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1. In Vivo Assessment of Healing Potential of Ointments Containing Bee Products, Vegetal Extracts, and Polymers on Skin Lesions

Author

Calin Vasile Andritoiu, Cristina Lungu, Camelia Elena Iurciuc (Tincu), Corina Elena Andriescu, Corneliu Havarneanu, Marcel Popa, Magdalena Cuciureanu, Liliana Mititelu Tarţău, and Bianca Ivanescu

Subjects
wound healing, apitherapy products, natural polymers, vegetal extracts, Medicine, Pharmacy and materia medica, RS1-441
Abstract

Background/Objectives: The present experiment aimed to formulate four ointments that included mixtures of plant extracts (Hippophae rhamnoides, Calendula officinalis, Arctium lappa, and Achillea millefolium), apitherapy products (honey, propolis, and apilarnil) and natural polymers (collagen, chitosan, and the lyophilisate of egg white) in an ointment base. Methods: In order to investigate the therapeutic properties of the ointments, experimental in vivo injury models (linear incision, circular excision, and thermal burns) were performed on laboratory animals, namely Wistar rats. The treatment was applied topically, once a day, for 21 days. Clinical and macroscopic evaluation, determination of lesion shrinkage rate, re-epithelialization period, and histopathological examination were performed. Results: The results demonstrate that the tested ointments have a significant effect in healing skin lesions. On the ninth day of treatment, the wound contraction rate was 98.17 ± 0.15% for the mixed ointment group, compared to the negative control group’s rate of 14.85 ± 2.95%. At day 21, dermal collagenization and restoration of histological structure occurred for all treated groups. Conclusions: The tested ointments exerted in vivo wound healing and re-epithelialization effects on incision, excision, and thermal burn injuries.

Published
2025
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2. Advanced Amperometric Microsensors for the Electrochemical Quantification of Quercetin in Ginkgo biloba Essential Oil from Regenerative Farming Practices

Author

Elena Oancea, Ioana Adina Tula, Gabriela Stanciu, Raluca-Ioana Ștefan-van Staden, Jacobus (Koos) Frederick van Staden, and Magdalena Mititelu

Subjects
carbon nanopowder, chitosan, differential pulse voltammetry, essential oils, graphite, tetraphenyl-porphine cobalt (II), Microbiology, QR1-502
Abstract

In this study, we present a novel approach using amperometric microsensors to detect quercetin in cosmetic formulations and track its metabolic behavior after topical application. This method offers a sensitive, real-time alternative to conventional techniques, enabling the detection of quercetin’s bioavailability, its transformation into active metabolites, and its potential therapeutic effects when applied to the skin. Quercetin (Q) is a bioactive flavonoid known for its potent antioxidant properties, naturally present in numerous plants, particularly those with applications in cosmetic formulations. In response to the growing interest in developing novel plant-based dermo-cosmetic solutions, this study investigates the electrochemical detection of quercetin, a ketone-type flavonoid, extracted from Gingko biloba essential oil. Three newly designed amperometric microsensors were developed to assess their efficacy in detecting quercetin in botanical samples. The sensor configurations utilized two forms of carbon material as a foundation: graphite (G) and carbon nanoparticles (CNs). These base materials were modified with paraffin oil, chitosan (CHIT), and cobalt(II) tetraphenylporphyrin (Co(II)TPP) to enhance sensitivity. Differential pulse voltammetry (DPV) served as the analytical method for this investigation. Among the sensors, the CHIT/G–CN microsensor exhibited the highest sensitivity, with a detection limit of 1.22 × 10−7 mol L−1, followed by the G–CN (5.64 × 10−8 mol L−1) and Co(II)TPP/G–CN (9.80 × 10−8 mol L−1) microsensors. The minimum detectable concentration was observed with the G–CN and CoP/G–CN microsensors, achieving a threshold as low as 0.0001 μmol L−1. Recovery rates and relative standard deviation (RSD) values averaged 97.4% ± 0.43, underscoring the sensors’ reliability for quercetin detection in botanical matrices.

