passaro, Francesco, additional, Abate, Marco, additional, La Rocca, Roberto, additional, Mastrangelo, Francesco, additional, Spirito, Lorenzo, additional, Pandolfo, Savio Domenico, additional, Crocetto, Felice, additional, Arcaniolo, Davide, additional, and Barone, Biagio, additional

Published
2023
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13. The Efficacy of Flogofilm® in the Treatment of Chronic Bacterial Prostatitis as an Adjuvant to Antibiotic Therapy: A Randomized Prospective Trial

Author

Barone, Biagio, primary, Mirto, Benito Fabio, additional, Falcone, Alfonso, additional, Del Giudice, Francesco, additional, Aveta, Achille, additional, Napolitano, Luigi, additional, Del Biondo, Dario, additional, Ferro, Matteo, additional, Busetto, Gian Maria, additional, Manfredi, Celeste, additional, Terracciano, Daniela, additional, Gambardella, Raffaele, additional, Pandolfo, Savio Domenico, additional, Trama, Francesco, additional, De Luca, Ciro, additional, Martino, Raffaele, additional, Capone, Federico, additional, Giampaglia, Gaetano, additional, Sicignano, Enrico, additional, Tataru, Octavian Sabin, additional, Lucarelli, Giuseppe, additional, and Crocetto, Felice, additional

Published
2023
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14. A Novel Low-Cost Uroflowmetry for Patient Telemonitoring

Author

Pandolfo, Savio Domenico, primary, Crauso, Federica, additional, Aveta, Achille, additional, Cilio, Simone, additional, Barone, Biagio, additional, Napolitano, Luigi, additional, Scarpato, Antonio, additional, Mirto, Benito Fabio, additional, Serino, Francesco, additional, Del Giudice, Francesco, additional, Chung, Benjamin I., additional, Crocerossa, Fabio, additional, Di Zazzo, Erika, additional, Trama, Francesco, additional, Vaglio, Ruggero, additional, Wu, Zhenjie, additional, Verze, Paolo, additional, Imbimbo, Ciro, additional, and Crocetto, Felice, additional

Published
2023
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15. Voice Assistants as Consultants for Male Patients with Sexual Dysfunction: A Reliable Option?

Author

Napolitano, Luigi, primary, Barone, Biagio, additional, Spirito, Lorenzo, additional, Trama, Francesco, additional, Pandolfo, Savio Domenico, additional, Capece, Marco, additional, García-Rojo, Esther, additional, Fernández-Pascual, Esaú, additional, Crocetto, Felice, additional, Fusco, Ferdinando, additional, De Sio, Marco, additional, Arcaniolo, Davide, additional, and Manfredi, Celeste, additional

Published
2023
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16. Renal Cell Carcinoma as a Metabolic Disease: An Update on Main Pathways, Potential Biomarkers, and Therapeutic Targets

Author

di Meo, Nicola Antonio, primary, Lasorsa, Francesco, additional, Rutigliano, Monica, additional, Loizzo, Davide, additional, Ferro, Matteo, additional, Stella, Alessandro, additional, Bizzoca, Cinzia, additional, Vincenti, Leonardo, additional, Pandolfo, Savio Domenico, additional, Autorino, Riccardo, additional, Crocetto, Felice, additional, Montanari, Emanuele, additional, Spilotros, Marco, additional, Battaglia, Michele, additional, Ditonno, Pasquale, additional, and Lucarelli, Giuseppe, additional

Published
2022
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17. Micro-Ultrasound in the Diagnosis and Staging of Prostate and Bladder Cancer: A Comprehensive Review

Author

Calace, Francesco Paolo, primary, Napolitano, Luigi, additional, Arcaniolo, Davide, additional, Stizzo, Marco, additional, Barone, Biagio, additional, Crocetto, Felice, additional, Olivetta, Michelangelo, additional, Amicuzi, Ugo, additional, Cirillo, Luigi, additional, Rubinacci, Andrea, additional, Lecce, Arturo, additional, Pandolfo, Savio Domenico, additional, Langella, Nunzio Alberto, additional, Persico, Francesco, additional, Trama, Francesco, additional, Quattrone, Carmelo, additional, Bottone, Francesco, additional, Spirito, Lorenzo, additional, De Sio, Marco, additional, and Manfredi, Celeste, additional

