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14 results on '"Nonaka, Miki"'

1. Discovery of 7-Azanorbornane-Based Dual Agonists for the Delta and Kappa Opioid Receptors through an In Situ Screening Protocol

Author

Karaki, Fumika, primary, Takamori, Taro, additional, Kawakami, Koumei, additional, Sakurai, Sae, additional, Hidaka, Kyoko, additional, Ishii, Kei, additional, Oki, Tomoya, additional, Sato, Noriko, additional, Atsumi, Nao, additional, Ashizawa, Karin, additional, Taguchi, Ai, additional, Ura, Asuka, additional, Naruse, Toko, additional, Hirayama, Shigeto, additional, Nonaka, Miki, additional, Miyano, Kanako, additional, Uezono, Yasuhito, additional, and Fujii, Hideaki, additional

Published
2023
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2. Distinct Profiles of Desensitization of µ-Opioid Receptors Caused by Remifentanil or Fentanyl: In Vitro Assay with Cells and Three-Dimensional Structural Analyses

Author

Uezono, Eiko, primary, Mizobuchi, Yusuke, additional, Miyano, Kanako, additional, Ohbuchi, Katsuya, additional, Murata, Hiroaki, additional, Komatsu, Akane, additional, Manabe, Sei, additional, Nonaka, Miki, additional, Hirokawa, Takatsugu, additional, Yamaguchi, Keisuke, additional, Iseki, Masako, additional, Uezono, Yasuhito, additional, Hayashida, Masakazu, additional, and Kawagoe, Izumi, additional

Published
2023
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3. Evaluation of the Intracellular Signaling Activities of κ-Opioid Receptor Agonists, Nalfurafine Analogs; Focusing on the Selectivity of G-Protein- and β-Arrestin-Mediated Pathways

Author

Yamaguchi, Masahiro, primary, Miyano, Kanako, additional, Hirayama, Shigeto, additional, Karasawa, Yusuke, additional, Ohshima, Kaori, additional, Uezono, Eiko, additional, Komatsu, Akane, additional, Nonaka, Miki, additional, Fujii, Hideaki, additional, Yamaguchi, Keisuke, additional, Iseki, Masako, additional, Hayashida, Masakazu, additional, and Uezono, Yasuhito, additional

Published
2022
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5. The Steroidal Alkaloid Tomatidine and Tomatidine-Rich Tomato Leaf Extract Suppress the Human Gastric Cancer-Derived 85As2 Cells In Vitro and In Vivo via Modulation of Interferon-Stimulated Genes

Author

Fujimaki, Junya, primary, Sayama, Neo, additional, Shiotani, Shigenobu, additional, Suzuki, Takanori, additional, Nonaka, Miki, additional, Uezono, Yasuhito, additional, Oyabu, Mamoru, additional, Kamei, Yasutomi, additional, Nukaya, Haruo, additional, Wakabayashi, Keiji, additional, Morita, Akihito, additional, Sato, Tomoki, additional, and Miura, Shinji, additional

Published
2022
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6. In Vitro Analyses of Spinach-Derived Opioid Peptides, Rubiscolins: Receptor Selectivity and Intracellular Activities through G Protein- and β-Arrestin-Mediated Pathways

Author

Karasawa, Yusuke, primary, Miyano, Kanako, additional, Fujii, Hideaki, additional, Mizuguchi, Takaaki, additional, Kuroda, Yui, additional, Nonaka, Miki, additional, Komatsu, Akane, additional, Ohshima, Kaori, additional, Yamaguchi, Masahiro, additional, Yamaguchi, Keisuke, additional, Iseki, Masako, additional, Uezono, Yasuhito, additional, and Hayashida, Masakazu, additional

Published
2021
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7. Oxytocin Is a Positive Allosteric Modulator of κ-Opioid Receptors but Not δ-Opioid Receptors in the G Protein Signaling Pathway

