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Your search keyword '"Niels G A Willemen"' showing total 2 results
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2 results on '"Niels G A Willemen"'

1. Immune Organs and Immune Cells on a Chip: An Overview of Biomedical Applications

Author

Margaretha A. J. Morsink, Niels G. A. Willemen, Jeroen Leijten, Ruchi Bansal, and Su Ryon Shin

Subjects
immune system, microfluidics, immune cells, organ-on-a-chip, 3D in vitro model, immune system-on-a-chip, Mechanical engineering and machinery, TJ1-1570
Abstract

Understanding the immune system is of great importance for the development of drugs and the design of medical implants. Traditionally, two-dimensional static cultures have been used to investigate the immune system in vitro, while animal models have been used to study the immune system’s function and behavior in vivo. However, these conventional models do not fully emulate the complexity of the human immune system or the human in vivo microenvironment. Consequently, many promising preclinical findings have not been reproduced in human clinical trials. Organ-on-a-chip platforms can provide a solution to bridge this gap by offering human micro-(patho)physiological systems in which the immune system can be studied. This review provides an overview of the existing immune-organs-on-a-chip platforms, with a special emphasis on interorgan communication. In addition, future challenges to develop a comprehensive immune system-on-chip model are discussed.

Published
2020
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2. Immune Organs and Immune Cells on a Chip: An Overview of Biomedical Applications

Author

Niels G A Willemen, Su Ryon Shin, Margaretha Morsink, Jeroen Leijten, and Ruchi Bansal

Subjects
TheoryofComputation_MISCELLANEOUS, Computer science, animal diseases, lcsh:Mechanical engineering and machinery, microfluidics, chemical and pharmacologic phenomena, 02 engineering and technology, Review, Organ-on-a-chip, 03 medical and health sciences, Immune system, immune cells, lcsh:TJ1-1570, Electrical and Electronic Engineering, 030304 developmental biology, 0303 health sciences, organ-on-a-chip, Mechanical Engineering, immune system-on-a-chip, biochemical phenomena, metabolism, and nutrition, 021001 nanoscience & nanotechnology, immune system, 3D in vitro model, Control and Systems Engineering, bacteria, 0210 nano-technology, Neuroscience
Abstract

Understanding the immune system is of great importance for the development of drugs and the design of medical implants. Traditionally, two-dimensional static cultures have been used to investigate the immune system in vitro, while animal models have been used to study the immune system’s function and behavior in vivo. However, these conventional models do not fully emulate the complexity of the human immune system or the human in vivo microenvironment. Consequently, many promising preclinical findings have not been reproduced in human clinical trials. Organ-on-a-chip platforms can provide a solution to bridge this gap by offering human micro-(patho)physiological systems in which the immune system can be studied. This review provides an overview of the existing immune-organs-on-a-chip platforms, with a special emphasis on interorgan communication. In addition, future challenges to develop a comprehensive immune system-on-chip model are discussed.

Published
2020

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