1. A Multi-Layer Perceptron Network for Perfusion Parameter Estimation in DCE-MRI Studies of the Healthy Kidney
- Author
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Arvid Lundervold, Eli Eikefjord, Michal Strzelecki, Marcin Kociolek, and Artur Klepaczko
- Subjects
Renal function ,Value (computer science) ,pharmacokinetic modeling ,lcsh:Technology ,030218 nuclear medicine & medical imaging ,Set (abstract data type) ,multi-layer perceptron ,lcsh:Chemistry ,03 medical and health sciences ,0302 clinical medicine ,General Materials Science ,skin and connective tissue diseases ,Instrumentation ,dynamic contrast-enhanced MRI ,lcsh:QH301-705.5 ,Mathematics ,Fluid Flow and Transfer Processes ,glomerular filtration rate ,Artificial neural network ,Estimation theory ,business.industry ,lcsh:T ,Process Chemistry and Technology ,General Engineering ,Pattern recognition ,Perceptron ,equipment and supplies ,lcsh:QC1-999 ,Computer Science Applications ,lcsh:Biology (General) ,lcsh:QD1-999 ,lcsh:TA1-2040 ,Multilayer perceptron ,Dynamic contrast-enhanced MRI ,Artificial intelligence ,business ,parameter estimation ,lcsh:Engineering (General). Civil engineering (General) ,human activities ,kidney perfusion ,030217 neurology & neurosurgery ,lcsh:Physics - Abstract
Background: Dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) is an imaging technique which helps in visualizing and quantifying perfusion&mdash, one of the most important indicators of an organ&rsquo, s state. This paper focuses on perfusion and filtration in the kidney, whose performance directly influences versatile functions of the body. In clinical practice, kidney function is assessed by measuring glomerular filtration rate (GFR). Estimating GFR based on DCE-MRI data requires the application of an organ-specific pharmacokinetic (PK) model. However, determination of the model parameters, and thus the characterization of GFR, is sensitive to determination of the arterial input function (AIF) and the initial choice of parameter values. Methods: This paper proposes a multi-layer perceptron network for PK model parameter determination, in order to overcome the limitations of the traditional model&rsquo, s optimization techniques based on non-linear least-squares curve-fitting. As a reference method, we applied the trust-region reflective algorithm to numerically optimize the model. The effectiveness of the proposed approach was tested for 20 data sets, collected for 10 healthy volunteers whose image-derived GFR scores were compared with ground-truth blood test values. Results: The achieved mean difference between the image-derived and ground-truth GFR values was 2.35 mL/min/1.73 m2, which is comparable to the result obtained for the reference estimation method (&minus, 5.80 mL/min/1.73 m2). Conclusions: Neural networks are a feasible alternative to the least-squares curve-fitting algorithm, ensuring agreement with ground-truth measurements at a comparable level. The advantages of using a neural network are twofold. Firstly, it can estimate a GFR value without the need to determine the AIF for each individual patient. Secondly, a reliable estimate can be obtained, without the need to manually set up either the initial parameter values or the constraints thereof.
- Published
- 2020