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3 results on '"Moreno S Rodrigues"'

1. New Insights on the Zika Virus Arrival in the Americas and Spatiotemporal Reconstruction of the Epidemic Dynamics in Brazil

Author

Qeren Hapuk Rodrigues Ferreira Fernandes, Larissa C. Costa, Artur T. L. Queiroz, Enny S. Paixão, Tiago Gräf, Maria Glória Teixeira, José Í K Gonçalves, Luciana L. Cardim, Rafael V. Veiga, Wanderson K Oliveira, Maria da Conceição Nascimento Costa, Eduardo Hage Carmo, Moreno S. Rodrigues, Mauricio Lima Barreto, Juliane F. Oliveira, and Roberto F. S. Andrade

Subjects
0301 basic medicine, 030106 microbiology, lcsh:QR1-502, Epidemic dynamics, Genome, Viral, phylogeography, Article, lcsh:Microbiology, Disease Outbreaks, Zika virus, 03 medical and health sciences, Spatio-Temporal Analysis, Virology, Humans, Public Health Surveillance, Clade, Phylogeny, ZIKV, biology, Zika Virus Infection, molecular clock, Zika Virus, biology.organism_classification, 030104 developmental biology, Infectious Diseases, Geography, Americas, Cartography, Brazil
Abstract

Zika virus (ZIKV) became a worldwide public health emergency after its introduction in the Americas. Brazil was implicated as central in the ZIKV dispersion, however, a better understanding of the pathways the virus took to arrive in Brazil and the dispersion within the country is needed. An updated genome dataset was assembled with publicly available data. Bayesian phylogeography methods were applied to reconstruct the spatiotemporal history of ZIKV in the Americas and with more detail inside Brazil. Our analyses reconstructed the Brazilian state of Pernambuco as the likely point of introduction of ZIKV in Brazil, possibly during the 2013 Confederations Cup. Pernambuco played an important role in spreading the virus to other Brazilian states. Our results also underscore the long cryptic circulation of ZIKV in all analyzed locations in Brazil. Conclusions: This study brings new insights about the early moments of ZIKV in the Americas, especially regarding the Brazil-Haiti cluster at the base of the American clade and describing for the first time migration patterns within Brazil.

Published
2020

2. New Insights on the Zika Virus Arrival in the Americas and Spatiotemporal Reconstruction of the Epidemic Dynamics in Brazil

Author

Larissa Catharina Costa, Rafael Valente Veiga, Juliane Fonseca Oliveira, Moreno S. Rodrigues, Roberto F. S. Andrade, Enny S. Paixão, Maria Glória Teixeira, Maria da Conceição N. Costa, Luciana L. Cardim, Eduardo H. Carmo, Wanderson K. Oliveira, José Í. K. Gonçalves, Qeren H. R. F. Fernandes, Maurício L. Barreto, Artur T. L. Queiroz, and Tiago Gräf

Subjects
ZIKV, Brazil, phylogeography, molecular clock, Microbiology, QR1-502
Abstract

Zika virus (ZIKV) became a worldwide public health emergency after its introduction in the Americas. Brazil was implicated as central in the ZIKV dispersion, however, a better understanding of the pathways the virus took to arrive in Brazil and the dispersion within the country is needed. An updated genome dataset was assembled with publicly available data. Bayesian phylogeography methods were applied to reconstruct the spatiotemporal history of ZIKV in the Americas and with more detail inside Brazil. Our analyses reconstructed the Brazilian state of Pernambuco as the likely point of introduction of ZIKV in Brazil, possibly during the 2013 Confederations Cup. Pernambuco played an important role in spreading the virus to other Brazilian states. Our results also underscore the long cryptic circulation of ZIKV in all analyzed locations in Brazil. Conclusions: This study brings new insights about the early moments of ZIKV in the Americas, especially regarding the Brazil-Haiti cluster at the base of the American clade and describing for the first time migration patterns within Brazil.

Published
2020
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3. Case Fatality Rate Related to Microcephaly Congenital Zika Syndrome and Associated Factors: A Nationwide Retrospective Study in Brazil †

Author

Maria Conceição N. Costa, Luciana Lobato Cardim, Maria Gloria Teixeira, Mauricio L. Barreto, Rita de Cassia Oliveira de Carvalho-Sauer, Florisneide R. Barreto, Martha Suely Itaparica Carvalho, Wanderson K. Oliveira, Giovanny V. A. França, Eduardo Hage Carmo, Roberto F. S Andrade, Moreno S. Rodrigues, Rafael V. Veiga, Juliane F. Oliveira, Qeren H. R. F. Fernandes, Larissa C. Costa, Giovanini E. Coelho, and Enny S. Paixao

Subjects
congenital Zika syndrome, microcephaly, case fatality rate, risks factors, Microbiology, QR1-502
Abstract

Background: The clinical manifestations of microcephaly/congenital Zika syndrome (microcephaly/CZS) have harmful consequences on the child’s health, increasing vulnerability to childhood morbidity and mortality. This study analyzes the case fatality rate and child–maternal characteristics of cases and deaths related to microcephaly/CZS in Brazil, 2015–2017. Methods: Population-based study developed by linkage of three information systems. We estimate frequencies of cases, deaths, case fatality rate related to microcephaly/CZS according to child and maternal characteristics and causes of death. Multivariate logistic regression models were applied. Results: The microcephaly/CZS case fatality rate was 10% (95% CI 9.2–10.7). Death related to microcephaly/CZS was associated to moderate (OR = 2.15; 95% CI 1.63–2.83), and very low birth weight (OR = 3.77; 95% CI 2.20–6.46); late preterm births (OR = 1.65; 95% CI 1.21–2.23), Apgar < 7 at 1st (OR = 5.98; 95% CI 4.46–8.02) and 5th minutes (OR = 4.13; 95% CI 2.78–6.13), among others. Conclusions: A high microcephaly/CZS case fatality rate and important factors associated with deaths related to this syndrome were observed. These results can alert health teams to these problems and increase awareness about the factors that may be associated with worse outcomes.

Published
2020
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