Published
2022
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18. Characteristics of Sepsis or Acute Pyelonephritis Combined with Ureteral Stone in the United States: A Retrospective Analysis of Large National Cohort

Author

Del Giudice, Francesco, primary, Yoo, Koo Han, additional, Lee, Sinyeong, additional, Oh, Jin Kyu, additional, Cho, Hyuk Jin, additional, Kim, Sang Youn, additional, Min, Gyeong Eun, additional, Lee, Sang Hyub, additional, Kim, Wansuk, additional, Li, Shufeng, additional, Wei, Wuran, additional, Huang, Jianlin, additional, Brown, David R., additional, Spradling, Kyle, additional, Basran, Satvir, additional, Belladelli, Federico, additional, Autorino, Riccardo, additional, Pandolfo, Savio Domenico, additional, Crivellaro, Simone, additional, Crocetto, Felice, additional, Ferro, Matteo, additional, Asero, Vincenzo, additional, Scornajenghi, Carlo Maria, additional, Bologna, Eugenio, additional, Sciarra, Alessandro, additional, Salciccia, Stefano, additional, De Berardinis, Ettore, additional, Ricciuti, Gian Piero, additional, van Uem, Stefanie, additional, Conti, Simon, additional, and Chung, Benjamin I., additional

Published
2022
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20. The Impact of Meat Intake on Bladder Cancer Incidence: Is It Really a Relevant Risk?

Author

Aveta, Achille, primary, Cacciapuoti, Crescenzo, additional, Barone, Biagio, additional, Di Zazzo, Erika, additional, Del Giudice, Francesco, additional, Maggi, Martina, additional, Ferro, Matteo, additional, Terracciano, Daniela, additional, Busetto, Gian Maria, additional, Lucarelli, Giuseppe, additional, Tataru, Octavian Sabin, additional, Montanari, Emanuele, additional, Mirto, Benito Fabio, additional, Falcone, Alfonso, additional, Giampaglia, Gaetano, additional, Sicignano, Enrico, additional, Capone, Federico, additional, Villano, Gianluca, additional, Angellotto, Pasquale, additional, Manfredi, Celeste, additional, Napolitano, Luigi, additional, Imbimbo, Ciro, additional, Pandolfo, Savio Domenico, additional, and Crocetto, Felice, additional

Published
2022
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21. Recent Trends in the Diagnostic and Surgical Management of Benign Prostatic Hyperplasia in the U.S. from 2004 to 2017: Annual Changes in the Selection of Treatment Options and Medical Costs

Author

Del Giudice, Francesco, primary, Oh, Jin Kyu, additional, Basran, Satvir, additional, Nicaise, Edouard, additional, Song, Phil Hyun, additional, Kim, Wansuk, additional, Kim, Sang Youn, additional, Min, Gyeong Eun, additional, Yoo, Koo Han, additional, Cho, Hyuk Jin, additional, Lee, Sinyeong, additional, Sciarra, Alessandro, additional, Salciccia, Stefano, additional, De Berardinis, Ettore, additional, Asero, Vincenzo, additional, Scornajenghi, Carlo Maria, additional, Pradere, Benjamin, additional, Krajewski, Wojciech, additional, Gallioli, Andrea, additional, Ferro, Matteo, additional, Crocetto, Felice, additional, Pandolfo, Savio Domenico, additional, Autorino, Riccardo, additional, Belladelli, Federico, additional, Mari, Andrea, additional, Busetto, Gian Maria, additional, Li, Shufeng, additional, Crivellaro, Simone, additional, and Chung, Benjamin Inbeh, additional

Published
2022
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22. Metabolomic Approaches for Detection and Identification of Biomarkers and Altered Pathways in Bladder Cancer

Author

di Meo, Nicola Antonio, primary, Loizzo, Davide, additional, Pandolfo, Savio Domenico, additional, Autorino, Riccardo, additional, Ferro, Matteo, additional, Porta, Camillo, additional, Stella, Alessandro, additional, Bizzoca, Cinzia, additional, Vincenti, Leonardo, additional, Crocetto, Felice, additional, Tataru, Octavian Sabin, additional, Rutigliano, Monica, additional, Battaglia, Michele, additional, Ditonno, Pasquale, additional, and Lucarelli, Giuseppe, additional

