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Dairy heifers in New Zealand are typically naturally mated by Jersey bulls to produce low-value non-replacement offspring sold for slaughter a few days after birth. Producing a beef-sired calf from a dairy heifer will increase the value of these calves for beef production but may compromise the subsequent career of the animals, in terms of milk production, rebreeding success, health, or survival of the heifer. This study aimed to determine the impact of low birthweight Angus and Hereford bulls versus breed-average Jersey bulls on the reproduction and production traits of first-calving dairy heifers. The experiment included 304 heifer-calf pairs over 2 years. Calves sired by Angus and Hereford bulls were 3.5–4.4 kg and 3.7–6.8 kg heavier than Jersey-sired calves and had a 4.2% and 9.3% incidence of assistance at birth for normally presented calves over the 2 years, respectively. No normally presented Jersey-sired calves were assisted. There was no difference in body condition score, pre-calving live weight, milk production, pregnancy rate, inter-calving interval, re-calving day, and 21-day re-calving rate of heifers mated to the different breeds of bulls. The results indicate that the Angus and Hereford bulls with low birthweight and high direct calving ease estimated breeding values (EBV) can be used to produce calves of greater value than Jersey-sired calves without impacting dairy heifer production. However, a small increase in assistance at calving could be expected.

Beef-breed bulls are used in dairy herds to produce a calf of greater value for finishing than calves sired by dairy bulls. There is limited research about which beef-breed bulls are most appropriate, and whether any negative impact on cow performance in terms of milk production and rebreeding should be considered. The aim of this case study was to compare the body condition score, milk production, and rebreeding performance of mixed-aged dairy cows bred to a selection of Angus and Hereford beef-breed bulls. Body condition score, post-calving live weight, milk production, rebreeding performance, and survival of 952 mixed-aged dairy cows artificially bred to 65 Angus and Hereford bulls were compared. There was no effect of service sire on post-calving live weight, days in milk, milk production, or inter-calving intervals of mixed-aged cows. Service sire had an effect on the calving day due to differences in gestation length (p < 0.001), although this did not translate into an effect on days in milk. A longer gestation length negatively influenced pregnancy rates, and greater birth weight of the calf negatively influenced survival to rebreeding (p < 0.05), indicating the potential for an effect of service sire. Selection of beef-breed service sires for dairy cows should include emphasis on lighter calves and shorter gestation lengths. The general absence of the service sire effect on the parameters measured in this study indicated that any of the service sires used in this experiment would be appropriate for use over dairy cows.

Production of beef-cross-dairy calves from dairy cows increases the value of non-replacement calves born to the dairy herd. The use of beef-breed sires may impact on calf birth weight, gestation length and pre-weaning growth rate of calves, which in turn influences the profitability of the dairy farm. The aim of this case study was to compare the birth weight, gestation length, and pre-weaning growth of progeny born to mixed-aged dairy cows on a single farm which were artificially bred to a selection of Angus and Hereford bulls, typical of those used over dairy herds in New Zealand. The birth weight, gestation length and pre-weaning growth of 980 calves sired by 65 sires were compared. Mean progeny birth weight (range 33.3–41.4 kg), gestation length (range 276.1–288.6 days), age at weaning (range 70.3–88.3 days) and pre-weaning ADG (range 0.63–0.76 kg/d) differed among sires (p < 0.001). There was a negative genetic correlation (−0.31) and positive phenotypic correlation (0.36) between gestation length and birth weight. Age at weaning was negatively correlated with birth weight (genetic: −0.56, phenotypic: −0.57). Bulls used in this study, and other bulls with similar genetic merit for birth weight and gestation length would be suitable for mating mixed-aged dairy cows in New Zealand.

Chronic wounds and their treatment present a significant burden to patients and healthcare systems alike, with their management further complicated by bacterial infection. Historically, antibiotics have been deployed to prevent and treat infections, but the emergence of bacterial antimicrobial resistance and the frequent development of biofilms within the wound area necessitates the identification of novel treatment strategies for use within infected chronic wounds. Here, several non-antibiotic compounds, polyhexamethylene biguanide (PHMB), curcumin, retinol, polysorbate 40, ethanol, and D-α-tocopheryl polyethylene glycol succinate 1000 (TPGS) were screened for their antibacterial and antibiofilm capabilities. The minimum inhibitory concentration (MIC) and crystal violet (CV) biofilm clearance against two bacteria frequently associated with infected chronic wounds, Staphylococcus aureus and Pseudomonas aeruginosa, were determined. PHMB was observed to have highly effective antibacterial activity against both bacteria, but its ability to disperse biofilms at MIC levels was variable. Meanwhile, TPGS had limited inhibitory activity but demonstrated potent antibiofilm properties. The subsequent combination of these two compounds in a formulation resulted in a synergistic enhancement of their capability to kill both S. aureus and P. aeruginosa and disperse their biofilms. Collectively, this work highlights the utility of combinatory approaches to the treatment of infected chronic wounds where bacterial colonization and biofilm formation remains significant issues.

The rapid rise in the health burden associated with chronic wounds is of great concern to policymakers, academia, and industry. This could be attributed to the devastating implications of this condition, and specifically, chronic wounds which have been linked to invasive microbial infections affecting patients’ quality of life. Unfortunately, antibiotics are not always helpful due to their poor penetration of bacterial biofilms and the emergence of antimicrobial resistance. Hence, there is an urgent need to explore antibiotics-free compounds/formulations with proven or potential antimicrobial, anti-inflammatory, antioxidant, and wound healing efficacy. The mechanism of antibiotics-free compounds is thought to include the disruption of the bacteria cell structure, preventing cell division, membrane porins, motility, and the formation of a biofilm. Furthermore, some of these compounds foster tissue regeneration by modulating growth factor expression. In this review article, the focus is placed on a number of non-antibiotic compounds possessing some of the aforementioned pharmacological and physiological activities. Specific interest is given to Aloevera, curcumin, cinnamaldehyde, polyhexanide, retinoids, ascorbate, tocochromanols, and chitosan. These compounds (when alone or in formulation with other biologically active molecules) could be a dependable alternative in the management or prevention of chronic wounds.