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Vibration mitigation of moving flexible structures is a key issue in many applications. Examples include antennas, solar arrays, radar reflectors, and manipulator arms, especially in the aerospace sector. These structures typically consist of inter-connected slender and flexible elements moved by external actuators to reach specific configurations and positions. The movements excite vibrations, which lead to the risk of structural and fatigue failures; once in position, residual vibrations can be further amplified by structure lightness, causing bad performance and malfunctioning of onboard sensors. This paper proposes an effective technique to minimise the vibration of moving flexible structures by calculating the control points of a time-parametrised B-spline representing the shape of the motion law. A testing case of a rotating cantilever beam is considered. Validation using multi-flexible-body simulation software has shown the method’s effectiveness in minimising residual vibrations.

3D printers, especially in the implementation of innovative extrusion processes which do not have a long history of development, are often built by adapting mechanical designs, drives and controls previously developed for generic machine tools. This is done through a process of choice and integration which is based principally on empirical criteria and taking into account separately the different aspects and parameters. Hereafter, we present an integrated mechatronic approach which has been adopted to design from the scratch a machine to implement the innovative metal injection moulding (MIM) technology. Its extrusion rate involves the adaptation of the generated trajectories and consequently requires “ad hoc” designs, drives and numerical controls (NC) to enable non standard acceleration (and hence torque) setpoint curves. Overall, the project resulted in an acceptable workspace volume (depending on the number of degrees of freedom of the platform) and allows one to combine the extruder flow rate, the given accuracy and the required working speed (1 m/s). The system is currently used as a test bench for exploring and optimizing the parameter space of a new MIM process.

This prospective study aimed to evaluate inflammatory status in cats affected by chronic kidney disease (CKD) at IRIS stages 2–4, using serum amyloid A (SAA) and the erythrocyte sedimentation rate (ESR) as inflammatory markers. Thirty-two cats with CKD and ten clinically healthy cats (i.e., control group) were enrolled. The recording of signalment data, complete physical examinations, and abdominal ultrasonography were performed for each animal. Additionally, ESR levels, complete blood count, clinical chemistry (including SAA determination), serum protein electrophoresis, and complete urinalysis were executed. This study’s results showed that mean ESR and SAA concentrations in cats with CKD were statistically higher compared to those of the control group (p = 0.0005 and p = 0.007, respectively). The SAA concentration was significantly increased at IRIS stages 2, 3, and 4 compared to the control group. Meanwhile, the ESR was significantly higher in cats at IRIS stages 3 and 4 (p = 0.0003 and p = 0.0007, respectively), but not at IRIS stage 2, compared to the control group. These results provide evidence that feline CKD is associated with a systemic inflammatory status. Moreover, the rise in ESR appears to be more linked to advanced stages of the disease and could, therefore, correlate with the uremic condition.

Canine idiopathic epilepsy is a common neurological disease characterized by the enduring predisposition of the cerebral cortex to generate seizures. An etiological explanation has not been fully identified in humans and dogs, and, among the presumed causes, several studies support the possible involvement of gut microbiota. In this review, the authors summarize the evidence of the reasonable role of gut microbiota in epilepsy through the so-called gut–brain axis. The authors provide an overview of recent clinical and preclinical studies in humans and dogs in which the modulation of intestinal permeability, the alteration of local immune response, and the alteration in production of essential metabolites and neurotransmitters associated with dysbiosis could be responsible for the pathogenesis of canine epilepsy. A systematic review of the literature, following the PRISMA guidelines, was performed in two databases (PubMed and Web of Science). Eleven studies were included and reviewed supporting the connection between gut microbiota and epilepsy via the gut–brain axis.