Published
2022
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23. Novel Insights into Autophagy and Prostate Cancer: A Comprehensive Review

Author

Loizzo, Davide, primary, Pandolfo, Savio Domenico, additional, Rogers, Devin, additional, Cerrato, Clara, additional, di Meo, Nicola Antonio, additional, Autorino, Riccardo, additional, Mirone, Vincenzo, additional, Ferro, Matteo, additional, Porta, Camillo, additional, Stella, Alessandro, additional, Bizzoca, Cinzia, additional, Vincenti, Leonardo, additional, Spilotros, Marco, additional, Rutigliano, Monica, additional, Battaglia, Michele, additional, Ditonno, Pasquale, additional, and Lucarelli, Giuseppe, additional

Published
2022
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24. The Role of Testosterone in the Elderly: What Do We Know?

Author

Barone, Biagio, primary, Napolitano, Luigi, additional, Abate, Marco, additional, Cirillo, Luigi, additional, Reccia, Pasquale, additional, Passaro, Francesco, additional, Turco, Carmine, additional, Morra, Simone, additional, Mastrangelo, Francesco, additional, Scarpato, Antonio, additional, Amicuzi, Ugo, additional, Morgera, Vincenzo, additional, Romano, Lorenzo, additional, Calace, Francesco Paolo, additional, Pandolfo, Savio Domenico, additional, De Luca, Luigi, additional, Aveta, Achille, additional, Sicignano, Enrico, additional, Trivellato, Massimiliano, additional, Spena, Gianluca, additional, D’Alterio, Carlo, additional, Fusco, Giovanni Maria, additional, Vitale, Raffaele, additional, Arcaniolo, Davide, additional, and Crocetto, Felice, additional

Published
2022
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25. A Comparative Study of the Triglycerides/HDL Ratio and Pseudocholinesterase Levels in Patients with Bladder Cancer

Author

Crocetto, Felice, primary, Pandolfo, Savio Domenico, additional, Aveta, Achille, additional, Martino, Raffaele, additional, Trama, Francesco, additional, Caputo, Vincenzo Francesco, additional, Barone, Biagio, additional, Abate, Marco, additional, Sicignano, Enrico, additional, Cilio, Simone, additional, Russo, Gianluca, additional, Massanova, Matteo, additional, Di Vito, Concetta, additional, Imbimbo, Ciro, additional, and Tarantino, Giovanni, additional

Published
2022
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26. Kaempferol, Myricetin and Fisetin in Prostate and Bladder Cancer: A Systematic Review of the Literature

Author

Crocetto, Felice, primary, di Zazzo, Erika, additional, Buonerba, Carlo, additional, Aveta, Achille, additional, Pandolfo, Savio Domenico, additional, Barone, Biagio, additional, Trama, Francesco, additional, Caputo, Vincenzo Francesco, additional, Scafuri, Luca, additional, Ferro, Matteo, additional, Cosimato, Vincenzo, additional, Fusco, Ferdinando, additional, Imbimbo, Ciro, additional, and Di Lorenzo, Giuseppe, additional

Published
2021
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29. The Efficacy of Flogofilm® in the Treatment of Chronic Bacterial Prostatitis as an Adjuvant to Antibiotic Therapy: A Randomized Prospective Trial

Author

Biagio Barone, Benito Fabio Mirto, Alfonso Falcone, Francesco Del Giudice, Achille Aveta, Luigi Napolitano, Dario Del Biondo, Matteo Ferro, Gian Maria Busetto, Celeste Manfredi, Daniela Terracciano, Raffaele Gambardella, Savio Domenico Pandolfo, Francesco Trama, Ciro De Luca, Raffaele Martino, Federico Capone, Gaetano Giampaglia, Enrico Sicignano, Octavian Sabin Tataru, Giuseppe Lucarelli, Felice Crocetto, Barone, Biagio, Mirto, Benito Fabio, Falcone, Alfonso, Del Giudice, Francesco, Aveta, Achille, Napolitano, Luigi, Del Biondo, Dario, Ferro, Matteo, Busetto, Gian Maria, Manfredi, Celeste, Terracciano, Daniela, Gambardella, Raffaele, Pandolfo, Savio Domenico, Trama, Francesco, De Luca, Ciro, Martino, Raffaele, Capone, Federico, Giampaglia, Gaetano, Sicignano, Enrico, Tataru, Octavian Sabin, Lucarelli, Giuseppe, and Crocetto, Felice

