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Your search keyword '"Masciale, Valentina"' showing total 8 results
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8 results on '"Masciale, Valentina"'

1. Chasing the Role of miRNAs in RCC: From Free-Circulating to Extracellular-Vesicle-Derived Biomarkers

Author

Mastrolia, Ilenia, primary, Catani, Virginia, additional, Oltrecolli, Marco, additional, Pipitone, Stefania, additional, Vitale, Maria Giuseppa, additional, Masciale, Valentina, additional, Chiavelli, Chiara, additional, Bortolotti, Carlo Augusto, additional, Nasso, Cecilia, additional, Grisendi, Giulia, additional, Sabbatini, Roberto, additional, and Dominici, Massimo, additional

Published
2023
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2. Chasing Circulating Biomarkers in Renal Cell Carcinoma: the Case of Extracellular Vesicles and their miRNA Cargos

Author

Mastrolia, Ilenia, primary, Catani, Virginia, additional, Oltrecolli, Marco, additional, Pipitone, Stefania, additional, Vitale, Maria Giuseppa, additional, Masciale, Valentina, additional, Chiavelli, Chiara, additional, Bortolotti, Carlo Augusto, additional, Nasso, Cecilia, additional, Grisendi, Giulia, additional, Sabbatini, Roberto, additional, and Dominici, Massimo, additional

Published
2023
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5. Molecular Mechanisms and Cellular Contribution from Lung Fibrosis to Lung Cancer Development

Author

Samarelli, Anna Valeria, Masciale, Valentina, Aramini, Beatrice, Coló, Georgina Pamela, Tonelli, Roberto, Marchioni, Alessandro, Bruzzi, Giulia, Gozzi, Filippo, Andrisani, Dario, Castaniere, Ivana, Manicardi, Linda, Moretti, Antonio, Tabbì, Luca, Guaitoli, Giorgia, Cerri, Stefania, Dominici, Massimo, and Clini, Enrico

Subjects
Lung Neoplasms, cancer associated fibroblasts (CAFs), QH301-705.5, CAFs, Review, respiratory system, idiopathic pulmonary fibrosis, lung cancer, myofibroblast, mechanotrasduction, Mechanotransduction, Cellular, respiratory tract diseases, Transforming Growth Factor beta1, Chemistry, Animals, Humans, Biology (General), Myofibroblasts, QD1-999
Abstract

Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive, fibrosing interstitial lung disease (ILD) of unknown aetiology, with a median survival of 2-4 years from the time of diagnosis. Although IPF has unknown aetiology by definition, there have been identified several risks factors increasing the probability of the onset and progression of the disease in IPF patients such as cigarette smoking and environmental risk factors associated with domestic and occupational exposure. Among them, cigarette smoking together with concomitant emphysema might predispose IPF patients to lung cancer (LC), mostly to non-small cell lung cancer (NSCLC), increasing the risk of lung cancer development. To this purpose, IPF and LC share several cellular and molecular processes driving the progression of both pathologies such as fibroblast transition proliferation and activation, endoplasmic reticulum stress, oxidative stress, and many genetic and epigenetic markers that predispose IPF patients to LC development. Nintedanib, a tyrosine-kinase inhibitor, was firstly developed as an anticancer drug and then recognized as an anti-fibrotic agent based on the common target molecular pathway. In this review our aim is to describe the updated studies on common cellular and molecular mechanisms between IPF and lung cancer, knowledge of which might help to find novel therapeutic targets for this disease combination.

Published
2021

6. Deepening the Knowledge of ROS1 Rearrangements in Non-Small Cell Lung Cancer: Diagnosis, Treatment, Resistance and Concomitant Alterations

Author

Guaitoli, Giorgia, primary, Bertolini, Federica, additional, Bettelli, Stefania, additional, Manfredini, Samantha, additional, Maur, Michela, additional, Trudu, Lucia, additional, Aramini, Beatrice, additional, Masciale, Valentina, additional, Grisendi, Giulia, additional, Dominici, Massimo, additional, and Barbieri, Fausto, additional

Published
2021
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7. Circulating and Intracellular miRNAs as Prognostic and Predictive Factors in HER2-Positive Early Breast Cancer Treated with Neoadjuvant Chemotherapy: A Review of the Literature

Author

Isca, Chrystel, primary, Piacentini, Federico, additional, Mastrolia, Ilenia, additional, Masciale, Valentina, additional, Caggia, Federica, additional, Toss, Angela, additional, Piombino, Claudia, additional, Moscetti, Luca, additional, Barbolini, Monica, additional, Maur, Michela, additional, Dominici, Massimo, additional, and Omarini, Claudia, additional

Published
2021
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8. Expression of HOXB7 in the Lung of Patients with Idiopathic Pulmonary Fibrosis: A Proof-of-Concept Study.

Author

Samarelli AV, Tonelli R, Raineri G, Mastrolia I, Costantini M, Fabbiani L, Catani V, Petrachi T, Bruzzi G, Andrisani D, Gozzi F, Marchioni A, Masciale V, Aramini B, Ruggieri V, Grisendi G, Dominici M, Cerri S, and Clini E

Abstract

Background: The molecular pathways involved in the onset and progression of idiopathic pulmonary fibrosis (IPF) still need to be fully clarified as some are shared with lung cancer development. HOXB7, a member of the homeobox ( Hox ) gene family, has been found involved in various cancers., Methods: Immunohistochemical (IHC) analysis was run on lung tissue samples from surgical lung biopsy (SLB) of 19 patients with IPF, retrospectively selected from the IPF database of the University Hospital of Modena. HOXB7 expression was analyzed and compared with that of five patients with no evidence of pulmonary fibrosis as controls., Results: The semi-quantitative analysis of IHC showed that HOXB7 protein expression was higher in IPF patients compared to controls (difference between means = 6.2 ± 2.37, p = 0.0157). Further, HOXB7 expression was higher in IPF patients with a higher extent of fibrosis (50-75%)-measured with high-resolution computer tomography-compared to those with a lower extent (0-25%) (difference between means = 25.74 ± 6.72, p = 0.004)., Conclusions: The expression of HOXB7 is higher in the lung of IPF patients compared to controls, and was represented in different cellular compartments within the lung niche. Further investigations are needed to clarify its role in the pathogenesis and progression of IPF.

Published
2024
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