Published
2024
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3. Enhanced Stability and In Vitro Biocompatibility of Chitosan-Coated Lipid Vesicles for Indomethacin Delivery

Author

Angy Abu Koush, Eliza Gratiela Popa, Daniela Angelica Pricop, Loredana Nita, Cezar-Ilie Foia, Ana-Maria Raluca Pauna, Beatrice Rozalina Buca, Liliana Lacramioara Pavel, and Liliana Mititelu-Tartau

Subjects
indomethacin, chitosan, lipid vesicles, biocompatibility, mice, Pharmacy and materia medica, RS1-441
Abstract

Background: Lipid vesicles, especially those utilizing biocompatible materials like chitosan (CHIT), hold significant promise for enhancing the stability and release characteristics of drugs such as indomethacin (IND), effectively overcoming the drawbacks associated with conventional drug formulations. Objectives: This study seeks to develop and characterize novel lipid vesicles composed of phosphatidylcholine and CHIT that encapsulate indomethacin (IND-ves), as well as to evaluate their in vitro hemocompatibility. Methods: The systems encapsulating IND were prepared using a molecular droplet self-assembly technique, involving the dissolution of lipids, cholesterol, and indomethacin in ethanol, followed by sonication and the gradual incorporation of a CHIT solution to form stable vesicular structures. The vesicles were characterized in terms of size, morphology, Zeta potential, and encapsulation efficiency and the profile release of drug was assessd. In vitro hemocompatibility was evaluated by measuring erythrocyte lysis and quantifying hemolysis rates. Results: The IND-ves exhibited an entrapment efficiency of 85%, with vesicles averaging 317.6 nm in size, and a Zeta potential of 24 mV, indicating good stability in suspension. In vitro release kinetics demonstrated an extended release profile of IND from the vesicles over 8 h, contrasting with the immediate release observed from plain drug solutions. The hemocompatibility assessment revealed that IND-ves exhibited minimal hemolysis, comparable to control groups, indicating good compatibility with erythrocytes. Conclusions: IND-ves provide a promising approach for modified indomethacin delivery, enhancing stability and hemocompatibility. These findings suggest their potential for effective NSAID delivery, with further in vivo studies required to explore clinical applications.

Published
2024
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4. Polyunsaturated Fatty Acids and Human Health: A Key to Modern Nutritional Balance in Association with Polyphenolic Compounds from Food Sources

Author

Magdalena Mititelu, Dumitru Lupuliasa, Sorinel Marius Neacșu, Gabriel Olteanu, Ștefan Sebastian Busnatu, Andreea Mihai, Violeta Popovici, Nicoleta Măru, Steluța Constanța Boroghină, Sebastian Mihai, Corina-Bianca Ioniță-Mîndrican, and Alexandru Scafa-Udriște

Subjects
monounsaturated fatty acids, polyunsaturated fatty acids, saturated fats, metabolic syndrome, essential fatty acids, marine lipids, Chemical technology, TP1-1185
Abstract

Polyunsaturated fatty acids (PUFAs) are vital dietary elements that play a significant role in human nutrition. They are highly regarded for their positive contributions to overall health and well-being. Beyond the fact that they provide a substantial supply of energy to the body (a role that saturated fats can also perform), these unsaturated fatty acids and, especially, the essential ones are involved in cell membrane structure, blood pressure regulation, and coagulation; participate in the proper functioning of the immune system and assimilation of fat-soluble vitamins; influence the synthesis of pro- and anti-inflammatory substances; and protect the cardiovascular system. Modern diets like the Western diet and the American diet are rich in saturated fats found especially in fast food products, sweets, and processed foods, a fact that has led to an increase in the prevalence of metabolic diseases worldwide (obesity, type II diabetes, gout, cardiovascular disease). Nutritionists have drawn attention to the moderate consumption of saturated fats and the need to increase the intake of unsaturated fats to the detriment of saturated ones. This paper examines the biochemical roles of polyunsaturated fats, particularly essential fatty acids, and contrasts their benefits with the detrimental effects of saturated fat overconsumption. Furthermore, it highlights the necessity for dietary shifts towards increased PUFA intake to mitigate the global burden of diet-related health issues. The co-occurrence of PUFAs and polyphenols in plant-based foods highlights the sophistication of nature’s design. These bioactive compounds are not randomly distributed but are present in foods humans have consumed together historically. From traditional diets like the Mediterranean, which pairs olive oil (PUFAs and polyphenols) with vegetables and legumes, to Asian cuisines combining sesame seeds with turmeric, cultural practices have long harnessed this natural synergy.