Subjects
chronic prostatitis, fluoroquinolones, NIH-CPSI, IPSS, Flogofilm®, General Medicine, chronic prostatiti
Abstract

Introduction: Bacterial prostatitis (BP) is a common prostatic infection characterized by a bimodal distribution in young and older men, with a prevalence between 5–10% among all cases of prostatitis and a high impact on quality of life. Although the management of bacterial prostatitis involves the use of appropriate spectrum antibiotics, which represent the first choice of treatment, a multimodal approach encompassing antibiotics and nutraceutical products in order to improve the efficacy of chosen antimicrobial regimen is often required. Objective: To evaluate the efficacy of Flogofilm® in association with fluoroquinolones in patients with chronic bacterial prostatitis (CBP). Methods: Patients diagnosed with prostatitis (positivity to Meares–Stamey Test and symptoms duration > 3 months) at the University of Naples “Federico II”, Italy, from July 2021 to December 2021, were included in this study. All patients underwent bacterial cultures and trans-rectal ultrasounds. Patients were randomized into two groups (A and B) receiving antibiotic alone or an association of antibiotics plus Flogofilm® tablets containing Flogomicina® for one month, respectively. The NIH-CPSI and IPSS questionnaires were administered at baseline, four weeks, twelve and twenty-four weeks. Results: A total of 96 (Group A = 47, Group B = 49) patients concluded the study protocol. The mean age was comparable, with a mean age of 34.62 ± 9.04 years for Group A and 35.29 ± 10.32 years for Group B (p = 0.755), and IPSS at the baseline was 8.28 ± 6.33 and 9.88 ± 6.89 (p = 0.256), respectively, while NIH-CPSI at baseline was 21.70 ± 4.38 and 21.67 ± 6.06 (p = 0.959), respectively. At 1, 3 and 6 months, the IPSS score was 6.45 ± 4.8 versus 4.31 ± 4.35 (p = 0.020), 5.32 ± 4.63 versus 3.20 ± 3.05 (p = 0.042) and 4.91 ± 4.47 versus 2.63 ± 3.28 (p = 0.005) for Groups A and B, respectively. Similarly, the NIH-CPSI total score at 1, 3 and 6 months was 16.15 ± 3.31 versus 13.10 ± 5.03 (p < 0.0001), 13.47 ± 3.07 versus 9.65 ± 4.23 (p < 0.0001) and 9.83 ± 2.53 versus 5.51 ± 2.84 (p < 0.0001), respectively. Conclusions: Flogofilm®, associated with fluoroquinolones, demonstrate a significant improvement in pain, urinary symptoms and quality of life in patients affected by chronic bacterial prostatitis in both IPSS and NIH-CPSI scores compared with fluoroquinolones alone.

Published
2023

30. Voice Assistants as Consultants for Male Patients with Sexual Dysfunction: A Reliable Option?

Author

Luigi Napolitano, Biagio Barone, Lorenzo Spirito, Francesco Trama, Savio Domenico Pandolfo, Marco Capece, Esther García-Rojo, Esaú Fernández-Pascual, Felice Crocetto, Ferdinando Fusco, Marco De Sio, Davide Arcaniolo, Celeste Manfredi, Napolitano, Luigi, Barone, Biagio, Spirito, Lorenzo, Trama, Francesco, Pandolfo, Savio Domenico, Capece, Marco, García-Rojo, Esther, Fernández-Pascual, Esaú, Crocetto, Felice, Fusco, Ferdinando, De Sio, Marco, Arcaniolo, Davide, and Manfredi, Celeste

Subjects
Google Assistant, Health, Toxicology and Mutagenesis, sexual health, voice assistant, Public Health, Environmental and Occupational Health, Alexa, Siri
Abstract

