1. Focused Ultrasound in Neuroscience. State of the Art and Future Perspectives
- Author
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Gianluca Scalia, Bipin Chaurasia, Salvatore Marrone, Silvana Tumbiolo, Cesare Gagliardo, Francesca Graziano, Luigi Basile, Federico Midiri, Carlo Gulì, Giuseppe Roberto Giammalva, Rosario Maugeri, Kaan Yağmurlu, Federica Paolini, Ludovico La Grutta, Domenico Gerardo Iacopino, Maria Angela Pino, Rosa Maria Gerardi, Domenico Messina, Giuseppe Emmanuele Umana, Giammalva G.R., Gagliardo C., Marrone S., Paolini F., Gerardi R.M., Umana G.E., Yagmurlu K., Chaurasia B., Scalia G., Midiri F., Grutta L.L., Basile L., Guli C., Messina D., Pino M.A., Graziano F., Tumbiolo S., Iacopino D.G., and Maugeri R.
- Subjects
Opinion ,Computer science ,Neurodegenerative disease ,Focused ultrasound ,lcsh:RC321-571 ,03 medical and health sciences ,0302 clinical medicine ,neurodegenerative diseases ,lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry ,030304 developmental biology ,Blood-brain barrier ,tcMRgFUS ,LIFU ,0303 health sciences ,Epilepsy ,Settore MED/27 - Neurochirurgia ,General Neuroscience ,Settore MED/37 - Neuroradiologia ,Psychiatric disorder ,HIFU ,psychiatric disorders ,focused ultrasound ,Settore MED/26 - Neurologia ,Settore MED/36 - Diagnostica Per Immagini E Radioterapia ,Neuroscience ,neuro-oncology ,030217 neurology & neurosurgery - Abstract
Transcranial MR-guided Focused ultrasound (tcMRgFUS) is a surgical procedure that adopts focused ultrasounds beam towards a specific therapeutic target through the intact skull. The convergence of focused ultrasound beams onto the target produces tissue effects through released energy. Regarding neurosurgical applications, tcMRgFUS has been successfully adopted as a non-invasive procedure for ablative purposes such as thalamotomy, pallidotomy, and subthalamotomy for movement disorders. Several studies confirmed the effectiveness of tcMRgFUS in the treatment of several neurological conditions, ranging from motor disorders to psychiatric disorders. Moreover, using low-frequencies tcMRgFUS systems temporarily disrupts the blood–brain barrier, making this procedure suitable in neuro-oncology and neurodegenerative disease for controlled drug delivery. Nowadays, tcMRgFUS represents one of the most promising and fascinating technologies in neuroscience. Since it is an emerging technology, tcMRgFUS is still the subject of countless disparate studies, even if its effectiveness has been already proven in many experimental and therapeutic fields. Therefore, although many studies have been carried out, many others are still needed to increase the degree of knowledge of the innumerable potentials of tcMRgFUS and thus expand the future fields of application of this technology.
- Published
- 2021