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2 results on '"Kodai Murayama"'

1. Image Monitoring of Pharmaceutical Blending Processes and the Determination of an End Point by Using a Portable Near-Infrared Imaging Device Based on a Polychromator-Type Near-Infrared Spectrometer with a High-speed and High-Resolution Photo Diode Array Detector

Author

Kodai Murayama, Daitaro Ishikawa, Takuma Genkawa, Hiroyuki Sugino, Makoto Komiyama, and Yukihiro Ozaki

Subjects
near-infrared imaging, powder blending, in-line monitoring, Organic chemistry, QD241-441
Abstract

In the present study we have developed a new version (ND-NIRs) of a polychromator-type near-infrared (NIR) spectrometer with a high-resolution photo diode array detector, which we built before (D-NIRs). The new version has four 5 W halogen lamps compared with the three lamps for the older version. The new version also has a condenser lens with a shorter focal point length. The increase in the number of the lamps and the shortening of the focal point of the condenser lens realize high signal-to-noise ratio and high-speed NIR imaging measurement. By using the ND-NIRs we carried out the in-line monitoring of pharmaceutical blending and determined an end point of the blending process. Moreover, to determinate a more accurate end point, a NIR image of the blending sample was acquired by means of a portable NIR imaging device based on ND-NIRs. The imaging result has demonstrated that the mixing time of 8 min is enough for homogeneous mixing. In this way the present study has demonstrated that ND-NIRs and the imaging system based on a ND-NIRs hold considerable promise for process analysis.

Published
2015
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2. Image Monitoring of Pharmaceutical Blending Processes and the Determination of an End Point by Using a Portable Near-Infrared Imaging Device Based on a Polychromator-Type Near-Infrared Spectrometer with a High-speed and High-Resolution Photo Diode Array Detector

Author

Hiroyuki Sugino, Makoto Komiyama, Yukihiro Ozaki, Takuma Genkawa, Daitaro Ishikawa, and Kodai Murayama

Subjects
Materials science, powder blending, Chemistry, Pharmaceutical, Analytical chemistry, Pharmaceutical Science, Signal-To-Noise Ratio, in-line monitoring, Article, Analytical Chemistry, law.invention, lcsh:QD241-441, Optics, Halogens, lcsh:Organic chemistry, law, Drug Discovery, Technology, Pharmaceutical, Physical and Theoretical Chemistry, Focal point, Spectroscopy, Near-Infrared, Spectrometer, business.industry, Organic Chemistry, Detector, Process (computing), Sample (graphics), Photodiode, Polychromator, near-infrared imaging, Halogen lamp, Chemistry (miscellaneous), Molecular Medicine, business
Abstract

In the present study we have developed a new version (ND-NIRs) of a polychromator-type near-infrared (NIR) spectrometer with a high-resolution photo diode array detector, which we built before (D-NIRs). The new version has four 5 W halogen lamps compared with the three lamps for the older version. The new version also has a condenser lens with a shorter focal point length. The increase in the number of the lamps and the shortening of the focal point of the condenser lens realize high signal-to-noise ratio and high-speed NIR imaging measurement. By using the ND-NIRs we carried out the in-line monitoring of pharmaceutical blending and determined an end point of the blending process. Moreover, to determinate a more accurate end point, a NIR image of the blending sample was acquired by means of a portable NIR imaging device based on ND-NIRs. The imaging result has demonstrated that the mixing time of 8 min is enough for homogeneous mixing. In this way the present study has demonstrated that ND-NIRs and the imaging system based on a ND-NIRs hold considerable promise for process analysis.

Published
2015

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