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18 results on '"Midena, Giulia"'

2. Validation of an Automated Artificial Intelligence Algorithm for the Quantification of Major OCT Parameters in Diabetic Macular Edema

Author

Midena, Edoardo, primary, Toto, Lisa, additional, Frizziero, Luisa, additional, Covello, Giuseppe, additional, Torresin, Tommaso, additional, Midena, Giulia, additional, Danieli, Luca, additional, Pilotto, Elisabetta, additional, Figus, Michele, additional, Mariotti, Cesare, additional, and Lupidi, Marco, additional

Published
2023
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13. USH2A-Related Retinitis Pigmentosa: Staging of Disease Severity and Morpho-Functional Studies

Author

Falsini, Benedetto, primary, Placidi, Giorgio, additional, De Siena, Elisa, additional, Savastano, Maria Cristina, additional, Minnella, Angelo Maria, additional, Maceroni, Martina, additional, Midena, Giulia, additional, Ziccardi, Lucia, additional, Parisi, Vincenzo, additional, Bertelli, Matteo, additional, Maltese, Paolo Enrico, additional, Chiurazzi, Pietro, additional, and Rizzo, Stanislao, additional

Published
2021
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16. Orbital and Eyelid B-Cell Lymphoma: A Multicenter Retrospective Study

Author

Savino, Gustavo, primary, Midena, Giulia, additional, Blasi, Maria Antonietta, additional, Battendieri, Remo, additional, Grimaldi, Gabriela, additional, Maceroni, Martina, additional, Tranfa, Fausto, additional, Napolitano, Pasquale, additional, Lanni, Vittoria, additional, and Iuliano, Adriana, additional

Published
2020
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17. Aqueous Humor Cytokines in Idiopathic Epiretinal Membrane: Correlation with Disease Severity.

Author

Torresin T, Greggio A, Frisina R, Motta L, Gius I, Midena G, and Midena E

Abstract

Background: To analyze the concentration of aqueous humor (AH) cytokines in eyes with idiopathic epiretinal membrane (iERM) and to investigate their potential correlation with disease severity., Methods: Retrospective cross-sectional case-control institutional study. A total of 16 eyes of 16 iERM patients and 14 eyes of 14 age-matched healthy controls were enrolled. AH samples were analyzed for various biomarkers using a glass-chip protein array. Cytokines associated with inflammation, fibrosis, angiogenesis, and glial signal transduction were quantified., Results: Significant differences in cytokine concentration were observed between the iERM group and controls, with 19 cytokines elevated in the iERM group (among them IL-6, IL-8, PDGF-AB, PDGF-BB, TGFB-1, TGFB-2, TGFB-3, VEGF A, VEGF C, VEGF D, p < 0,05, 95% confidence interval). Correlation analysis revealed associations between cytokine levels and iERM severity. Notably, stages 2, 3, and 4 of iERM demonstrated increased levels of various biomarkers., Conclusions: This study provides insights into the complex molecular interactions underlying iERM pathogenesis, describing a correlation between neuroinflammation and iERM severity., Competing Interests: The authors declare no conflicts of interest.

Published
2024
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18. Outer Retinal and Choroidal Changes in Adolescents with Long-Lasting Type 1 Diabetes.

Author

Pilotto E, Cosmo E, Torresin T, Coppola M, Gutierrez De Rubalcava Doblas J, Midena G, Moretti C, and Midena E

Abstract

This study aimed to assess outer retinal layer (ORL), retinal pigment epithelium (RPE), choroid (Ch) and choriocapillaris (CC) modifications in adolescents with long-lasting (>10 years) type 1 diabetes (T1D) without (noDR) or with diabetic retinopathy (DR). ORL and RPE thickness were measured at optical coherence tomography (OCT) macular scans. Vascular parameters of Ch and CC were quantified after elaboration of macular OCT-angiography (OCTA) images. Insulin dose and auxological and metabolic parameters were correlated with OCT and OCTA findings in patients. ORL thickness was higher in DR eyes than in noDR and healthy controls (HC), and RPE thickness was higher in noDR and DR eyes than in HC, with statistical significance for some sectors in noDR versus HC. No OCTA parameters of CC and Ch differed among groups, and no significant correlation was observed with auxological and metabolic parameters. In conclusion, ORL and RPE were both increased in adolescents with long-lasting T1D. Such changes were not associated with insulin dose and glycemia control, nor to any choroid or choriocapillaris flow change clinically detectable at OCTA, and they could be potential imaging biomarkers of disease progression.

Published
2023
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