Author

Miyano, Kanako, primary, Yoshida, Yuki, additional, Hirayama, Shigeto, additional, Takahashi, Hideki, additional, Ono, Haruka, additional, Meguro, Yoshiyuki, additional, Manabe, Sei, additional, Komatsu, Akane, additional, Nonaka, Miki, additional, Mizuguchi, Takaaki, additional, Fujii, Hideaki, additional, Higami, Yoshikazu, additional, Narita, Minoru, additional, and Uezono, Yasuhito, additional

Published
2021
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8. Intake of Radionuclides in the Trees of Fukushima Forests 4. Binding of Radioiodine to Xyloglucan

Author

Nonaka, Miki, Yasukawa, Chisato, Aoki, Shoko, Itakura, Masateru, Willför, Stefan, Capek, Peter, Shoseyov, Oded, Tsubokura, Masaharu, Baba, Kei’ichi, Kaida, Rumi, Taji, Teruaki, Sakata, Yoichi, Hayashi, Takahisa, Nonaka, Miki, Yasukawa, Chisato, Aoki, Shoko, Itakura, Masateru, Willför, Stefan, Capek, Peter, Shoseyov, Oded, Tsubokura, Masaharu, Baba, Kei’ichi, Kaida, Rumi, Taji, Teruaki, Sakata, Yoichi, and Hayashi, Takahisa

Abstract

The 1, 4-linked glucans such as xyloglucan and amylose are known to form a complex with iodine/iodide ions and to also be precipitated with CaCl2 in the presence of iodine. Here, we show that iodine gas could be specifically incorporated into xyloglucan. Furthermore, we show that [125I]I2 gas is, over time, incorporated at high levels into the entire outer surface of poplar seedlings but that spraying seedlings with abscisic acid to close stomata decreases the incorporation of the gas. There was less incorporation of the gas in a transgenic poplar overexpressing xyloglucanase at the early stages when compared with a wild type. This shows that xyloglucan serves as a key absorber of iodine gas into a plant body. After individual leaves of cultured seedlings were exposed to the gas for 30 min, no radioiodine was emitted from those leaves over the following two weeks, indicating that no turnover occurs in radioiodine once it is bound to the polysaccharides in plant tissues. We conclude that forest trees could serve as one of the largest enormous capture systems for the radioiodine fallout following the nuclear power plant accident in Fukushima.

Published
2020

9. Intake of Radionuclides in the Trees of Fukushima Forests 4. Binding of Radioiodine to Xyloglucan

Author

Nonaka, Miki, primary, Yasukawa, Chisato, additional, Aoki, Shoko, additional, Itakura, Masateru, additional, Willför, Stefan, additional, Capek, Peter, additional, Shoseyov, Oded, additional, Tsubokura, Masaharu, additional, Baba, Kei’ichi, additional, Kaida, Rumi, additional, Taji, Teruaki, additional, Sakata, Yoichi, additional, and Hayashi, Takahisa, additional

Published
2020
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10. Intake of Radionuclides in the tree of Fukushima Forests 2. Study of radiocesium flow to poplar seedlings as a model tree

Author

Aoki, Shoko, Nonaka, Miki, Yasukawa, Chisato, Itakura, Masateru, Tsubokura, Masaharu, Baba, Kei’ichi, Ohbayashi, Hiroya, Seyama, Tomoko, Uehara, Iwao, Kaida, Rumi, Taji, Teruaki, Sakata, Yoichi, Hayashi, Takahisa, Aoki, Shoko, Nonaka, Miki, Yasukawa, Chisato, Itakura, Masateru, Tsubokura, Masaharu, Baba, Kei’ichi, Ohbayashi, Hiroya, Seyama, Tomoko, Uehara, Iwao, Kaida, Rumi, Taji, Teruaki, Sakata, Yoichi, and Hayashi, Takahisa

Abstract

After the nuclear power plant accident in Fukushima, radionuclides were deposited over a large area of local forest. However, almost nothing is known about radionuclide infiltration into trees. Here, we used poplar seedlings as a model to show that radiocesium can enter directly into leaves and bark, moving via ray cells through the symplastic pathways to the xylem and concentrating around the meristems, cork, and vascular cambium. During induced potassium incorporation and reduced seasonal growth, the radiocesium in the meristems of stems mainly passes into abscission tissues such as leaves and heartwood. There is no turnover of radiocesium after it enters the heartwood.