The aim of this study was to evaluate the ability of Google Assistant, Alexa, and Siri to recognize and answer questions about male sexual health. Each VA was tested on a smart speaker: Alexa on Amazon Echo Dot 4th Gen., Google Assistant on Google Home Mini, and Siri on Apple HomePod. A pool of patients’ frequently asked questions regarding erectile dysfunction (ED), premature ejaculation (PE), Peyronie’s disease (PD), male infertility, and other aspects of male sexual health were identified by authors. The recognition of question was evaluated (“yes” or “not”). For each recognized question, the response characteristics (domains) were rated on a scale from 0 to 10 (according to the quality). We chose the recognition rate of the questions as the primary outcome and the quality of the answers as the secondary outcome. Overall, the best VA in recognizing questions was Siri, with a total of 83.3% questions compared with 64.0% for Alexa (p = 0.024) and 74.0% for Google Assistant (p = 0.061). Siri was associated with a significantly higher recognition rate than Alexa for PE (80% vs. 40%; p = 0.002) and PD (66.7% vs. 33.3%; p = 0.010). The quality of the responses was classified as low in 57 out of 105 cases (54.3%), intermediate in 46 cases (43.8%), and high in only 2 cases (1.9%), highlighting an overall intermediate-low quality of the answers. Male infertility was the condition associated with the highest mean scores in “Targeted response to the problem” (7.32 ± 2.57), “Scientific correctness of the answer”, (5.9 ± 2.76) “Completeness of the answer” (5.14 ± 2.56), and “Understandability of the response for a patient” (5.3 ± 2.51) domains. Siri was associated with significantly higher scores than Alexa (p < 0.05) in several domains of all conditions evaluated. The question recognition rate of VAs is quite high; however, the quality of the answers is still intermediate-low. Siri seems superior to Alexa in both question recognition and response quality. Male infertility appears to be the sexual dysfunction best addressed by VAs.

Published
2023

31. Renal Cell Carcinoma as a Metabolic Disease: An Update on Main Pathways, Potential Biomarkers, and Therapeutic Targets

Author

Nicola Antonio di Meo, Francesco Lasorsa, Monica Rutigliano, Davide Loizzo, Matteo Ferro, Alessandro Stella, Cinzia Bizzoca, Leonardo Vincenti, Savio Domenico Pandolfo, Riccardo Autorino, Felice Crocetto, Emanuele Montanari, Marco Spilotros, Michele Battaglia, Pasquale Ditonno, Giuseppe Lucarelli, di Meo, Nicola Antonio, Lasorsa, Francesco, Rutigliano, Monica, Loizzo, Davide, Ferro, Matteo, Stella, Alessandro, Bizzoca, Cinzia, Vincenti, Leonardo, Pandolfo, Savio Domenico, Autorino, Riccardo, Crocetto, Felice, Montanari, Emanuele, Spilotros, Marco, Battaglia, Michele, Ditonno, Pasquale, and Lucarelli, Giuseppe

Subjects
Warburg effect, biomarker, metabolism, metabolomics, renal cell carcinoma, Organic Chemistry, General Medicine, Kidney Neoplasms, Catalysis, Settore MED/24 - Urologia, Computer Science Applications, Inorganic Chemistry, Metabolic Diseases, Humans, Metabolomics, Physical and Theoretical Chemistry, Carcinoma, Renal Cell, Molecular Biology, Biomarkers, Spectroscopy, metabolomic
Abstract

Clear cell renal cell carcinoma (ccRCC) is the most frequent histological kidney cancer subtype. Over the last decade, significant progress has been made in identifying the genetic and metabolic alterations driving ccRCC development. In particular, an integrated approach using transcriptomics, metabolomics, and lipidomics has led to a better understanding of ccRCC as a metabolic disease. The metabolic profiling of this cancer could help define and predict its behavior in terms of aggressiveness, prognosis, and therapeutic responsiveness, and would be an innovative strategy for choosing the optimal therapy for a specific patient. This review article describes the current state-of-the-art in research on ccRCC metabolic pathways and potential therapeutic applications. In addition, the clinical implication of pharmacometabolomic intervention is analyzed, which represents a new field for novel stage-related and patient-tailored strategies according to the specific susceptibility to new classes of drugs.