Published
2024
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5. Exploring the Impact of Semaglutide on Cognitive Function and Anxiety-Related Behaviors in a Murine Model of Alzheimer’s Disease

Author

Ianis Kevyn Stefan Boboc, Petrica-Daniel Dumitrelea, Andreea Daniela Meca, Liliana Mititelu-Tartau, and Maria Bogdan

Subjects
semaglutide, Alzheimer’s disease, murine models, open field test, novel object recognition test, social chamber test, Biology (General), QH301-705.5
Abstract

Background: Alzheimer’s disease (AD), the most prevalent form of dementia, is characterized by progressive cognitive decline and behavioral disturbances, with an increasing incidence as the global population ages. This study investigates the effects of semaglutide (SEM), a glucagon-like peptide-1 analog, on cognitive function and anxiety-like behavior in a transgenic murine model of AD. Methods: 20 mice were randomly distributed into the following groups (n = 5): (WT + VEH) group: C57BL/6J + saline, (WT + SEM) group: C57BL/6J + semaglutide, (AD + VEH) group: AD + saline, (AD + SEM) group: AD + semaglutide. The animals underwent a four-week treatment, during which we monitored blood glucose levels, body weight, and responses in an open field test, novel object recognition test, social chamber test, and 0-maze test. Results: Post-treatment, SEM significantly reduced blood glucose levels in AD mice, aligning them with those of wild-type controls. Cognitive assessments indicated an improvement in the investigation index for SEM-treated mice compared to those receiving a vehicle, suggesting cognitive benefits. Although SEM did not significantly enhance motor and exploratory activities, it displayed a potential anxiolytic effect, particularly evident in the combined anxiety index, with notable differences observed before and after treatment in the AD group. Conclusions: The findings of this pilot study suggest that SEM may play a dual role in managing AD by improving glycemic control and potentially enhancing cognitive function. As the landscape of AD treatment evolves, the comprehensive approach of utilizing SEM could pave the way for innovative interventions targeting the complex interplay of metabolic and cognitive dysfunctions in this challenging neurodegenerative disorder.

Published
2024
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6. Digestive Amyloidosis Trends: Clinical, Pathological, and Imaging Characteristics

Author

Sandica Bucurica, Andreea-Simona Nancoff, Miruna Valeria Moraru, Ana Bucurica, Calin Socol, Daniel-Vasile Balaban, Mihaela Raluca Mititelu, Ionela Maniu, Florentina Ionita-Radu, and Mariana Jinga

Subjects
digestive amyloidosis, amyloid deposits, digestive motility, amyloid light chains, gastrointestinal amyloidosis, Biology (General), QH301-705.5
Abstract

Amyloidosis is a group of diseases characterized by the extracellular deposition of abnormally folded, insoluble proteins that lead to organ dysfunction. While it commonly affects the cardiovascular system, gastrointestinal (GI) tract involvement is undetermined. Recent research has focused on understanding the pathophysiology, diagnostic challenges, and therapeutic approaches to GI amyloidosis, particularly in systemic amyloid light-chain (AL) and amyloid A (AA) forms. GI manifestations can include motility disorders, bleeding, and, in severe cases, bowel obstruction. This review highlights the importance of the early recognition of digestive symptoms and associated imagistic findings in GI amyloidosis by analyzing the research that included clinical, pathological, and endoscopic approaches to amyloidosis. A systematic search of the PubMed and Scopus databases identified 19 relevant studies. Our findings showed that amyloid deposits commonly affect the entire GI tract, with AL amyloidosis being the most predominant form. Endoscopic evaluations and biopsy remain key diagnostic tools, with Congo Red staining and mass spectrometry being used to confirm amyloid type. Although progress has been made in diagnosis, the absence of targeted therapies and the indistinct nature of GI symptoms continue to be challenging.

