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Vacant land in residual urban areas is a crucial resource to tackle the current climate and housing crises. In this study, we present the development of a geodatabase to determine the occurrence of vacant land in the urban core of Oklahoma City, USA (OKC), and assess its potential for infill housing. As a starting point, we define urban vacant land through a literature review. We present a description of the case study’s social and urbanistic context by highlighting its relevance to this study. We explain the methodology for the development of the geodatabase to quantify residual urban land in OKC’s urban core. We examine the spatial distribution and recurring characteristics of vacant parcels using QGIS, Python scripting for Rhinoceros 3D, and aerial imagery. We find that small parcels have higher vacancy rates than average-sized parcels and there is a correlation between higher vacancy rates and proximity to downtown and brownfields. Finally, we discuss the implications of the findings by assessing the urban vacant land potential for residential development and its contribution to OKC’s housing provision. Under all the proposed scenarios, the considered developable vacant land in the urban core could entirely fulfill the need for new housing units for the entire city.

Venoms are a rich source of bioactive compounds, and among them is leberagin-C (Leb-C), a disintegrin-like protein derived from the venom of Macrovipera lebetina transmediterrannea snakes. Leb-C has shown promising inhibitory effects on platelet aggregation. Previous studies have demonstrated that this SECD protein specifically targets α5β1, αvβ3, and αvβ6 integrins through a mimic mechanism of RGD disintegrins. In our current study, we focused on exploring the potential effects of Leb-C on metastatic breast cancer. Our findings revealed that Leb-C disrupted the adhesion, migration, and invasion capabilities of MDA-MB-231 breast cancer cells and its highly metastatic D3H2LN sub-population. Additionally, we observed significant suppression of adhesion, migration, and invasion of human umbilical vein endothelial cells (HUVECs). Furthermore, Leb-C demonstrated a strong inhibitory effect on fibroblast-growth-factor-2-induced proliferation of HUVEC. We conducted in vivo experiments using nude mice and found that treatment with 2 µM of Leb-C resulted in a remarkable 73% reduction in D3H2LN xenograft tumor size. Additionally, quantification of intratumor microvessels revealed a 50% reduction in tumor angiogenesis in xenograft after 21 days of twice-weekly treatment with 2 µM of Leb-C. Collectively, these findings suggest the potential utility of this disintegrin-like protein for inhibiting aggressive and resistant metastatic breast cancer.

Candida and dermatophyte infections are difficult to treat due to increasing antifungal drugs resistance such as fluconazole, as well as the emergence of multi-resistance in clinical bacteria. Here, we first synthesized silver nanoparticles using aqueous fruit extracts from Scabiosa atropurpurea subsp. maritima (L.). The characterization of the AgNPs by means of UV, XRD, FTIR, and TEM showed that the AgNPs had a uniform spherical shape with average sizes of 40–50 nm. The biosynthesized AgNPs showed high antioxidant activity when investigated using 1,1-diphenyl-2-picryl-hydrazyl (DPPH) and ferric reducing antioxidant power (FRAP) assays. The AgNPs displayed strong antibacterial potential expressed by the maximum zone inhibition and the lowest MIC and MBC values. The AgNPs revealed a significant antifungal effect against the growth and biofilm of Candida species. In fact, the AgNPs were efficient against Trichophyton rubrum, Trichophyton interdigitale, and Microsporum canis. The antifungal mechanisms of action of the AgNPs seem to be due to the disruption of membrane integrity and a reduction in virulence factors (biofilm and hyphae formation and a reduction in germination). Finally, the silver nanoparticles also showed important cytotoxic activity against the human multiple myeloma U266 cell line and the human breast cancer cell line MDA-MB-231. Therefore, we describe new silver nanoparticles with promising biomedical application in the development of novel antimicrobial and anticancer agents.

The advent of renewable energy resources and distributed energy systems herald a new set of challenges of power quality, efficient distribution, and stability in the power system. Furthermore, the power electronic converters integration has been increased in interfacing alternate energy systems and industries with the transmission and distribution grids. Owing to the intermittency of renewable energy resources and the application of power electronic converters the power distribution faces peculiar challenges. The dead-time effects are among the main challenges, which leads to the distortion of third harmonics, phase angle, torque pulsation, and induction motor current, causing severe quality problems for power delivery. To tackle these problems, this paper proposes a novel dead time compensation technique for improving the power quality parameters and improving the efficiency of power converters. The proposed model is simulated in MATLAB and the parametric equations are plotted against the corresponding parametric values. Furthermore, by implementing the proposed strategy, significant improvements are attained in the torque pulsation, speed, and total harmonic distortion of the induction motor. The comparisons are drawn between with and without dead time compensation technique, the former shows significant improvements in all aspects of the power quality parameters and power converters efficiency.

With the gradual increase in the installed capacity of wind turbines, more and more attention has been paid to the economy of wind power. Economic model-predictive control (EMPC) has been developed as an effective advanced control strategy, which can improve the dynamic economy performance of the system. However, the variable-speed wind turbine (VSWT) system widely used is generally nonlinear and highly coupled nonaffine systems, containing multiple economic terms. Therefore, a nonlinear EMPC strategy considering power maximization and mechanical load minimization is proposed based on the comprehensive VSWT model, including the dynamics of the tower and the gearbox in this paper. Three groups of simulations verify the effectiveness and reliability/practicability of the proposed nonlinear EMPC strategy.