Published
2022

32. Insights into Porphyromonas somerae in Bladder Cancer Patients: Urinary Detection by ddPCR.

Author

Russo F, Esposito S, Tripodi L, Pandolfo SD, Aveta A, Amato F, Nardelli C, Imbimbo C, Pastore L, and Castaldo G

Abstract

To date, the increased awareness of the impact of microbes on human health has promoted scientific interest in microbiome studies for diagnostic and therapeutic purposes, revealing correlations between specific taxa and cancer. In particular, numerous species of Porphyromonas have been associated with several types of tumors. Previously, we studied the urobiome using Next-Generation Sequencing (NGS), and found an increase in Porphyromonas somerae in first morning urine of subjects affected by bladder cancer (BCa). Here, we aimed to confirm the presence of P. somerae in BCa patients by using droplet digital Polymerase Chain Reaction (ddPCR), testing a cohort of 102 male subjects over 50 years. Our findings showed a significant increase in P. somerae in the urine of the BCa group within both ddPCR and NGS, and a correlation between the two methods was observed at a statistical level. Moreover, P. somerae's identification with ddPCR confirmed a significant association between this bacterium and the presence of BCa, highlighting its potential role as a biomarker. This allows us to propose the ddPCR as a suitable method for first-stage BCa screening and follow-up.

Published
2024
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33. Comparison of Current International Guidelines on Premature Ejaculation: 2024 Update.

Author

Romano L, Arcaniolo D, Spirito L, Quattrone C, Bottone F, Pandolfo SD, Barone B, Napolitano L, Ditonno F, Franco A, Crocetto F, Romero-Otero J, Autorino R, De Sio M, and Manfredi C

Abstract

Premature ejaculation (PE) is a common male sexual dysfunction that can cause significant distress in the patient and partner. This study aimed to compare the current international guidelines on PE to highlight their similarities and differences. We examined the latest guidelines from the European Association of Urology (EAU), American Urological Association/Sexual Medicine Society of North America (AUA/SMSNA), and International Society of Sexual Medicine (ISSM) by comparing definitions, classifications, epidemiology, pathophysiology, and recommendations on diagnosis and therapy. The quality of guidelines was assessed using the Appraisal of Guidelines for Research and Evaluation (AGREE) Global Rating Scale (GRS). We found significant variations in the definitions of PE and recommendations on management of patients. The EAU guidelines were the most recent, the AUA/SMSNA guidelines lacked detail in some areas, and the ISSM guidelines were the most complete but also the least updated. The search for a unified definition and the development of standardized diagnostic and therapeutic pathways remain concrete issues to improve the management of patients with PE worldwide.

Published
2024
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34. Ablative Treatments for Small Renal Masses and Management of Recurrences: A Comprehensive Review.

Author

Aveta A, Iossa V, Spena G, Conforti P, Pagano G, Dinacci F, Verze P, Manfredi C, Ferro M, Lasorsa F, Spirito L, Napolitano L, Tufano A, Fiorenza A, Russo P, Crocerossa F, Lucarelli G, Perdonà S, Sanseverino R, Siracusano S, Cilio S, and Pandolfo SD

Abstract

This review focuses on ablative techniques for small renal masses (SRMs), including radiofrequency ablation (RFA), cryoablation (CA), microwave ablation (MWA), and irreversible electroporation (IRE), and discusses recurrence management. Through an extensive literature review, we outline the procedures, outcomes, and follow-up strategies associated with each ablative method. The review provides a detailed examination of these techniques-RFA, CA, MWA, and IRE-elucidating their respective outcomes. Recurrence rates vary among them, with RFA and CA showing comparable rates, MWA demonstrating favorable short-term results, and IRE exhibiting promise in experimental stages. For managing recurrences, various strategies are considered, including active surveillance, re-ablation, or salvage surgery. Surveillance is preferred post-RFA and post-CA, due to slow SRM growth, while re-ablation, particularly with RFA and CA, is deemed feasible without additional complications. Salvage surgery emerges as a viable option for larger or resistant tumors. While ablative techniques offer short-term results comparable to surgery, further research is essential to understand their long-term effects fully. Decisions concerning recurrence management should consider individual and tumor-specific factors. Imaging, notably contrast-enhanced ultrasounds, plays a pivotal role in assessing treatment success, emphasizing the necessity of a multidisciplinary approach for optimal outcomes. The lack of randomized trials highlights the need for further research.

Published
2024
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35. The Efficacy of Flogofilm ® in the Treatment of Chronic Bacterial Prostatitis as an Adjuvant to Antibiotic Therapy: A Randomized Prospective Trial.