Published
2024
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7. Hydrogel for Sustained Delivery of Therapeutic Agents

Author

Adina Magdalena Musuc, Magdalena Mititelu, and Mariana Chelu

Subjects
n/a, Science, Chemistry, QD1-999, Inorganic chemistry, QD146-197, General. Including alchemy, QD1-65
Abstract

In recent years, hydrogels have emerged as a highly promising platform for the sustained delivery of therapeutic agents, addressing critical challenges in drug delivery systems, from controlled release to biocompatibility [...]

Published
2024
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8. Evaluation of the Consumption of Junk Food Products and Lifestyle among Teenagers and Young Population from Romania

Author

Mititelu, Magdalena, primary, Stanciu, Gabriela, additional, Licu, Monica, additional, Neacșu, Sorinel Marius, additional, Călin, Mariana Floricica, additional, Roșca, Adrian Cosmin, additional, Stanciu, Tiberius Iustinian, additional, Busnatu, Ștefan Sebastian, additional, Olteanu, Gabriel, additional, Boroghină, Steluța Constanța, additional, Nicolescu, Teodor Octavian, additional, Suciu, Felicia, additional, and Lupu, Carmen Elena, additional

Published
2024
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9. Comprehensive Analysis of Novel Synergistic Antioxidant Formulations: Insights into Pharmacotechnical, Physical, Chemical, and Antioxidant Properties

Author

Neacșu, Sorinel Marius, primary, Mititelu, Magdalena, additional, Ozon, Emma Adriana, additional, Musuc, Adina Magdalena, additional, Iuga, Izabela Dana Maria, additional, Manolescu, Bogdan Nicolae, additional, Petrescu, Simona, additional, Pandele Cusu, Jeanina, additional, Rusu, Adriana, additional, Surdu, Vasile-Adrian, additional, Oprea, Eliza, additional, Lupuliasa, Dumitru, additional, and Popescu, Ioana Andreea, additional

Published
2024
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10. Assessment of Dietary and Lifestyle Quality among the Romanian Population in the Post-Pandemic Period

Author

Mititelu, Magdalena, primary, Popovici, Violeta, additional, Neacșu, Sorinel Marius, additional, Musuc, Adina Magdalena, additional, Busnatu, Ștefan Sebastian, additional, Oprea, Eliza, additional, Boroghină, Steluța Constanța, additional, Mihai, Andreea, additional, Streba, Costin Teodor, additional, Lupuliasa, Dumitru, additional, Gheorghe, Emma, additional, Kebbewar, Nadin, additional, and Lupu, Carmen Elena, additional

Published
2024
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14. Incidence of Urinary Infections and Behavioral Risk Factors

Author

Mititelu, Magdalena, primary, Olteanu, Gabriel, additional, Neacșu, Sorinel Marius, additional, Stoicescu, Iuliana, additional, Dumitrescu, Denisa-Elena, additional, Gheorghe, Emma, additional, Tarcea, Monica, additional, Busnatu, Ștefan Sebastian, additional, Ioniță-Mîndrican, Corina-Bianca, additional, Tafuni, Ovidiu, additional, Belu, Ionela, additional, Popescu, Antoanela, additional, Lupu, Sergiu, additional, and Lupu, Carmen Elena, additional

Published
2024
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18. Alginate-Based Hydrogels Enriched with Lavender Essential Oil: Evaluation of Physicochemical Properties, Antimicrobial Activity, and In Vivo Biocompatibility

