Search

Both scientific and industrial communities have a growing interest in marine renewable energies. There is a wide variety of technologies in this domain, with different degrees of maturity. This study focuses on two models of a mast-free vertical axis Darrieus tidal turbine with the objective of characterizing the effect of vertical confinement, rotor configuration, and fluid–structure interactions on their performances in free-surface flows. The first model comprised four straight rigid blades maintained by circular flanges on both ends of the rotor and the second model is equipped with free-ended interchangeable blades attached to a single upper flange. Two configurations of the second model mounted with either rigid or flexible blades were used, first for comparison with the dual-flange turbine, then in order to address the effect of fluid–structure interactions on the turbine performances. While the single-flange models exhibit a significantly lower efficiency at all operating points, it is observed that the use of flexible blades tends to enhance turbine performances at low Reynolds numbers. The flow topology obtained from PIV measurement at selected operating points is discussed with respect to the performance of each turbine model in order to highlight the role of the dynamic stall and blade–vortex interactions.

64CuCl2 is an economic radiotracer for oncologic PET investigations. In the present study, we characterized the uptake of 64CuCl2 in vivo by µPET/CT in an allograft 4T1-related mouse model (BALB/c) of advanced breast cancer. 18F-FDG was used as a comparator. Twenty-two animals were imaged 7–9 days following 4T1-cell implantation inside mammary glands. Dynamic 64CuCl2 µPET/CT acquisition or iterative static images up to 8 h p.i. were performed. Animal biodistribution and tumor uptake were first evaluated in vivo by µPET analysis and then assessed on tissue specimens. Concerning 18F-FDG µPET, a static acquisition was performed at 15 min and 60 min p.i. Tumor 64CuCl2 accumulation increased from 5 min to 4 h p.i., reaching a maximum value of 5.0 ± 0.20 %ID/g. Liver, brain, and muscle 64CuCl2 accumulation was stable over time. The tumor-to-muscle ratio remained stable from 1 to 8 h p.i., ranging from 3.0 to 3.7. Ex vivo data were consistent with in vivo estimations. The 18F-FDG tumor accumulation was 8.82 ± 1.03 %ID/g, and the tumor-to-muscle ratio was 4.54 ± 1.11. 64CuCl2 PET/CT provides good characterization of the 4T1-related breast cancer model and allows for exploration of non-glycolytic cellular pathways potentially of interest for theragnostic strategies.

This paper studies the optimal contract offered by a risk-neutral principal to a risk-averse agent when the agent’s hidden ability and action both improve the probability of the project being successful. We show that if the agent is sufficiently prudent and able, the principal induces a higher probability of success than under moral hazard, despite the costly informational rent given up. Moreover, there is distortion at the top. Finally, the conditions to avoid pooling are difficult to satisfy because of the different kinds of incentives to be managed and the overall trade-off between rent extraction, insurance, and efficiency involved.