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10 results on '"MERAVIGLIA, Serena"'

1. Immune-Inflammatory Response in Lifespan. What Role Does It Play in Extreme Longevity? A Sicilian Semi- and Supercentenarians Study

Author

Accardi, Giulia, primary, Calabrò, Anna, additional, Caldarella, Rosalia, additional, Caruso, Calogero, additional, Ciaccio, Marcello, additional, De Simone, Marta De, additional, Ligotti, Mattia Emanuela, additional, Meraviglia, Serena, additional, Zarcone, Rosa, additional, Candore*, Giuseppina, additional, and Aiello, Anna, additional

Published
2024
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2. The Phenotypic Characterization of the Oldest Italian Man from December 28, 2020, to September 23, 2021, A.T., Strengthens the Idea That the Immune System can Play a Key Role in the Attainment of Extreme Longevity

Author

Accardi, Giulia, primary, Aiello, Anna, additional, Aprile, Stefano, additional, Calabrò, Anna, additional, Caldarella, Rosalia, additional, Caruso, Calogero, additional, Ciaccio, Marcello, additional, Dieli, Francesco, additional, Ligotti, Mattia Emanuela, additional, Meraviglia, Serena, additional, and Candore, Giuseppina, additional

Published
2023
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4. The Phenotypic Characterization of the Oldest Italian Men from December 28, 2020 to September 23, 2021, Antonino Turturici, Suggests a Role for Immune System in the Attainment of Extreme Longevity

Author

Accardi, Giulia, primary, Aiello, Anna, additional, Aprile, Stefano, additional, Calabrò, Anna, additional, Caldarella, Rosalia, additional, Ciaccio, Marcello, additional, Caruso, Calogero, additional, Dieli, Francesco, additional, Ligotti, Mattia Emanuela, additional, Meraviglia, Serena, additional, and Candore, Giuseppina, additional

Published
2023
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5. Ferritin Metabolism Reflects Multiple Myeloma Microenvironment and Predicts Patient Outcome

Author

Plano, Federica, primary, Gigliotta, Emilia, additional, Corsale, Anna Maria, additional, Azgomi, Mojtaba Shekarkar, additional, Santonocito, Carlotta, additional, Ingrascì, Manuela, additional, Di Carlo, Laura, additional, Augello, Antonino Elia, additional, Speciale, Maria, additional, Vullo, Candida, additional, Rotolo, Cristina, additional, Camarda, Giulia Maria, additional, Caccamo, Nadia, additional, Meraviglia, Serena, additional, Dieli, Francesco, additional, Siragusa, Sergio, additional, and Botta, Cirino, additional

Published
2023
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6. Monoclonal Gammopathies and the Bone Marrow Microenvironment: From Bench to Bedside and Then Back Again

Author

Plano, Federica, primary, Corsale, Anna Maria, additional, Gigliotta, Emilia, additional, Camarda, Giulia, additional, Vullo, Candida, additional, Di Simone, Marta, additional, Shekarkar Azgomi, Mojtaba, additional, Speciale, Maria, additional, Carlisi, Melania, additional, Caccamo, Nadia, additional, Dieli, Francesco, additional, Meraviglia, Serena, additional, Siragusa, Sergio, additional, and Botta, Cirino, additional

Published
2023
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10. Monoclonal Gammopathies and the Bone Marrow Microenvironment: From Bench to Bedside and Then Back Again

Author

Federica Plano, Anna Maria Corsale, Emilia Gigliotta, Giulia Camarda, Candida Vullo, Marta Di Simone, Mojtaba Shekarkar Azgomi, Maria Speciale, Melania Carlisi, Nadia Caccamo, Francesco Dieli, Serena Meraviglia, Sergio Siragusa, Cirino Botta, Plano, Federica, Corsale, Anna Maria, Gigliotta, Emilia, Camarda, Giulia, Vullo, Candida, Di Simone, Marta, Shekarkar Azgomi, Mojtaba, Speciale, Maria, Carlisi, Melania, Caccamo, Nadia, Dieli, Francesco, Meraviglia, Serena, Siragusa, Sergio, and Botta, Cirino

Subjects
bone marrow microenvironment, multiple myeloma, tumor associated immune cells, smoldering myeloma, Hematology, monoclonal gammopathy of undetermined significance
Abstract

Multiple myeloma (MM) is an incurable hematologic malignancy characterized by a multistep evolutionary pathway, with an initial phase called monoclonal gammopathy of undetermined significance (MGUS), potentially evolving into the symptomatic disease, often preceded by an intermediate phase called “smoldering” MM (sMM). From a biological point of view, genomic alterations (translocations/deletions/mutations) are already present at the MGUS phase, thus rendering their role in disease evolution questionable. On the other hand, we currently know that changes in the bone marrow microenvironment (TME) could play a key role in MM evolution through a progressive shift towards a pro-inflammatory and immunosuppressive shape, which may drive cancer progression as well as clonal plasma cells migration, proliferation, survival, and drug resistance. Along this line, the major advancement in MM patients’ survival has been achieved by the introduction of microenvironment-oriented drugs (including immunomodulatory drugs and monoclonal antibodies). In this review, we summarized the role of the different components of the TME in MM evolution from MGUS as well as potential novel therapeutic targets/opportunities.

Published
2023
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