Author

Rusu, Alina Gabriela, primary, Niță, Loredana Elena, additional, Roșca, Irina, additional, Croitoriu, Alexandra, additional, Ghilan, Alina, additional, Mititelu-Tarțău, Liliana, additional, Grigoraș, Aurica Valentin, additional, Crețu, Bianca-Elena-Beatrice, additional, and Chiriac, Aurica P., additional

Published
2023
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21. Evaluation of Non-Alcoholic Beverages and the Risk Related to Consumer Health among the Romanian Population

Author

Mititelu, Magdalena, primary, Oancea, Carmen-Nicoleta, additional, Neacșu, Sorinel Marius, additional, Olteanu, Gabriel, additional, Cîrțu, Alexandru-Tiberiu, additional, Hîncu, Lucian, additional, Gheonea, Theodora Claudia, additional, Stanciu, Tiberius Iustinian, additional, Rogoveanu, Ion, additional, Hashemi, Fallah, additional, Stanciu, Gabriela, additional, Ioniță-Mîndrican, Corina-Bianca, additional, Angelica, Caunii, additional, Măru, Nicoleta, additional, Lupu, Sergiu, additional, and Lupu, Carmen Elena, additional

Published
2023
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24. Evaluation of Junk Food Consumption and the Risk Related to Consumer Health among the Romanian Population

Author

Mititelu, Magdalena, primary, Oancea, Carmen-Nicoleta, additional, Neacșu, Sorinel Marius, additional, Musuc, Adina Magdalena, additional, Gheonea, Theodora Claudia, additional, Stanciu, Tiberius Iustinian, additional, Rogoveanu, Ion, additional, Hashemi, Fallah, additional, Stanciu, Gabriela, additional, Ioniță-Mîndrican, Corina-Bianca, additional, Belu, Ionela, additional, Măru, Nicoleta, additional, Olteanu, Gabriel, additional, Cîrțu, Alexandru-Tiberiu, additional, Stoicescu, Iuliana, additional, and Lupu, Carmen Elena, additional

Published
2023
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27. Characterization of Some Dermato-Cosmetic Preparations with Marine Lipids from Black Sea Wild Stingray

Author

Mititelu, Magdalena, primary, Licu, Monica, additional, Lupu, Carmen Elena, additional, Neacșu, Sorinel Marius, additional, Olteanu, Gabriel, additional, Gabriela, Stanciu, additional, Drăgănescu, Doina, additional, Oancea, Carmen-Nicoleta, additional, Busnatu, Ștefan Sebastian, additional, Hîncu, Lucian, additional, Ciocîlteu, Maria Viorica, additional, and Lupuleasa, Dumitru, additional

Published
2023
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28. Pharmacotechnical, Physico-Chemical, and Antioxidant Evaluation of Newly Developed Capsule Formulations

Author

Ozon, Emma Adriana, primary, Iuga, Izabela Dana Maria, additional, Mititelu, Magdalena, additional, Musuc, Adina Magdalena, additional, Manolescu, Bogdan Nicolae, additional, Petrescu, Simona, additional, Cusu, Jeanina Pandele, additional, Rusu, Adriana, additional, Surdu, Vasile-Adrian, additional, Oprea, Eliza, additional, Neacșu, Sorinel Marius, additional, Karampelas, Oana, additional, and Elian, Viviana, additional

Published
2023
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31. HPLC Analysis of Polyphenolic Compounds in Lysimachia nummularia L. and Comparative Determination of Antioxidant Capacity

Author

Suciu, Felicia, primary, Stoicescu, Iuliana, additional, Lupu, Elena Carmen, additional, Musuc, Adina Magdalena, additional, Popescu, Antoanela, additional, Mititelu, Magdalena, additional, Roșca, Adrian Cosmin, additional, Dumitrescu, Denisa-Elena, additional, Badea, Florin Ciprian, additional, Caraiane, Aureliana, additional, and Badea, Victoria, additional