Author

Barone B, Mirto BF, Falcone A, Del Giudice F, Aveta A, Napolitano L, Del Biondo D, Ferro M, Busetto GM, Manfredi C, Terracciano D, Gambardella R, Pandolfo SD, Trama F, De Luca C, Martino R, Capone F, Giampaglia G, Sicignano E, Tataru OS, Lucarelli G, and Crocetto F

Abstract

Introduction: Bacterial prostatitis (BP) is a common prostatic infection characterized by a bimodal distribution in young and older men, with a prevalence between 5-10% among all cases of prostatitis and a high impact on quality of life. Although the management of bacterial prostatitis involves the use of appropriate spectrum antibiotics, which represent the first choice of treatment, a multimodal approach encompassing antibiotics and nutraceutical products in order to improve the efficacy of chosen antimicrobial regimen is often required., Objective: To evaluate the efficacy of Flogofilm ® in association with fluoroquinolones in patients with chronic bacterial prostatitis (CBP)., Methods: Patients diagnosed with prostatitis (positivity to Meares-Stamey Test and symptoms duration > 3 months) at the University of Naples "Federico II", Italy, from July 2021 to December 2021, were included in this study. All patients underwent bacterial cultures and trans-rectal ultrasounds. Patients were randomized into two groups (A and B) receiving antibiotic alone or an association of antibiotics plus Flogofilm ® tablets containing Flogomicina ® for one month, respectively. The NIH-CPSI and IPSS questionnaires were administered at baseline, four weeks, twelve and twenty-four weeks., Results: A total of 96 (Group A = 47, Group B = 49) patients concluded the study protocol. The mean age was comparable, with a mean age of 34.62 ± 9.04 years for Group A and 35.29 ± 10.32 years for Group B ( p = 0.755), and IPSS at the baseline was 8.28 ± 6.33 and 9.88 ± 6.89 ( p = 0.256), respectively, while NIH-CPSI at baseline was 21.70 ± 4.38 and 21.67 ± 6.06 ( p = 0.959), respectively. At 1, 3 and 6 months, the IPSS score was 6.45 ± 4.8 versus 4.31 ± 4.35 ( p = 0.020), 5.32 ± 4.63 versus 3.20 ± 3.05 ( p = 0.042) and 4.91 ± 4.47 versus 2.63 ± 3.28 ( p = 0.005) for Groups A and B, respectively. Similarly, the NIH-CPSI total score at 1, 3 and 6 months was 16.15 ± 3.31 versus 13.10 ± 5.03 ( p < 0.0001), 13.47 ± 3.07 versus 9.65 ± 4.23 ( p < 0.0001) and 9.83 ± 2.53 versus 5.51 ± 2.84 ( p < 0.0001), respectively., Conclusions: Flogofilm ® , associated with fluoroquinolones, demonstrate a significant improvement in pain, urinary symptoms and quality of life in patients affected by chronic bacterial prostatitis in both IPSS and NIH-CPSI scores compared with fluoroquinolones alone.

Published
2023
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36. Immune Checkpoint Inhibitors in Renal Cell Carcinoma: Molecular Basis and Rationale for Their Use in Clinical Practice.

Author

Lasorsa F, di Meo NA, Rutigliano M, Milella M, Ferro M, Pandolfo SD, Crocetto F, Tataru OS, Autorino R, Battaglia M, Ditonno P, and Lucarelli G

Abstract

Renal cell carcinoma (RCC) is the seventh most common cancer in men and the ninth most common cancer in women worldwide. There is plenty of evidence about the role of the immune system in surveillance against tumors. Thanks to a better understanding of immunosurveillance mechanisms, immunotherapy has been introduced as a promising cancer treatment in recent years. Renal cell carcinoma (RCC) has long been thought chemoresistant but highly immunogenic. Considering that up to 30% of the patients present metastatic disease at diagnosis, and around 20-30% of patients undergoing surgery will suffer recurrence, we need to identify novel therapeutic targets. The introduction of immune checkpoint inhibitors (ICIs) in the clinical management of RCC has revolutionized the therapeutic approach against this tumor. Several clinical trials have shown that therapy with ICIs in combination or ICIs and the tyrosine kinase inhibitor has a very good response rate. In this review article we summarize the mechanisms of immunity modulation and immune checkpoints in RCC and discuss the potential therapeutic strategies in renal cancer treatment.

Published
2023
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