Published
2019

11. Intake of Radionuclides in the Trees of Fukushima Forests 1. Field Study

Author

Yasukawa, Chisato, Aoki, Shoko, Nonaka, Miki, Itakura, Masateru, Tsubokura, Masaharu, Baba, Kei’ichi, Ohbayashi, Hiroya, Sugawara, Izumi, Seyama, Tomoko, Uehara, Iwao, Kaida, Rumi, Taji, Teruaki, Sakata, Yoichi, Hayashi, Takahisa, Yasukawa, Chisato, Aoki, Shoko, Nonaka, Miki, Itakura, Masateru, Tsubokura, Masaharu, Baba, Kei’ichi, Ohbayashi, Hiroya, Sugawara, Izumi, Seyama, Tomoko, Uehara, Iwao, Kaida, Rumi, Taji, Teruaki, Sakata, Yoichi, and Hayashi, Takahisa

Abstract

The earthquake and tsunami on 11 March 2011 led to a meltdown followed by a hydrogen explosion at the Fukushima–Daiichi nuclear power plant in Japan, causing the dispersal of abundant radionuclides into the atmosphere and ocean. The radionuclides were deposited onto trees and local residences in aerosol or gaseous forms that were partly absorbed by rain or melting snow. Here, we show that the radionuclides attached to the surfaces of trees, in which some radiocesium was incorporated into the xylem through ray cells and through symplastic pathways. The level of incorporated radiocesium varied based on tree species and age because of the ability of radiocesium to attach to the surface of the outer bark. After four years, the radiocesium level in the forest has been decreasing as it is washed out with rainwater into the sea and as it decays over time due to its half-life, but it can also be continuously recycled through leaf tissue, litter, mulch, and soil. As a result, the level of radiocesium was relatively increased in the heartwood and roots of trees at four years after the event. In private forest fields, most trees were left as afforested trees without being used for timber, although some trees were cut down. We discuss an interdisciplinary field study on the immediate effects of high radiation levels upon afforested trees in private forest fields.

Published
2019

12. Intake of Radionuclides in the Trees of Fukushima Forests 2. Study of Radiocesium Flow to Poplar Seedlings as a Model Tree

Author

Aoki, Shoko, primary, Nonaka, Miki, additional, Yasukawa, Chisato, additional, Itakura, Masateru, additional, Tsubokura, Masaharu, additional, Baba, Kei’ichi, additional, Ohbayashi, Hiroya, additional, Seyama, Tomoko, additional, Uehara, Iwao, additional, Kaida, Rumi, additional, Taji, Teruaki, additional, Sakata, Yoichi, additional, and Hayashi, Takahisa, additional

Published
2019
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13. Intake of Radionuclides in the Trees of Fukushima Forests 1. Field Study

Author

Yasukawa, Chisato, primary, Aoki, Shoko, additional, Nonaka, Miki, additional, Itakura, Masateru, additional, Tsubokura, Masaharu, additional, Baba, Kei’ichi, additional, Ohbayashi, Hiroya, additional, Sugawara, Izumi, additional, Seyama, Tomoko, additional, Uehara, Iwao, additional, Kaida, Rumi, additional, Taji, Teruaki, additional, Sakata, Yoichi, additional, and Hayashi, Takahisa, additional

Published
2019
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14. Carboplatin Enhances the Activity of Human Transient Receptor Potential Ankyrin 1 through the Cyclic AMP-Protein Kinase A-A-Kinase Anchoring Protein (AKAP) Pathways

Author

Miyano, Kanako, primary, Shiraishi, Seiji, additional, Minami, Koichiro, additional, Sudo, Yuka, additional, Suzuki, Masami, additional, Yokoyama, Toru, additional, Terawaki, Kiyoshi, additional, Nonaka, Miki, additional, Murata, Hiroaki, additional, Higami, Yoshikazu, additional, and Uezono, Yasuhito, additional

Published
2019
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