Published
2023
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32. Synthesis, Characterization and Biocompatibility Evaluation of Novel Chitosan Lipid Micro-Systems for Modified Release of Diclofenac Sodium

Author

Pauna, Ana-Maria Raluca, primary, Mititelu Tartau, Liliana, additional, Bogdan, Maria, additional, Meca, Andreea-Daniela, additional, Popa, Gratiela Eliza, additional, Pelin, Ana Maria, additional, Drochioi, Cristian Ilie, additional, Pricop, Daniela Angelica, additional, and Pavel, Liliana Lacramioara, additional

Published
2023
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35. Zinc Chloride Enhances the Antioxidant Status, Improving the Functional and Structural Organic Disturbances in Streptozotocin-Induced Diabetes in Rats

Author

Anton, Irina Claudia, primary, Mititelu-Tartau, Liliana, additional, Popa, Eliza Gratiela, additional, Poroch, Mihaela, additional, Poroch, Vladimir, additional, Pelin, Ana-Maria, additional, Pavel, Liliana Lacramioara, additional, Drochioi, Ilie Cristian, additional, and Botnariu, Gina Eosefina, additional

Published
2022
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38. Honey and Other Beekeeping Products Intake among the Romanian Population and Their Therapeutic Use

Author

Ioniță-Mîndrican, Corina-Bianca, primary, Mititelu, Magdalena, additional, Musuc, Adina Magdalena, additional, Oprea, Eliza, additional, Ziani, Khaled, additional, Neacșu, Sorinel Marius, additional, Grigore, Nicoleta Diana, additional, Negrei, Carolina, additional, Dumitrescu, Denisa-Elena, additional, Mireșan, Horațiu, additional, Roncea, Florentina Nicoleta, additional, Ozon, Emma Adriana, additional, Măru, Nicoleta, additional, Drăgănescu, Doina, additional, and Ghica, Manuela, additional

Published
2022
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40. Multisystemic Inflammatory Syndrome in Children, A Disease with Too Many Faces: A Single-Center Experience

Author

Grama, Alina, primary, Căinap, Simona Sorana, additional, Mititelu, Alexandra, additional, Blag, Cristina, additional, Simu, Claudia, additional, Burac, Lucia, additional, Simionescu, Bianca, additional, Mărgescu, Camelia, additional, Sur, Genel, additional, Spârchez, Mihaela, additional, Bota, Mădălina, additional, Tănasă, Beatrice, additional, and Pop, Tudor Lucian, additional

Published
2022
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46. Automated versus Manual Mapping of Gravel Pit Lakes from South-Eastern Romania for Detailed Morphometry and Vegetation

Author

Bretcan, Petre, primary, Dunea, Daniel, additional, Vintescu, Gabriel, additional, Tanislav, Danut, additional, Zelenakova, Martina, additional, Predescu, Laurențiu, additional, Șerban, Gheorghe, additional, Borowiak, Dariusz, additional, Rus, Ioan, additional, Sabău, Daniel Andrei, additional, Mititelu-Ionuș, Oana, additional, Hueci, Maria, additional, Moreanu, Alexandru, additional, Samoila, Eduardt, additional, Nguyen, Huu Duy, additional, Frasin, Loredana Neagu, additional, Mirea, Ioana-Alexandra, additional, and Muntean, Răzvan-Cristian, additional

Published
2022
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48. State of the Art and Challenges in Epilepsy—A Narrative Review

Author

Aida Manole, Carmen Sirbu, Mihaela Mititelu, Octavian Vasiliu, Lorenzo Lorusso, Octavian Sirbu, and Florentina Ionita Radu

Subjects
Medicine (miscellaneous)
Abstract

Epilepsy is a common condition worldwide, with approximately 50 million people suffering from it. A single seizure does not mean epilepsy; almost 10% of the population can have a seizure during their lifetime. In particular, there are many other central nervous system disorders other than epilepsy in which seizures occur, either transiently or as a comorbid condition. The impact of seizures and epilepsy is, therefore, widespread and easily underestimated. It is estimated that about 70% of patients with epilepsy could be seizure-free if correctly diagnosed and treated. However, for patients with epilepsy, quality of life is influenced not only by seizure control but also by antiepileptic drug-adverse reactions, access to education, mood, employment, and transportation.

