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Your search keyword '"Maarten L. Donswijk"' showing total 2 results
Start Over Author "Maarten L. Donswijk" Publisher mdpi ag
2 results on '"Maarten L. Donswijk"'

1. Higher Preoperative Maximum Standardised Uptake Values (SUVmax) Are Associated with Higher Biochemical Recurrence Rates after Robot-Assisted Radical Prostatectomy for [68Ga]Ga-PSMA-11 and [18F]DCFPyL Positron Emission Tomography/Computed Tomography

Author

Katelijne C. C. de Bie, Hans Veerman, Yves J. L. Bodar, Dennie Meijer, Pim J. van Leeuwen, Henk G. van der Poel, Maarten L. Donswijk, André N. Vis, and Daniela E. Oprea-Lager

Subjects
prostate cancer, standardised uptake value, biochemical recurrence, [68Ga]Ga-PSMA-11, [18F]DCFPyL, PET/CT, Medicine (General), R5-920
Abstract

This study aimed to investigate the association between the 68Ga- or 18F-radiolabeled prostate-specific membrane antigen (PSMA) tracer expression, represented by the maximum standardised uptake value (SUVmax) of the dominant intraprostatic lesion, and biochemical recurrence (BCR) in primary prostate cancer (PCa) patients prior to robot-assisted radical prostatectomy (RARP). This was a retrospective, multi-centre cohort study of 446 patients who underwent [68Ga]Ga-PSMA-11 (n = 238) or [18F]DCFPyL (n = 206) Positron Emission Tomography/Computed Tomography (PET/CT) imaging prior to RARP. SUVmax was measured in the dominant intraprostatic PCa lesions. [18F]DCFPyL patients were scanned 60 ([18F]DCFPyL-60; n = 106) or 120 ([18F]DCFPyL-120; n = 120) minutes post-injection of a radiotracer and were analysed separately. To normalise the data, SUVmax was log transformed for further analyses. During a median follow-up of 24 months, 141 (30.4%) patients experienced BCR. Log2SUVmax was a significant predictor for BCR (p < 0.001). In the multivariable analysis accounting for these preoperative variables: initial prostate-specific antigen (PSA), radiologic tumour stage (mT), the biopsy International Society of Urological Pathology grade group (bISUP) and the prostate imaging and reporting data system (PI-RADS), Log2SUVmax was found to be an independent predictor for BCR in [68Ga]Ga-PSMA-11 (HR 1.32, p = 0.04) and [18F]DCFPyL-120 PET/CT scans (HR 1.55, p = 0.04), but not in [18F]DCFPyL-60 ones (HR 0.92, p = 0.72). The PSMA expression of the dominant intraprostatic lesion proved to be an independent predictor for BCR in patients with primary PCa who underwent [68Ga]Ga-PSMA-11 or [18F]DCFPyL-120 PET/CT scans, but not in those who underwent [18F]DCFPyL-60 PET/CT scans.

Published
2023
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2. Elective Neck Dissection or Sentinel Lymph Node Biopsy in Early Stage Oral Cavity Cancer Patients: The Dutch Experience

Author

C. René Leemans, Remco de Bree, Koos Boeve, Daphne Lobeek, Stefan M. Willems, Max J. H. Witjes, Maarten L. Donswijk, Robert P. Takes, W. Martin C. Klop, Inne J den Toom, Elisabeth Bloemena, Bart de Keizer, CCA - Cancer Treatment and quality of life, AGEM - Digestive immunity, Pathology, Oral and Maxillofacial Surgery / Oral Pathology, Otolaryngology / Head & Neck Surgery, ​Basic and Translational Research and Imaging Methodology Development in Groningen (BRIDGE), Guided Treatment in Optimal Selected Cancer Patients (GUTS), Damage and Repair in Cancer Development and Cancer Treatment (DARE), and Maxillofacial Surgery (VUmc)

Subjects
INVOLVEMENT, Cancer Research, medicine.medical_specialty, medicine.medical_treatment, Sentinel lymph node, INVASION, lcsh:RC254-282, Article, 03 medical and health sciences, 0302 clinical medicine, All institutes and research themes of the Radboud University Medical Center, SDG 3 - Good Health and Well-being, Biopsy, MANAGEMENT, Medicine, HEAD, elective neck dissection, Stage (cooking), 030223 otorhinolaryngology, sentinel lymph node biopsy, Lymph node, TUMOR THICKNESS, medicine.diagnostic_test, business.industry, Cancer, Neck dissection, oral cancer, medicine.disease, lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens, medicine.anatomical_structure, METASTASES, Oncology, 030220 oncology & carcinogenesis, Cohort, DEPTH, lymphatics, Radiology, SQUAMOUS-CELL CARCINOMA, business, Nanomedicine Radboud Institute for Molecular Life Sciences [Radboudumc 19], Cohort study, Rare cancers Radboud Institute for Health Sciences [Radboudumc 9], lymph node metastases
Abstract

Background: Sentinel lymph node biopsy (SLNB) has been introduced as a diagnostic staging modality for detection of occult metastases in patients with early stage oral cancer. Comparisons regarding accuracy to the routinely used elective neck dissection (END) are lacking in literature. Methods: A retrospective, multicenter cohort study included 390 patients staged by END and 488 by SLNB. Results: The overall sensitivity (84% vs. 81%, p = 0.612) and negative predictive value (NPV) (93%, p = 1.000) were comparable between END and SLNB patients. The END cohort contained more pT2 tumours (51%) compared to the SLNB cohort (23%) (p &lt, 0.001). No differences were found for sensitivity and NPV between SLNB and END divided by pT stage. In floor-of-mouth (FOM) tumours, SLNB had a lower sensitivity (63% vs. 92%, p = 0.006) and NPV (90% vs. 97%, p = 0.057) compared to END. Higher disease-specific survival (DSS) rates were found for pT1 SLNB patients compared to pT1 END patients (96% vs. 90%, p = 0.048). Conclusion: In the absence of randomized clinical trials, this study provides the highest available evidence that, in oral cancer, SLNB is as accurate as END in detecting occult lymph node metastases, except for floor-of-mouth tumours.

Published
2020
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