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2 results on '"N-AHL"'

1. Classifying the Topology of AHL-Driven Quorum Sensing Circuits in Proteobacterial Genomes

Author

Sándor Pongor, Vittorio Venturi, Borisz Galbáts, Zsolt Gelencsér, Kumari Sonal Choudhary, Bruna Goncalves Coutinho, and Sanjarbek Hudaiberdiev

Subjects
quorum sensing, N-AHL, topology, proteobacteria, bacteria, Chemical technology, TP1-1185
Abstract

Virulence and adaptability of many Gram-negative bacterial species are associated with an N-acylhomoserine lactone (AHL) gene regulation mechanism called quorum sensing (QS). The arrangement of quorum sensing genes is variable throughout bacterial genomes, although there are unifying themes that are common among the various topological arrangements. A bioinformatics survey of 1,403 complete bacterial genomes revealed characteristic gene topologies in 152 genomes that could be classified into 16 topological groups. We developed a concise notation for the patterns and show that the sequences of LuxR regulators and LuxI autoinducer synthase proteins cluster according to the topological patterns. The annotated topologies are deposited online with links to sequences and genome annotations at http://bacteria.itk.ppke.hu/QStopologies/.

Published
2012
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2. The Organization of the Quorum Sensing luxI/R Family Genes in Burkholderia

Author

Zsolt Gelencser, Sanjarbek Hudaiberdiev, Kumari Sonal Choudhary, Vittorio Venturi, Bruna G. Coutinho, and Sándor Pongor

Subjects
Burkholderia, Niche, Homoserine, Article, Catalysis, Microbiology, Inorganic Chemistry, lcsh:Chemistry, chemistry.chemical_compound, Bacterial Proteins, N-AHL, Animals, Humans, chromosomal arrangements, Physical and Theoretical Chemistry, Clade, Molecular Biology, Gene, lcsh:QH301-705.5, Spectroscopy, Genetics, Rhizosphere, biology, Organic Chemistry, food and beverages, quorum sensing, General Medicine, biology.organism_classification, Computer Science Applications, Repressor Proteins, Quorum sensing, chemistry, local topologies, lcsh:Biology (General), lcsh:QD1-999, Genes, Bacterial, Trans-Activators, bacteria, Proteobacteria, Transcription Factors
Abstract

Members of the Burkholderia genus of Proteobacteria are capable of living freely in the environment and can also colonize human, animal and plant hosts. Certain members are considered to be clinically important from both medical and veterinary perspectives and furthermore may be important modulators of the rhizosphere. Quorum sensing via N-acyl homoserine lactone signals (AHL QS) is present in almost all Burkholderia species and is thought to play important roles in lifestyle changes such as colonization and niche invasion. Here we present a census of AHL QS genes retrieved from public databases and indicate that the local arrangement (topology) of QS genes, their location within chromosomes and their gene neighborhoods show characteristic patterns that differ between the known Burkholderia clades. In sequence phylogenies, AHL QS genes seem to cluster according to the local gene topology rather than according to the species, which suggests that the basic topology types were present prior to the appearance of current Burkholderia species. The data are available at http://net.icgeb.org/burkholderia/.

Published
2013

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