Published
2023
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49. The Impact of Medical Nutrition Intervention on the Management of Hyperphosphatemia in Hemodialysis Patients with Stage 5 Chronic Kidney Disease: A Case Series

Author

Elena Moroșan, Violeta Popovici, Viviana Elian, Adriana Maria Dărăban, Andreea Ioana Rusu, Monica Licu, Magdalena Mititelu, and Oana Karampelas

Subjects
Health, Toxicology and Mutagenesis, chronic kidney disease, hemodialysis, phosphatemia, medical nutrition therapy, phosphate binder drugs, compliance, Public Health, Environmental and Occupational Health
Abstract

The treatment and interdisciplinary management of patients with chronic kidney disease (CKD) continue to improve long-term outcomes. The medical nutrition intervention’s role is to establish a healthy diet plan for kidney protection, reach blood pressure and blood glucose goals, and prevent or delay health problems caused by kidney disease. Our study aims to report the effects of medical nutrition therapy—substituting foods rich in phosphorus-containing additives with ones low in phosphates content on phosphatemia and phosphate binders drug prescription in stage 5 CKD patients with hemodialysis. Thus, 18 adults with high phosphatemia levels (over 5.5 mg/dL) were monitored at a single center. Everyone received standard personalized diets to replace processed foods with phosphorus additives according to their comorbidities and treatment with prosphate binder drugs. Clinical laboratory data, including dialysis protocol, calcemia, and phosphatemia, were evaluated at the beginning of the study, after 30 and 60 days. A food survey was assessed at baseline and after 60 days. The results did not show significant differences between serum phosphate levels between the first and second measurements; thus, the phosphate binders’ initial doses did not change. After 2 months, phosphate levels decreased considerably (from 7.322 mg/dL to 5.368 mg/dL); therefore, phosphate binder doses were diminished. In conclusion, medical nutrition intervention in patients with hemodialysis significantly reduced serum phosphate concentrations after 60 days. Restricting the intake of processed foods containing phosphorus additives—in particularized diets adapted to each patient’s comorbidities—and receiving phosphate binders represented substantial steps to decrease phosphatemia levels. The best results were significantly associated with life expectancy; at the same time, they showed a negative correlation with the dialysis period and participants’ age.

Published
2023
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50. Towards the Construction of a Gold Standard Biomedical Corpus for the Romanian Language

Author

Maria Mitrofan, Verginica Barbu Mititelu, and Grigorina Mitrofan

Subjects
corpus, biomedical, Romanian, part-of-speech tags, named entities, Bibliography. Library science. Information resources
Abstract

Gold standard corpora (GSCs) are essential for the supervised training and evaluation of systems that perform natural language processing (NLP) tasks. Currently, most of the resources used in biomedical NLP tasks are mainly in English. Little effort has been reported for other languages including Romanian and, thus, access to such language resources is poor. In this paper, we present the construction of the first morphologically and terminologically annotated biomedical corpus of the Romanian language (MoNERo), meant to serve as a gold standard for biomedical part-of-speech (POS) tagging and biomedical named entity recognition (bioNER). It contains 14,012 tokens distributed in three medical subdomains: cardiology, diabetes and endocrinology, extracted from books, journals and blogposts. In order to automatically annotate the corpus with POS tags, we used a Romanian tag set which has 715 labels, while diseases, anatomy, procedures and chemicals and drugs labels were manually annotated for bioNER with a Cohen Kappa coefficient of 92.8% and revealed the occurrence of 1877 medical named entities. The automatic annotation of the corpus has been manually checked. The corpus is publicly available and can be used to facilitate the development of NLP algorithms for the Romanian language.

Published
2018
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